View source for Biology:Von Hippel–Lindau binding protein 1

{{infobox protein
|Name=von Hippel-Lindau binding protein 1
|caption=
|image=
|width=
|HGNCid=12662
|Symbol=VBP1
|AltSymbols=
|EntrezGene=7411
|OMIM=300133
|RefSeq=NM_003372
|UniProt=P61758
|PDB=
|ECnumber=
|Chromosome=X
|Arm=q
|Band=28
|LocusSupplementaryData=
}}

'''Von Hippel–Lindau binding protein 1''' ('''VBP1'''), also known as "[[Biology:Prefoldin|prefoldin]] 3", is a chaperone protein that binds to [[Biology:Von Hippel–Lindau tumor suppressor|von Hippel–Lindau protein]] and transports it from perinuclear granules to the [[Biology:Cell nucleus|nucleus]] or [[Biology:Cytoplasm|cytoplasm]] inside the [[Biology:Cell|cell]].<ref>{{cite journal | vauthors = Tsuchiya H, Iseda T, Hino O  | title = Identification of a novel protein (VBP-1) binding to the von Hippel–Lindau (VHL) tumor suppressor gene product | journal = Cancer Research | volume = 56 | year = 1996 | pages = 2881–5 | pmid = 8674032 | issue = 13}}</ref> It is also involved in transporting nascent polypeptides to cytosolic [[Biology:Chaperonin|chaperonin]]s for post-translational [[Biology:Protein folding|folding]].<ref name=GenAtlas>{{cite web | title = GenAtlas report: VBP1 | url = http://www.dsi.univ-paris5.fr/genatlas/fiche.php?symbol=VBP1 | date = 2003-01-17 | accessdate = 2007-07-17}}</ref>

VBP1 is a 197–[[Chemistry:Amino acid|amino acid]] heterohexamer comprising two prefoldin-α and four prefoldin-β subunits,<ref name=GenAtlas/> and is a member of the prefoldin-α subunit [[Biology:Protein family|family]].<ref name=NiceProt>{{cite web | title = NiceProt report: P61758 (Prefoldin 3, human) | url = http://www.expasy.org/cgi-bin/niceprot.pl?P61758 | date = 2007-07-10 | accessdate = 2007-07-17}}</ref> It is ubiquitously expressed in tissues, and is located in the cell in the nucleus and cytoplasm.<ref name=NiceProt/> The VBP1 gene is located at Xq28.<ref>{{cite journal | vauthors = Brinke A, Green PM, Giannelli F  | title = Characterization of the gene (VBP1) and transcript for the von Hippel–Lindau binding protein and isolation of the highly conserved murine homologue | journal = Genomics | volume = 45 | pages = 105–12 | year = 1997 | pmid = 9339366 | doi = 10.1006/geno.1997.4902 | issue = 1}}</ref> [[Biology:Homology|Homologues]] are known to exist between human VBP1 and proteins in mice, ''[[Biology:Drosophila melanogaster|Drosophila]]'' and ''[[Biology:Caenorhabditis elegans|C. elegans]]''.<ref name=GenAtlas/>

==See also==
*[[Biology:Von Hippel–Lindau tumor suppressor|Von Hippel–Lindau tumor suppressor]]
*[[Medicine:Von Hippel–Lindau disease|Von Hippel–Lindau disease]]
*Eugen von Hippel
*Arvid Lindau

==References==
<references/>

==External links==
* {{MeshName|von+Hippel-Lindau+binding+protein+1,+human}}

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{{DEFAULTSORT:Von Hippel-Lindau binding protein 1}}
[[Category:Proteins]]



{{Sourceattribution|Von Hippel–Lindau binding protein 1|1}}