View source for Biology:N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase

{{Infobox enzyme
| Name       = N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
| EC_number  = 3.5.1.103
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase''' ({{EC number|3.5.1.103}}, ''MshB'') is an [[Biology:Enzyme|enzyme]] with [[Biology:List of enzymes|systematic name]] ''1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol acetylhydrolase''.<ref>{{cite journal | vauthors = Rawat M, Kovacevic S, Billman-Jacobe H, Av-Gay Y | title = Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis | journal = Microbiology | volume = 149 | issue = Pt 5 | pages = 1341–9 | date = May 2003 | pmid = 12724395 | doi = 10.1099/mic.0.26084-0 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Newton GL, Av-Gay Y, Fahey RC | title = N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis | journal = Journal of Bacteriology | volume = 182 | issue = 24 | pages = 6958–63 | date = December 2000 | pmid = 11092856 | pmc = 94821 | doi = 10.1128/jb.182.24.6958-6963.2000 }}</ref><ref>{{cite journal | vauthors = Maynes JT, Garen C, Cherney MM, Newton G, Arad D, Av-Gay Y, Fahey RC, James MN | title = The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold | journal = The Journal of Biological Chemistry | volume = 278 | issue = 47 | pages = 47166–70 | date = November 2003 | pmid = 12958317 | doi = 10.1074/jbc.m308914200 | doi-access = free }}</ref> This enzyme [[Chemistry:Catalysis|catalyses]] the following [[Chemistry:Chemical reaction|chemical reaction]]

: 1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H<sub>2</sub>O <math>\rightleftharpoons</math> 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + [[Chemistry:Acetate|acetate]]

This enzyme mediates the rate limiting step in the [[Chemistry:Mycothiol|mycothiol]] biosynthesis pathway.

== References ==
{{reflist}}

== External links ==
* {{MeshName|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside+deacetylase}}

{{Carbon-nitrogen non-peptide hydrolases}}
{{Enzymes}}

[[Category:EC 3.5.1]]

{{Sourceattribution|N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase}}