View source for Biology:Mir-939 microRNA precursor family

{{Infobox rfam
| Name = mir-939 
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| Symbol = mir-939
| AltSymbols = 
| Rfam =  RF00981
| miRBase =
| miRBase_family = MIPF0000490
| RNA_type = [[Biology:MicroRNA|microRNA]]
| Tax_domain = ''[[Biology:Eukaryote|Eukaryota]];''
| GO =
| SO =
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| EntrezGene = 
| HGNCid = 
| OMIM = 
| PDB = 
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}}

In molecular biology '''mir-939 microRNA''' is a short [[Biology:Non-coding RNA|RNA]] molecule. [[Biology:MicroRNA|MicroRNA]]s function to regulate the expression levels of other genes by several mechanisms.

==Human inducible Nitric Oxide Synthase==
miR-939 directly regulates and [[Biology:Translation|translationally]] blocks the gene expression of human inducible [[Biology:Nitric oxide synthase|nitric oxide synthase]] (hiNOS) by binding to its [[Biology:Three prime untranslated region|3'UTR]]. There is dual regulation of hiNOS gene expression, with [[Biology:Cytokine|cytokine]]s inducing hiNOS transcription whilst also increasing miR-939 levels.<ref name="pmid22451906">{{cite journal |vauthors=Guo Z, Shao L, Zheng L, Du Q, Li P, John B, etal | title=miRNA-939 regulates human inducible nitric oxide synthase posttranscriptional gene expression in human hepatocytes. | journal=Proc Natl Acad Sci U S A | year= 2012 | volume= 109 | issue= 15 | pages= 5826–31 | pmid=22451906 | doi=10.1073/pnas.1118118109 | pmc=3326458 | bibcode=2012PNAS..109.5826G | doi-access=free }}</ref> Two functional binding sites within the hiNOS 3'UTR are essential for miR-939-mediated translational blockade and miR-939 has been shown to decrease cytokine-induced hiNOS expression, despite hiNOS mRNA levels and stability remaining unaffected. It has further been found that endogenous miR-939 expression in the liver may be induced by cytokines.

== See also ==
* [[Biology:MicroRNA|MicroRNA]]

==References==
{{reflist}}

==Further reading==

# {{Cite journal 
| last1 = Semaan | first1 = N. 
| last2 = Frenzel | first2 = L. 
| last3 = Alsaleh | first3 = G. 
| last4 = Suffert | first4 = G. 
| last5 = Gottenberg | first5 = J. E. 
| last6 = Sibilia | first6 = J. 
| last7 = Pfeffer | first7 = S. 
| last8 = Wachsmann | first8 = D. 
| editor1-last = El Khoury 
| editor1-first = Joseph 
| doi = 10.1371/journal.pone.0019827 
| title = MiR-346 Controls Release of TNF-α Protein and Stability of Its mRNA in Rheumatoid Arthritis via Tristetraprolin Stabilization 
| journal = PLOS ONE 
| volume = 6 
| issue = 5 
| pages = e19827 
| year = 2011 
| pmid = 21611196 
| pmc =3096642 
| bibcode = 2011PLoSO...619827S 
| doi-access = free 
}}
# {{Cite journal 
| last1 = Nymark | first1 = P. 
| last2 = Guled | first2 = M. 
| last3 = Borze | first3 = I. 
| last4 = Faisal | first4 = A. 
| last5 = Lahti | first5 = L. 
| last6 = Salmenkivi | first6 = K. 
| last7 = Kettunen | first7 = E. 
| last8 = Anttila | first8 = S. 
| last9 = Knuutila | first9 = S. 
| doi = 10.1002/gcc.20880 
| title = Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos- and histology-related changes in lung cancer 
| journal = Genes, Chromosomes and Cancer 
| volume = 50 
| issue = 8 
| pages = 585–597 
| year = 2011 
| pmid = 21563230 
| pmc = 
| s2cid = 39556202 
| url = https://zenodo.org/record/1094997 
}}

==External links==
* {{Rfam|id=RF00981|name=mir-939 microRNA precursor family}}

{{MiRNA precursor families}}

[[Category:MicroRNA]]
[[Category:MicroRNA precursor families]]

{{Sourceattribution|Mir-939 microRNA precursor family}}