View source for Biology:Murid gammaherpesvirus 68

{{Short description|Virus isolate}}
{{Virusbox
| parent = Rhadinovirus
| species = Murid gammaherpesvirus 4
| virus = Murid gammaherpesvirus 68
}}

'''Murid gammaherpesvirus 68''' (MuHV-68) is an isolate of the virus species ''[[Biology:Murid gammaherpesvirus 4|Murid gammaherpesvirus 4]]'', a member of the genus ''[[Biology:Rhadinovirus|Rhadinovirus]]''.  It is a member of the subfamily ''[[Biology:Gammaherpesvirinae|Gammaherpesvirinae]]'' in the family of ''[[Biology:Herpesviridae|Herpesviridae]]''. MuHV-68 serves as a model for study of human gammaherpesviruses which cause significant human disease including B-cell lymphoma and [[Medicine:Kaposi's sarcoma|Kaposi's sarcoma]]. The WUMS [[Biology:Strain|strain]] of MuHV-68 was fully sequenced and annotated in 1997,<ref>
{{cite journal |
journal = Journal of Virology |
date= August 1997 |pages= 5894–904 | volume= 71 |issue= 8 |
title = Complete sequence and genomic analysis of murine gammaherpesvirus 68 |author1=Herbet W. Virgin IV |author2=Philip Latreille |author3=Pamela Wamsley |author4=Kymberlie Hallsworth |author5=Karen E. Weck |author6=Albert J. Dal Canto |author7=Samuel H. Speck  |
doi= 10.1128/JVI.71.8.5894-5904.1997 |name-list-style=amp |url= |pmid=9223479 |pmc=191845
}}
</ref> and the necessity of most of its genes in viral replication was characterized by random transposon [[Biology:Mutagenesis|mutagenesis]].<ref>
{{cite journal |
journal = Proceedings of the National Academy of Sciences of the United States of America |date=March 2005 |pages= 3805–10 | volume= 102 |issue= 10 | doi = 10.1073/pnas.0404521102 |
title = Identification of viral genes essential for replication of murine γ-herpesvirus 68 using signature-tagged mutagenesis |author1=Moon Jung Song |author2=Seungmin Hwang |author3=Wendy H. Wong |author4=Ting-Ting Wu |author5=Sangmi Lee |author6=Hsiang-I Liao |author7=Ren Sun  |name-list-style=amp |pmid=15738413 |pmc=553290
|bibcode=2005PNAS..102.3805S |doi-access=free }}
</ref>

== Surface proteins ==
[[Biology:Alphaherpesvirinae|Alpha]]-, [[Biology:Betaherpesvirinae|beta]]-, and [[Biology:Gammaherpesvirinae|gammaherpesviruses]] display a heterodimer composed of [[Chemistry:Glycoprotein|glycoprotein]] H (gH) and glycoprotein L (gL) on their [[Biology:Viral envelope|envelopes]].  This [[Biology:Receptor (biochemistry)|receptor]] is involved in the cell-to-cell transmission of the virus.  Glycoprotein H has two [[Biology:Protein structure|conformations]].  Glycoprotein L is a chaperone protein which assures that gH takes on the correct conformation. Murid gammaherpesvirus 68 lack gL, gH misfolds. When alpha- or betaherpesviruses lack gL, they are noninfectious. Murid gammaherpesvirus 68 lacks gL, it remains infectious but is less able to bind to fibroblasts and epithelial cells.<ref>{{cite journal |
journal = Journal of Virology |
date = January 2007 |pages= 280–291 | volume=81 |issue= 1 |
title = Glycoprotein L Disruption Reveals Two Functional Forms of the Murine Gammaherpesvirus 68 Glycoprotein H |author1=Laurent Gillet |author2=Janet S. May |author3=Susanna Colaco |author4=Philip G. Stevenson  |name-list-style=amp |url= |doi=10.1128/jvi.01616-06 |pmid=17050601 |pmc=1797276
}}</ref>

The [[Biology:Open reading frame|open reading frame]] M7 of the MuHV-68 [[Biology:Genome|genome]] encodes for the surface receptor glycoprotein 150 (gp150). It is [[Biology:Homology|homologous]] to the Epstein-Barr virus membrane [[Biology:Antigen|antigen]] gp350/220.<ref name = Macáková/>  MuHV-68 is more closely related to the Kaposi's Sarcoma-associated herpesvirus (KSHV) than it is to the Epstein-Barr virus.  Glycoprotein K8.1 is the KSHV homolog of MuHV-68 gp150.<ref name = Stewart>{{cite journal |
journal = Journal of Virology |
date=  October 2004 | pages= 10449–10459 |volume= 78 |issue= 19 |
title = In Vivo Function of a Gammaherpesvirus Virion Glycoprotein: Influence on B-Cell Infection and Mononucleosis |author1=James P. Stewart |author2=Ondine J. Silvia |author3=Isobel M. D. Atkin |author4=David J. Hughes |author5=Bahram Ebrahimi |author6=Heiko Adler  |name-list-style=amp |url= |doi=10.1128/jvi.78.19.10449-10459.2004 |pmid=15367611 |pmc=516434}}</ref>   MuHV-68 is a very close relative of MuHV-72.  The MuHV-68 M7 gene differs from the corresponding MuHV-72 gene by five point mutations which alter four codons.<ref name = Macáková>{{ cite journal |
journal = Virus Genes |date=Jan 2003 |volume=26|
title =  Murine gammaherpesvirus (MuHV) M7 gene encoding glycoprotein 150 (gp150): difference in the sequence between 72 and 68 strains |vauthors=Macáková K, Matis J, Rezuchová I, Kúdela O, Raslová H, Kúdelová M |
pmid = 12683351 |
issue = 1 |
pages = 89–95 |
doi = 10.1023/a:1022390407991|s2cid=34818785 }}</ref> Glycoprotein 150 allows MuHV-68 to bind to B-cells.<ref name = Stewart/>

== References ==
{{Reflist}}

{{Taxonbar|from=Q6938569}}

{{Herpesvirales}}

{{DEFAULTSORT:Murid Herpesvirus 68}}
[[Category:Gammaherpesvirinae]]
[[Category:Animal virology]]

{{Sourceattribution|Murid gammaherpesvirus 68}}