View source for Biology:S100A8

{{Short description|Protein-coding gene in Homo sapiens}}
{{Infobox_gene}}

'''[[Biology:S100 protein|S100]] calcium-binding protein A8''' ('''S100A8''') is a [[Biology:Protein|protein]] that in humans is encoded by the ''S100A8'' [[Biology:Gene|gene]].<ref name="entrez"/> It is also known as [[Biology:Calgranulin|calgranulin]] A.

The proteins S100A8 and [[Biology:S100A9|S100A9]] form a heterodimer called [[Biology:Calprotectin|calprotectin]].

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis <ref name="entrez">{{cite web | title = Entrez Gene: S100A8 S100 calcium binding protein A8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6279}}</ref> and post COVID-19 condition.<ref>{{cite journal | vauthors = Ryan FJ, Hope CM, Masavuli MG, Lynn MA, Mekonnen ZA, Yeow AE, Garcia-Valtanen P, Al-Delfi Z, Gummow J, Ferguson C, O'Connor S, Reddi BA, Hissaria P, Shaw D, Kok-Lim C, Gleadle JM, Beard MR, Barry SC, Grubor-Bauk B, Lynn DJ | display-authors = 6 | title = Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection | journal = BMC Medicine | volume = 20 | issue = 1 | pages = 26 | date = January 2022 | pmid = 35027067 | pmc = 8758383 | doi = 10.1186/s12916-021-02228-6 | doi-access = free }}</ref>

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Schäfer BW, Heizmann CW | title = The S100 family of EF-hand calcium-binding proteins: functions and pathology | journal = Trends in Biochemical Sciences | volume = 21 | issue = 4 | pages = 134–140 | date = April 1996 | pmid = 8701470 | doi = 10.1016/S0968-0004(96)80167-8 }}
* {{cite journal | vauthors = Kerkhoff C, Klempt M, Sorg C | title = Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9) | journal = Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | volume = 1448 | issue = 2 | pages = 200–211 | date = December 1998 | pmid = 9920411 | doi = 10.1016/S0167-4889(98)00144-X | doi-access = free }}
* {{cite journal | vauthors = Nacken W, Roth J, Sorg C, Kerkhoff C | title = S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity | journal = Microscopy Research and Technique | volume = 60 | issue = 6 | pages = 569–580 | date = April 2003 | pmid = 12645005 | doi = 10.1002/jemt.10299 | s2cid = 10145841 }}
* {{cite journal | vauthors = Roth J, Vogl T, Sorg C, Sunderkötter C | title = Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules | journal = Trends in Immunology | volume = 24 | issue = 4 | pages = 155–158 | date = April 2003 | pmid = 12697438 | doi = 10.1016/S1471-4906(03)00062-0 }}
* {{cite journal | vauthors = Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J | title = Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes | journal = Electrophoresis | volume = 13 | issue = 12 | pages = 960–969 | date = December 1992 | pmid = 1286667 | doi = 10.1002/elps.11501301199 | s2cid = 41855774 }}
* {{cite journal | vauthors = Lemarchand P, Vaglio M, Mauël J, Markert M | title = Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation | journal = The Journal of Biological Chemistry | volume = 267 | issue = 27 | pages = 19379–19382 | date = September 1992 | pmid = 1326551 | doi = 10.1016/S0021-9258(18)41786-3 | doi-access = free }}
* {{cite journal | vauthors = Schäfer T, Sachse GE, Gassen HG | title = The calcium-binding protein MRP-8 is produced by human pulmonary tumor cells | journal = Biological Chemistry Hoppe-Seyler | volume = 372 | issue = 1 | pages = 1–4 | date = January 1991 | pmid = 2039599 | doi = 10.1515/bchm3.1991.372.1.1 }}
* {{cite journal | vauthors = Dorin JR, Emslie E, van Heyningen V | title = Related calcium-binding proteins map to the same subregion of chromosome 1q and to an extended region of synteny on mouse chromosome 3 | journal = Genomics | volume = 8 | issue = 3 | pages = 420–426 | date = November 1990 | pmid = 2149559 | doi = 10.1016/0888-7543(90)90027-R }}
* {{cite journal | vauthors = Wilkinson MM, Busuttil A, Hayward C, Brock DJ, Dorin JR, Van Heyningen V | title = Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues | journal = Journal of Cell Science | volume = 91 ( Pt 2) | issue = 2 | pages = 221–230 | date = October 1988 | pmid = 3267695 | doi = 10.1242/jcs.91.2.221 }}
* {{cite journal | vauthors = Odink K, Cerletti N, Brüggen J, Clerc RG, Tarcsay L, Zwadlo G, Gerhards G, Schlegel R, Sorg C | display-authors = 6 | title = Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis | journal = Nature | volume = 330 | issue = 6143 | pages = 80–82 | year = 1987 | pmid = 3313057 | doi = 10.1038/330080a0 | s2cid = 4366579 | bibcode = 1987Natur.330...80O }}
* {{cite journal | vauthors = Lagasse E, Clerc RG | title = Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation | journal = Molecular and Cellular Biology | volume = 8 | issue = 6 | pages = 2402–2410 | date = June 1988 | pmid = 3405210 | pmc = 363438 | doi = 10.1128/mcb.8.6.2402 }}
* {{cite journal | vauthors = Dorin JR, Novak M, Hill RE, Brock DJ, Secher DS, van Heyningen V | title = A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene | journal = Nature | volume = 326 | issue = 6113 | pages = 614–617 | year = 1987 | pmid = 3561500 | doi = 10.1038/326614a0 | s2cid = 4242084 | bibcode = 1987Natur.326..614D }}
* {{cite journal | vauthors = Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW | title = Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family | journal = Genomics | volume = 25 | issue = 3 | pages = 638–643 | date = February 1995 | pmid = 7759097 | doi = 10.1016/0888-7543(95)80005-7 }}
* {{cite journal | vauthors = Umekawa T, Kurita T | title = Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone | journal = Biochemistry and Molecular Biology International | volume = 34 | issue = 2 | pages = 309–313 | date = September 1994 | pmid = 7849642 }}
* {{cite journal | vauthors = Engelkamp D, Schäfer BW, Mattei MG, Erne P, Heizmann CW | title = Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 14 | pages = 6547–6551 | date = July 1993 | pmid = 8341667 | pmc = 46969 | doi = 10.1073/pnas.90.14.6547 | doi-access = free | bibcode = 1993PNAS...90.6547E }}
* {{cite journal | vauthors = Roth J, Burwinkel F, van den Bos C, Goebeler M, Vollmer E, Sorg C | title = MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner | journal = Blood | volume = 82 | issue = 6 | pages = 1875–1883 | date = September 1993 | pmid = 8400238 | doi = 10.1182/blood.V82.6.1875.1875 | doi-access = free }}
* {{cite journal | vauthors = Miyasaki KT, Bodeau AL, Murthy AR, Lehrer RI | title = In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena | journal = Journal of Dental Research | volume = 72 | issue = 2 | pages = 517–523 | date = February 1993 | pmid = 8423249 | doi = 10.1177/00220345930720020801 | s2cid = 8311930 }}
* {{cite journal | vauthors = Marti T, Erttmann KD, Gallin MY | title = Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin | journal = Biochemical and Biophysical Research Communications | volume = 221 | issue = 2 | pages = 454–458 | date = April 1996 | pmid = 8619876 | doi = 10.1006/bbrc.1996.0616 }}
{{refend}}
{{PDB Gallery|geneid=6279}}

[[Category:S100 proteins]]


{{Sourceattribution|S100A8}}