View source for Biology:PPT2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}
'''Lysosomal thioesterase PPT2''' (PPT-2), also known as '''S-thioesterase G14''', is an enzyme that in humans is encoded by the ''PPT2'' [[Biology:Gene|gene]].<ref name="entrez">{{cite web | title = Entrez Gene: palmitoyl-protein thioesterase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9374}}</ref><ref name="pmid9341199">{{cite journal | vauthors = Soyombo AA, Hofmann SL | title = Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity | journal = J. Biol. Chem. | volume = 272 | issue = 43 | pages = 27456–63 |date=October 1997 | pmid = 9341199 | doi = 10.1074/jbc.272.43.27456| doi-access = free }}</ref><ref name="pmid10051407">{{cite journal | vauthors = Soyombo AA, Yi W, Hofmann SL | title = Structure of the human palmitoyl-protein thioesterase-2 gene (PPT2) in the major histocompatibility complex on chromosome 6p21.3 | journal = Genomics | volume = 56 | issue = 2 | pages = 208–16 |date=March 1999 | pmid = 10051407 | doi = 10.1006/geno.1998.5703 }}</ref>

== Function ==
This gene encodes a member of the [[Biology:Palmitoyl protein thioesterase|palmitoyl protein thioesterase]] family. The encoded [[Biology:Glycosylation|glycosylated]] [[Biology:Lysosome|lysosomal]] protein has [[Chemistry:Palmitoyl-CoA|palmitoyl-CoA]] hydrolase activity in vitro, but does not hydrolyze palmitate from [[Chemistry:Cysteine|cysteine]] residues in proteins.<ref name="entrez"/>

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal   |vauthors=Gupta P, Soyombo AA, Atashband A|display-authors=0 |title=Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 24 |pages= 13566–71 |year= 2001 |pmid= 11717424  |pmc=61081 |doi= 10.1073/pnas.251485198 |bibcode=2001PNAS...9813566G |doi-access=free }}
*{{cite journal  |vauthors=Aguado B, Campbell RD |title=Characterization of a human MHC class III region gene product with S-thioesterase activity |journal=Biochem. J. |volume=341 ( Pt 3) |issue=  Pt 3|pages= 679–89 |year= 1999 |pmid= 10417332  |pmc=1220406 |doi=  10.1042/bj3410679}}
*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A|display-authors=0 |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2000 |pmid= 11256614  |pmc=1083732 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal   |vauthors=Hancock DB, Eijgelsheim M, Wilk JB|display-authors=0 |title=Meta-analyses of genome-wide association studies identify multiple novel loci associated with pulmonary function |journal=Nat. Genet. |volume=42 |issue= 1 |pages= 45–52 |year= 2010 |pmid= 20010835  |pmc=2832852 |doi= 10.1038/ng.500 }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R|display-authors=0 |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166  |pmc=311072 |doi= 10.1101/gr.GR1547R }}
*{{cite journal   |vauthors=Calero G, Gupta P, Nonato MC |display-authors=0 |title=The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2 |journal=J. Biol. Chem. |volume=278 |issue= 39 |pages= 37957–64 |year= 2003 |pmid= 12855696 |doi= 10.1074/jbc.M301225200 |doi-access=free }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK |display-authors=0 |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |bibcode=2003Natur.425..805M |doi-access=free }}
*{{cite journal   |vauthors=Barcellos LF, May SL, Ramsay PP |display-authors=0 |title=High-Density SNP Screening of the Major Histocompatibility Complex in Systemic Lupus Erythematosus Demonstrates Strong Evidence for Independent Susceptibility Regions |journal=PLOS Genet. |volume=5 |issue= 10 |pages= e1000696 |year= 2009 |pmid= 19851445  |pmc=2758598 |doi= 10.1371/journal.pgen.1000696  |editor1-last=Roopenian  |editor1-first=Derry C. |doi-access=free }}
*{{cite journal   |vauthors=McKinnon E, Morahan G, Nolan D |display-authors=0 |title=Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach |journal=Diabetes Obes Metab |volume=11 |issue=  Suppl 1|pages= 92–100 |year= 2009 |pmid= 19143821  |pmc=2755510 |doi= 10.1111/j.1463-1326.2008.01009.x }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I |display-authors=0 |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901  |pmc=1347501 |doi= 10.1093/nar/gkj139 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA |display-authors=0 |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334  |pmc=528928 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Xie T, Rowen L, Aguado B |display-authors=0 |title=Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621–36 |year= 2003 |pmid= 14656967  |pmc=403804 |doi= 10.1101/gr.1736803 }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2000 |pmid= 11076863  |pmc=310948 |doi=10.1101/gr.143000  }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E |display-authors=0 |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309  |pmc=403697 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH |display-authors=0 |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932  |pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W |display-authors=0 |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336  |pmc=528930 |doi= 10.1101/gr.2576704 }}
*{{cite journal  |vauthors=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2004 |pmid= 14759258  |pmc=395752 |doi= 10.1186/gb-2004-5-2-r8 |doi-access=free }}
{{refend}}

{{NLM content}}
{{Thioesterases}}
{{Enzymes}}

[[Category:EC 3.1.2]]



{{Sourceattribution|PPT2}}