View source for Biology:SLC7A9

{{infobox protein
|Name=solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
|caption=
|image=
|width=
|HGNCid=11067
|Symbol=SLC7A9
|AltSymbols=CSNU3
|EntrezGene=11136
|OMIM=604144
|RefSeq=NM_014270
|UniProt=P82251
|PDB=
|ECnumber=
|Chromosome=19
|Arm=q
|Band=13.1
|LocusSupplementaryData=
}}
'''Solute carrier family 7 (cationic amino acid transporter, y+ system), member 9''' also known as '''SLC7A9''' is a [[Biology:Protein|protein]] which in humans is encoded by the ''SLC7A9'' [[Biology:Gene|gene]].<ref name="entrez">{{cite web | title = SLC7A9  | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11136 | accessdate = }}</ref>

== Function ==
This gene encodes a protein that belongs to a family of light subunits of [[Biology:Amino acid transporter|amino acid transporter]]s. This protein plays a role in the high-affinity and sodium-independent transport of [[Chemistry:Cystine|cystine]] and neutral and dibasic amino acids, and appears to function in the reabsorption of cystine in the kidney tubule.<ref name="entrez"/> The protein associates with the protein coded for by [[Biology:SLC3A1|SLC3A1]].<ref name="pmid10471498">{{cite journal | vauthors = Feliubadaló L, Font M, Purroy J, Rousaud F, Estivill X, Nunes V, Golomb E, Centola M, Aksentijevich I, Kreiss Y, Goldman B, Pras M, Kastner DL, Pras E, Gasparini P, Bisceglia L, Beccia E, Gallucci M, de Sanctis L, Ponzone A, Rizzoni GF, Zelante L, Bassi MT, George AL, Manzoni M, De Grandi A, Riboni M, Endsley JK, Ballabio A, Borsani G, Reig N, Fernández E, Estévez R, Pineda M, Torrents D, Camps M, Lloberas J, Zorzano A, Palacín M | title = Non-type I cystinuria caused by mutations in SLC7A9, encoding a subunit (bo,+AT) of rBAT | journal = Nat. Genet. | volume = 23 | issue = 1 | pages = 52–7 |date=September 1999 | pmid = 10471498 | doi = 10.1038/12652 | url = | issn = }}</ref>

== Clinical significance ==
Mutations in this gene cause non-type I [[Medicine:Cystinuria|cystinuria]], a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids.<ref name="entrez"/>

==See also==
* Heterodimeric amino acid transporter
* [[Biology:Solute carrier family|Solute carrier family]]

== References ==
{{Reflist}}

{{NLM content}}

{{Membrane transport proteins}}

{{DEFAULTSORT:Slc7a9}}
[[Category:Solute carrier family]]



{{Sourceattribution|SLC7A9|1}}