View source for Biology:Mycothiol-dependent formaldehyde dehydrogenase

{{infobox enzyme
| Name       = mycothiol-dependent formaldehyde dehydrogenase
| EC_number  = 1.1.1.306
| CAS_number =
| GO_code    = 0050607
| image      = 
| width      = 
| caption    =  
}}
In [[Biology:Enzymology|enzymology]], a '''mycothiol-dependent formaldehyde dehydrogenase''' ({{EC number|1.1.1.306}}) is an [[Biology:Enzyme|enzyme]] that [[Chemistry:Catalysis|catalyzes]] the [[Chemistry:Chemical reaction|chemical reaction]]

:formaldehyde + mycothiol + NAD<sup>+</sup> <math>\rightleftharpoons</math> S-formylmycothiol + NADH + 2 H<sup>+</sup>

The 3 [[Biology:Substrate (biochemistry)|substrates]] of this enzyme are [[Physics:Formaldehyde|formaldehyde]], [[Chemistry:Mycothiol|mycothiol]], and [[Chemistry:Nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], whereas its 3 [[Chemistry:Product|products]] are S-formylmycothiol, [[Chemistry:Nicotinamide adenine dinucleotide|NADH]], and [[Physics:Hydrogen ion|H<sup>+</sup>]].<ref>{{cite journal | vauthors = Misset-Smits M, van Ophem PW, Sakuda S, Duine JA | title = Mycothiol, 1-O-(2'-[N-acetyl-L-cysteinyl]amido-2'-deoxy-alpha-D-glucopyranosyl)-D- myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase | journal = FEBS Letters | volume = 409 | issue = 2 | pages = 221–2 | date = June 1997 | pmid = 9202149 | doi = 10.1016/S0014-5793(97)00510-3 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Norin A, Van Ophem PW, Piersma SR, Persson B, Duine JA, Jörnvall H | title = Mycothiol-dependent formaldehyde dehydrogenase, a prokaryotic medium-chain dehydrogenase/reductase, phylogenetically links different eukaroytic alcohol dehydrogenases--primary structure, conformational modelling and functional correlations | journal = European Journal of Biochemistry | volume = 248 | issue = 2 | pages = 282–9 | date = September 1997 | pmid = 9346279 | doi = 10.1111/j.1432-1033.1997.00282.x | doi-access = free }}</ref><ref>{{cite journal | vauthors = Vogt RN, Steenkamp DJ, Zheng R, Blanchard JS | title = The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase | journal = The Biochemical Journal | volume = 374 | issue = Pt 3 | pages = 657–66 | date = September 2003 | pmid = 12809551 | pmc = 1223637 | doi = 10.1042/BJ20030642 }}</ref><ref>{{cite journal | vauthors = Rawat M, Av-Gay Y | title = Mycothiol-dependent proteins in actinomycetes | journal = FEMS Microbiology Reviews | volume = 31 | issue = 3 | pages = 278–92 | date = April 2007 | pmid = 17286835 | doi = 10.1111/j.1574-6976.2006.00062.x | doi-access = free }}</ref> This enzyme [[Chemistry:Catalysis|catalyses]] the following [[Chemistry:Chemical reaction|chemical reaction]]

This enzyme belongs to the family of [[Biology:Oxidoreductase|oxidoreductase]]s, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor.  The [[Biology:List of enzymes|systematic name]] of this enzyme class is '''formaldehyde:NAD+ oxidoreductase (mycothiol-formylating)'''. This enzyme is also called '''NAD/factor-dependent formaldehyde dehydrogenase''' or '''S-(hydroxymethyl)mycothiol dehydrogenase'''.

==References==
{{reflist|1}}

{{Aldehyde/Oxo oxidoreductases}}
{{Enzymes}}

[[Category:EC 1.1.1]]
[[Category:NADH-dependent enzymes]]
[[Category:Enzymes of unknown structure]]



{{Sourceattribution|Mycothiol-dependent formaldehyde dehydrogenase}}