View source for Biology:Novel coronavirus (2019-nCoV)

{{Medical citations needed|date=January 2020}}
{{Virusbox
| image             = 
| image_alt         = 
| image_caption     = IVDC, China CDC: Wuhan coronavirus
| parent            = Incertae sedis/Betacoronavirus
| virus             = Novel coronavirus (2019-nCoV)
| subdivision_ranks = 
| subdivision_ref   = 
| subdivision       = 
| synonyms          = 
* Wuhan seafood market pneumonia virus
* Wuhan pneumonia
* Wuhan coronavirus
| synonyms_ref      = 
| range_map         = File:Wuhan China.png
| range_map_caption = Wuhan, China; primary location of the only recorded outbreak
}}
{{Infobox genome
| image       = <!-- Karyotype, for instance -->
| caption     = 
| type        = nucleotide
| taxId       = MN908947
| ploidy      = <!-- haploid, diploid or polypoloid -->
| chromosomes = <!-- number (unit is pairs) -->
| size        = 30473 bp
| year        = 2020
}}

'''Novel coronavirus''', denoted '''2019-nCoV''' by the [[Organization:World Health Organization|WHO]]<ref>{{Cite web|url=https://www.who.int/publications-detail/surveillance-case-definitions-for-human-infection-with-novel-coronavirus-(ncov)|title=Surveillance case definitions for human infection with novel coronavirus (nCoV)|website=www.who.int|language=en|access-date=2020-01-21}}</ref><ref>{{cite web|url=https://www.cdc.gov/coronavirus/novel-coronavirus-2019.html|title=Novel coronavirus (2019-nCoV), Wuhan, China|last=|first=|date=10 January 2020|website=|publisher=cdc.gov|url-status=live|archive-url=|archive-date=|accessdate=16 January 2020}}</ref> and also known as '''Wuhan coronavirus''', '''Wuhan seafood market pneumonia virus''' and '''Wuhan pneumonia''',<ref name="MN908947">{{cite journal |last1=Zhang |first1=Y.-Z. |display-authors=0 |title=Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome |url=https://www.ncbi.nlm.nih.gov/nuccore/MN908947 |website=GenBank |accessdate=13 January 2020 |location=Bethesda MD |language=en |date=12 January 2020}}</ref> is a [[Biology:Positive-sense single-stranded RNA virus|positive-sense, single-stranded RNA]] [[Biology:Coronavirus|coronavirus]] first reported in 2019. The virus was genomically sequenced after [[Medicine:Nucleic acid test|nucleic acid test]]ing on a positive patient sample in a patient with [[Medicine:Pneumonia|pneumonia]] during the 2019–2020 Wuhan pneumonia outbreak.<ref>{{cite web|url=http://www.chinacdc.cn/dfdt/201912/t20191226_209404.html|title=中国疾病预防控制中心|website=www.chinacdc.cn|access-date=9 January 2020}}</ref><ref name=":0">{{cite web|url=http://www.xinhuanet.com/english/2020-01/09/c_138690570.htm|title=New-type coronavirus causes pneumonia in Wuhan: expert – Xinhua {{!}} English.news.cn|website=www.xinhuanet.com|access-date=9 January 2020}}</ref><ref name=":1">{{cite web|url=https://platform.gisaid.org/epi3/start/CoV2020|title=CoV2020|last=|first=|date=|website=platform.gisaid.org|url-status=live|archive-url=|archive-date=|access-date=12 January 2020}}</ref>

On 20 January 2020, human-to-human transmission was confirmed in Guangdong province, {{wipe|China}}, according to [[Biography:Zhong Nanshan|Zhong Nanshan]], head of the health commission team investigating the outbreak.<ref>{{Cite news|url=https://www.cbc.ca/news/health/coronavirus-human-to-human-1.5433187|title=China confirms human-to-human transmission of new coronavirus|last=|first=|date=Jan 20, 2020|work=CBC News|access-date=2020-01-21|url-status=live}}</ref> No specific treatment for the new virus is currently available, but existing [[Biology:Antiviral drug|anti-virals]] could be [[Medicine:Drug repositioning|repurposed]].<ref>{{Cite news|url=https://www.reuters.com/article/us-china-health-pneumonia-who-idUSKBN1ZD16J|title=WHO says new China coronavirus could spread, warns hospitals worldwide|date=2020-01-14|work=Reuters|access-date=2020-01-21|language=en}}</ref>

The virus has spread to [[Place:Bangkok|Bangkok]], [[Place:Tokyo|Tokyo]], {{wipe|South Korea}}, [[Place:Beijing|Beijing]], [[Place:Shanghai|Shanghai]], Guangdong Province, Taiwan, and Washington State in the United States. There have been 6 fatalities and 317 known cases.<ref>{{cite web |title=Wuhan virus: China reports fourth death in pneumonia outbreak; 15 medical workers infected |url=https://www.straitstimes.com/asia/east-asia/china-says-fourth-person-dies-in-wuhan-pneumonia-outbreak |website=straitstimes |accessdate=20 January 2020}}</ref>

==Phylogenetics==
Sequences of Wuhan betacoronavirus show similarities to [[Biology:Betacoronavirus|betacoronavirus]]es found in [[Biology:Bat|bat]]s; however, the virus is genetically distinct from other [[Biology:Coronavirus|coronavirus]]es such as ''[[Biology:Severe acute respiratory syndrome-related coronavirus|Severe acute respiratory syndrome-related coronavirus]]'' (SARS) and ''[[Biology:Middle East respiratory syndrome-related coronavirus|Middle East respiratory syndrome-related coronavirus]]'' (MERS).<ref name=":1" /> Like SARS-CoV, it is a member of Beta-CoV lineage B.<ref>{{cite web |title=Phylogeny of SARS-like betacoronaviruses |url=https://nextstrain.org/groups/blab/sars-like-cov |website=nextstrain |accessdate=18 January 2020}}</ref>

Five genomes of the novel coronavirus have been isolated and reported including BetaCoV/Wuhan/IVDC-HB-01/2019, BetaCoV/Wuhan/IVDC-HB-04/2020, BetaCoV/Wuhan/IVDC-HB-05/2019, BetaCoV/Wuhan/WIV04/2019, and BetaCoV/Wuhan/IPBCAMS-WH-01/2019 from the [[Organization:Chinese Center for Disease Control and Prevention|China CDC]] National Institute for Viral Disease Control and Prevention, Institute of Pathogen Biology, and Wuhan Jinyintan Hospital.<ref name=":1" /><ref>{{cite web|url=http://virological.org/t/initial-genome-release-of-novel-coronavirus/319|title=Initial genome release of novel coronavirus|date=11 January 2020|website=Virological|language=en-US|access-date=12 January 2020}}</ref><ref>{{Cite journal|date=2020-01-17|title=Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome|url=http://www.ncbi.nlm.nih.gov/nuccore/MN908947.3|language=en-US}}</ref> Its [[Biology:RNA|RNA]] sequence is approximately 30 [[Biology:Base pair#Length measurements|kbp]] in length.<ref name=":1" />

==See also==
* [[Biology:2019–20 outbreak of novel coronavirus (2019-nCoV)|2019–20 outbreak of novel coronavirus (2019-nCoV)]]

Diseases caused by genetically similar viruses:

* [[Unsolved:Severe acute respiratory syndrome|Severe acute respiratory syndrome (SARS)]]
* [[Medicine:Middle East respiratory syndrome|Middle East respiratory syndrome (MERS)]]

==References==
{{Reflist|2}}

==External links==


{{Viral systemic diseases|state=collapsed}}
{{Taxonbar|from=Q82069695}}

[[Category:Betacoronaviruses]]

{{Sourceattribution|Novel coronavirus (2019-nCoV)|1}}