View source for Chemistry:List of polysubstance combinations

{{Short description|none}}
{{distinguish|Lacing (drugs)#Commonly laced substances}}
[[File:Combo 2.png|thumb|upright=1.3|A drug combination chart designed for [[harm reduction]] by TripSit<ref>{{Cite web|url=https://combo.tripsit.me/|title=Drug Combinations|website=combo.tripsit.me}}</ref>]]

'''Polysubstance''' use or '''multisubstance''' use is the use of combinations of psychoactive substances with both legal and illegal substances. This page lists polysubstance combinations that are entheogenic, recreational, or [[Medicine:Indication#Label indications vs. off-label indications|off-label indicated]] use of pharmaceuticals. For example, the [[Finance:Over-the-counter|over-the-counter]] motion sickness [[Chemistry:Combination drug|combination drug]] [[Chemistry:Dimenhydrinate|dimenhydrinate]] (8-chlorotheophylline/[[Chemistry:Diphenhydramine|diphenhydramine]]) is occasionally used in higher doses as a [[Chemistry:Dimenhydrinate#Recreational use|deliriant]]. The prescription medicine [[Chemistry:Adderall|Adderall]] ([[Chemistry:Dextroamphetamine|dextroamphetamine]] sulfate/[[Chemistry:Amphetamine|amphetamine]] sulfate/dextroamphetamine saccharate/amphetamine aspartate monohydrate) is also frequently used recreationally. However, using non-prescribed drugs, using non-prescribed dose regimen, can cause [[Medicine:Polysubstance dependence|polysubstance dependence]], or [[Medicine:Combined drug intoxication|combined drug intoxication]] which may lead to deaths.

==Table==
To avoid an excessively long list, the table below only lists recreational drug combinations that are not patent medicine.

{{sort under}}
{| class="wikitable sortable sort-under"
|-
! Drug 1
! Drug 2
! Drug 3
! Drug 4
! Polysubstance slang,<ref>{{cite web |title=Erowid Drug Slang & Terminology Vault : A - B |url=https://erowid.org/psychoactives/slang/ |website=erowid.org}}</ref><ref name="Telegraph">{{cite web |last1=Copping |first1=Jasper|title=Drug slang: what police must learn A to B |url=https://www.telegraph.co.uk/news/uknews/law-and-order/6519175/Drug-slang-what-police-must-learn-A-to-B.html|date=8 November 2009}}</ref><ref name="f223">{{cite web | title=Slang Terms and Code Words: A Reference for Law Enforcement Personnel | website=GovInfo | url=https://www.govinfo.gov/app/details/GOVPUB-J24-PURL-gpo130575 | access-date=2024-07-06}}</ref><br/>or brand name
! Intoxication name
! Comment
|-
! ''Any'' dissociative
| ''Any'' dissociative
| 
|
| Void flip
| Void flipping
| 
|-
!''Any'' dissociative
|[[Chemistry:N,N-Dimethyltryptamine|DMT]]
|
|
|Dime bar, angel flip
|Dimension flipping, angel flipping
|
|-
! ''Any'' depressant
| ''Any'' [[Chemistry:Stimulant|stimulant]]
| 
|
| [[Chemistry:Speedball (drug)|Speedball]], powerball, over and under
| Powerballing, speedballing<ref name="Erowid">{{Cite web|url=https://erowid.org/psychoactives/slang/|title=Erowid Drug Slang & Terminology Vault : A - B|website=erowid.org}}</ref>
| 
|-
! ''Any'' [[Chemistry:Pharmaceutical|pharmaceutical]]
| ''Any'' [[Chemistry:Pharmaceutical|pharmaceutical]]
| 
|
| [[Medicine:Polypharmacy|Polypharmacy]]
| Polypharmacy is most commonly defined as the use of five or more medications daily by an individual.<ref name=":3">{{Cite journal |last1=Masnoon |first1=Nashwa |last2=Shakib |first2=Sepehr |last3=Kalisch-Ellett |first3=Lisa |last4=Caughey |first4=Gillian E. |date=October 2017 |title=What is polypharmacy? A systematic review of definitions |journal=BMC Geriatrics |volume=17 |issue=1 |pages=230 |doi=10.1186/s12877-017-0621-2 |issn=1471-2318 |pmc=5635569 |pmid=29017448 |doi-access=free }}</ref> However, the definition of polypharmacy is still debated and can vary from two to 11 concurrent medications.<ref name=":3" />
|-
! ''Any drug''
| [[Biology:Cannabis (drug)|Cannabis]]
| 
|
| Amp joint<ref name="narconon.org">{{Cite web|title=Slang Terms for Drug Combinations |url=https://www.narconon.org/drug-abuse/polydrug/nicknames.html |access-date=2021-12-08 |website=Narconon International |language=en-us}}</ref>
| 
| 
|-
! ''Any drug''
| [[Chemistry:Nicotine|Nicotine]]
| 
|
| Cooler<ref name="Erowid" />
| 
| 
|-
! ''Any'' [[Chemistry:Beta-Carboline|β-Carboline]]<br/>containing plant (e.g.<br/>''[[Biology:Banisteriopsis caapi|Banisteriopsis caapi]]''<br/>or ''[[Biology:Peganum harmala|Peganum harmala]]'')
| [[Chemistry:N,N-Dimethyltryptamine|DMT]]
| 
|
| [[Chemistry:Ayahuasca|Ayahuasca]], [[Biology:Changa (drug)|Changa]]
| 
| Ayahuasca is drunk. Changa is smoked or vaped.
|-
! ''Any antiretroviral drug''
| [[Chemistry:Black tar heroin|Black tar heroin]]
| 
|
| [[Chemistry:Whoonga|Whoonga]], Nyaope <ref>Grelotti DJ, Closson EF, Smit JA, Mabude Z, Matthews LT, Safren SA, Bangsberg DR, Mimiaga MJ. Whoonga: potential recreational use of HIV antiretroviral medication in South Africa. ''AIDS Behav''. 2014 Mar;18(3):511-8. {{doi|10.1007/s10461-013-0575-0}} {{PMID|23955659}}</ref>
| 
| Widespread use in South Africa. Whoonga is classically reputed to be a combination of heroin with antiretroviral drugs such as [[Chemistry:Ritonavir|ritonavir]] and/or [[Chemistry:Efavirenz|efavirenz]], often combined with additional drugs such as cannabis or hashish, methamphetamine and/or [[Chemistry:Methaqualone|methaqualone]] 
|-  
! '''Any [[Chemistry:Benzodiazepine|Benzodiazepine]]'''  
| [[Chemistry:Psilocybin|Psilocybin]] or psilocybin mushrooms
|
| Warp Trip
| Warping / Warp Tripping
|
| When taken recreationally, a combination of benzodiazepine and psilocybin may soothe some of the more extreme negative effects often experienced during the peak and comedown phases of a psychedelic trip. Although benzodiazepines do not counteract the hallucinogenic and euphoric sensations caused by [[Chemistry:Psilocybin|Psilocybin]] (commonly found in psilocybin mushrooms), they are sometimes administered by medical professionals to mitigate symptoms of a "bad trip." This practice helps to gradually relieve overactive sensory responses and induces relaxation in the individual, easing their mental state.<ref>{{Cite web 
|last1=Guss |first1=Jeffrey 
|last2=Krause |first2=Robert |last3=Sloshower |first3=Jordan
|title=Yale Manual for Psilocybin-Assisted Therapy of Depression 
|date=2020 
|url=https://osf.io/u6v9y/download 
|website=Open Science Framework (OSF) 
|publisher=Yale University 
|access-date=2024-03-15}}</ref>
|-
! ''Any [[Chemistry:Deliriant|deliriant]]'' or [[Chemistry:Diphenhydramine|diphen{{shy}}hydramine]]
| [[Chemistry:MDMA|MDMA]]
| 
|
| Nightmare flip
| Nightmare flipping
| 
|-
! [[Chemistry:2C-B|2C-B]] or the closely related 2C-x
| [[Chemistry:LSD|LSD]] or any of the [[Chemistry:Lysergamides|Lysergamides]]
| [[Chemistry:MDMA|MDMA]] or any Empathogen-entactogen
|
| Ali flip<ref name=":2">{{cite web |title=Ali Flip : Candy Flip & Nexus Flip melted |url=https://chemical-collective.com/blog/candy-flip-lsdmdma-nexus-flip-mdma2c-b/ |access-date=2024-03-29 |work=Chemical Collective|date=29 March 2024 }}</ref><ref name="The base of Ali flipping - Chemical-collective">{{cite web |last1=El Guennouni |first1=Ali |title='Ali flip' LSD , MDMA & 2C-B use and combination in Therapy |url=https://chemical-collective.com/blog/lusage-et-la-combinaison-en-therapie-du-lsd-2cb-et-mdma/ |access-date=1 May 2023 |website=chemical-collective.com|date=12 March 2023 }}</ref>
| Ali flipping<ref name=":2"/><ref name="The base of Ali flipping - Chemical-collective"/>
| This combination start as a classic Candyflip and end in a Nexus flip.
The LSD is taken first, followed by the MDMA 4 hours later and then 2C-B is taken 2 hours after the MDMA ( so 6 hours after the LSD ).

MDMA can be replaced by [[Chemistry:6-APB|6-APB]], [[Chemistry:5-APB|5-APB]], [[Chemistry:6-MAPB|6-MAPB]] or [[Chemistry:5-MAPB|5-MAPB]], in this case the Empathogen is taken 2 hours after the LSD, while 2C-B may be replaced by [[Chemistry:2C-C|2C-C]], [[Chemistry:2C-D|2C-D]] or [[Chemistry:2C-B-FLY|2C-B-FLY]].

This combination's goal is to prolong the empathogenic effects of MDMA and the psychedelic effects of LSD. The idea is to have be able to experience an enhanced "Candyflipping" with a smoother comedown. The whole experience is long-lasting and can be too intense as all of these molecules synergize and potentiate each other.
|-
! [[Chemistry:2C-B|2C-B]]
| [[Chemistry:MDMA|MDMA]]
| 
|
| Nexus flip<ref name=":2"/><ref name="The base of Ali flipping - Chemical-collective"/>
| Nexus flipping<ref name=":2"/><ref name="The base of Ali flipping - Chemical-collective"/>
| The MDMA is often taken first and the 2C-B after the end of the MDMA peak (h+2/h+2.½).<ref>{{Cite web |last=Weiss |first=Suzannah |date=2024-02-16 |title=Nexus Flipping: What Happens When You Combine MDMA and 2C-B |url=https://doubleblindmag.com/nexus-flipping/ |access-date=2024-07-10 |website=DoubleBlind Mag |language=en-US}}</ref>
The 2C-B is supposed to help the empathogenic effect of the MDMA last longer.
|-
![[Chemistry:2C-B|2C-B]]
|DXM
|
|
|Nexuswalk<ref>{{Cite web |title=DXM & 2C-B - Erowid Exp - 'Nexuswalk - A Beautiful Mix of DXM and 2C-B' |url=https://erowid.org/experiences/exp.php?ID=116808 |access-date=2023-04-18 |website=erowid.org}}</ref>
|Nexuswalk
|Nexus (slang for 2C-B) + Robowalk (slang for walking on DXM), similar to Nexusflipping
|-
![[Chemistry:2C-B|2C-B]]
|[[Chemistry:LSD|LSD]]
|
|
|Gnome flip
|
|
|-
! [[Chemistry:2C-E|2C-E]]
| [[Chemistry:LSD|LSD]]
| [[Chemistry:MDMA|MDMA]]
|
| Haychmaich flip<ref name="Erowid" />
| Haychmaich flipping
| 
|-
! [[Chemistry:2C-P|2C-P]]
| [[Chemistry:2C-E|2C-E]]
| 
|
| Meskini Trip
| Meskini Tripping
| 
|-
! [[Chemistry:2C-E|2C-E]]
| [[Chemistry:MDMA|MDMA]] or any Empathogen-entactogen
| [[Chemistry:2C-B|2C-B]] or the closely related 2C-x
|
| Elias flip<ref name="Erowid" />
| Elias flipping
| The Elias Flipping inspired by the Ali Flip with the use of 2C-E instead of LSD.
|-
![[Chemistry:2C-E|2C-E]]
![[Chemistry:LSD|LSD]] or closely related [[Chemistry:Lysergamides|Lysergamides]] 
![[Chemistry:MDMA|MDMA]] or any Empathogen
|[[Chemistry:2C-B|2C-B]] or closely related [[Chemistry:2C (psychedelics)|2C-x]]
|Alias Flip 
|Alias flipping
|The Alias flip is a very powerful mix between an Elias flip and an Ali flip. The idea is to take substances in this order to maximize the duration of 2C-E with the LSD taken one hour after 2C-E. 
|-
! [[Chemistry:Alcohol (drug)|Alcohol]]
| [[Chemistry:Benzodiazepine|Benzodiazepine]]
| 
|
| Time flip
| Time flipping
| 
|-
! [[Chemistry:Alcohol (drug)|Alcohol]]
| [[Biology:Caffeine|Caffeine]]
| 
|
| [[Medicine:Caffeinated alcoholic drink|Caffeinated alcoholic drink]]
| 
| 
|-
! [[Chemistry:Alcohol (drug)|Alcohol]]
| [[Biology:Cannabis (drug)|Cannabis]]
| 
|
| Tincture of cannabis. Herb and Al. Judgement Day
| Cross fading, twisting, getting twisted<ref>{{cite journal |last1=Lankenau |first1=Stephen |last2=Clatts |first2=Michael |last3=Welle |first3=Dorinda |last4=Goldsamt |first4=Lloyd |last5=Gwadz |first5=Marya |title=Street careers: homelessness, drug use, and sex work among young men who have sex with men (YMSM) |journal=International Journal of Drug Policy |date=January 2005 |volume=16 |issue=1 |pages=10–18 |doi=10.1016/j.drugpo.2004.07.006}}</ref>
| Called Judgement Day in Ghana when cannabis is added to the drink
|-
! [[Chemistry:Alcohol (drug)|Alcohol]]
| [[Biology:Cocaine|Cocaine]]
| 
|
| Snow-cone
| Snow-coning
| Ethanol is metabolized into [[Chemistry:Cocaethylene|cocaethylene]]<ref>{{Cite journal |last1=Pergolizzi |first1=Joseph |last2=Breve |first2=Frank |last3=Magnusson |first3=Peter |last4=LeQuang |first4=Jo Ann K. |last5=Varrassi |first5=Giustino |date=2022-02-22 |title=Cocaethylene: When Cocaine and Alcohol Are Taken Together |journal=Cureus |language=en |volume=14 |issue=2 |pages=e22498 |doi=10.7759/cureus.22498 |doi-access=free |pmid=35345678 |pmc=8956485 |issn=2168-8184}}</ref>
|-
! [[Chemistry:Alcohol (drug)|Alcohol]]
| [[Chemistry:MDMA|MDMA]]
| 
|
| Tipsy flip
| Tipsy flipping
| It may be dangerous
|-
! [[Chemistry:Alcohol (drug)|Alcohol]]
| [[Chemistry:Nicotine|Nicotine]]
| 
|
| Nicotini
| 
| A nicotini is any alcoholic drink which includes nicotine as an ingredient. [[Medicine:Nicotine replacement therapy|Nicotine replacement therapy]] products such as mouth spray may be used.
|-
! [[Chemistry:Amphetamine|Amphetamine]]
| Barbiturates
|
|
| Inbetweens<ref name=":0">{{cite journal |last1=Keup |first1=Wolfram |title=The Vocabulary of the Drug User and Alcoholic: A Glossary |journal=The International Journal of the Addictions |date=June 1971 |volume=6 |issue=2 |page=348 |doi=10.3109/10826087109057793 |pmid=4950517 |url=https://pubmed.ncbi.nlm.nih.gov/4950517/ |access-date=7 October 2021}}</ref> Bam
|
|
|-
! [[Chemistry:Amphetamine|Amphetamine]]
| [[Biology:Cannabis (drug)|Cannabis]]
| [[Chemistry:LSD|LSD]]
|
|
|
|-
! [[Chemistry:Amphetamine|Amphetamine]]
| [[Biology:Cocaine|Cocaine]]
|
|
| Snow seals
|
|
|-
! [[Chemistry:Amphetamine|Amphetamine]]
| [[Chemistry:Heroin|Heroin]]
|
|
| Bombido<ref name=":0" />
|
|
|-
! [[Chemistry:Amphetamine|Amphetamine]]
| Xanax
|
|
| Orange Dream Blossom
| Cloud Rush
| The combination is crushed together and insufflated 
|-
! [[Biology:Atropa belladonna|Belladonna]]
| [[Chemistry:Hashish|Hashish]]
|
|
| Alamout black hash<ref name="Erowid" />
|
| Mixed
|-
! [[Biology:Caffeine|Caffeine]]
| [[Biology:Cannabis (drug)|Cannabis]]
|
|
| Hippie-[[Chemistry:Speedball (drug)|speedball]]<ref>{{Cite web |last=Crone |first=Madeline |date=2021-10-07 |title=Premiere: Singer-Songwriter Ben Chapman Defines a "Hippie Speedball" with a New Acoustic Video |url=https://americansongwriter.com/premiere-singer-songwriter-ben-chapman-defines-a-hippie-speedball-with-a-new-acoustic-video/ |access-date=2024-07-27 |website=American Songwriter |language=en-US}}</ref><ref>{{Cite web |last=Rizzo |first=Melanie |date=2022-03-21 |title=Coffee Alternatives: A Modern Spin on the Hippie Speedball |url=https://www.thebluntness.com/posts/a-modern-spin-on-the-hippie-speedball |access-date=2024-07-27 |website=TheBluntness |language=en-US}}</ref>
| Hippie-speedballing
|
|-
! [[Biology:Caffeine|Caffeine]]
| [[Chemistry:Diphenhydramine|Diphen{{shy}}hydramine]]
|
|
| Sleep walk
| Sleepwalking
|
|-
! [[Biology:Caffeine|Caffeine]]
| [[Chemistry:Methamphetamine|Meth{{shy}}amphetamine]]
|
|
| Ya ba, biker's coffee, kamikaze
|
|
|-
! Cacao bean
| Magic mushroom
|
|
|
|
| [[Chemistry:Aztec use of entheogens|Aztec use of entheogens]]. Conventional defatted cocoa solids dissolved in fat may be used instead of whole beans.
|-
! [[Chemistry:Cannabidiol|CBD]]
| [[Biology:Tetrahydrocannabinol|THC]]
|
|
|
|
| Low to moderate doses of CBD might reduce some of the paranoia, anxiety,<ref>{{Cite journal|vauthors=Gibson LP, Karoly HC, Ellingson JM, Klawitter J, Sempio C, Squeri JE, Bryan AD, Bidwell LC, Hutchison KE |date=2022 |title=Effects of cannabidiol in cannabis flower: Implications for harm reduction|journal=Addiction Biology |volume=27 |issue=1 |pages=e13092 |language=en |doi=10.1111/adb.13092 |pmid=34467598 |pmc=9357513 |s2cid=237372495}}</ref> and reduction of hippocampal volumes that the current high potency THC marijuana (in the last decades, THC content increased and CBD content decreased) can cause, if the CBD substitutes a part of the THC dose.<ref>{{Cite journal |last=Stuyt |first=Elizabeth |date=2018 |title=The Problem with the Current High Potency THC Marijuana from the Perspective of an Addiction Psychiatrist |journal=Missouri Medicine |volume=115 |issue=6 |pages=482–486 |issn=0026-6620 |pmc=6312155 |pmid=30643324}}</ref><ref>{{Cite journal |last1=ElSohly |first1=Mahmoud A. |last2=Mehmedic |first2=Zlatko |last3=Foster |first3=Susan |last4=Gon |first4=Chandrani |last5=Chandra |first5=Suman |last6=Church |first6=James C. |date=2016-04-01 |title=Changes in Cannabis Potency over the Last Two Decades (1995-2014) - Analysis of Current Data in the United States |journal=Biological Psychiatry |volume=79 |issue=7 |pages=613–619 |doi=10.1016/j.biopsych.2016.01.004 |issn=0006-3223 |pmc=4987131 |pmid=26903403}}</ref><ref>{{Cite journal |last1=Zamarripa |first1=C. Austin |last2=Spindle |first2=Tory R. |last3=Surujunarain |first3=Renuka |last4=Weerts |first4=Elise M. |last5=Bansal |first5=Sumit |last6=Unadkat |first6=Jashvant D. |last7=Paine |first7=Mary F. |last8=Vandrey |first8=Ryan |date=2023-02-01 |title=Assessment of Orally Administered Δ9-Tetrahydrocannabinol When Coadministered With Cannabidiol on Δ9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial |journal=JAMA Network Open |volume=6 |issue=2 |pages=e2254752 |doi=10.1001/jamanetworkopen.2022.54752 |issn=2574-3805 |pmc=9926328 |pmid=36780161}}</ref> Low doses of [[Biology:Mesembryanthemum tortuosum|Kanna]] might also help counteract the anxiety.<ref>{{Cite web |last=Sumpter |first=Luke |date=2022-12-29 |title=Combining Kanna with Weed or CBD: Should You Do It? |url=https://www.zamnesia.com/blog-combining-kanna-weed-cbd-n1980 |access-date=2023-02-05 |website=www.zamnesia.com |language=en}}</ref><ref>{{Cite journal |last1=Manganyi |first1=Madira Coutlyne |last2=Bezuidenhout |first2=Cornelius Carlos |last3=Regnier |first3=Thierry |last4=Ateba |first4=Collins Njie |date=2021-04-28 |title=A Chewable Cure "Kanna": Biological and Pharmaceutical Properties of Sceletium tortuosum |journal=Molecules (Basel, Switzerland) |volume=26 |issue=9 |pages=2557 |doi=10.3390/molecules26092557 |issn=1420-3049 |pmc=8124331 |pmid=33924742|doi-access=free }}</ref>
|-
! [[Biology:Cannabis (drug)|Cannabis]]
| Cocoa solids
|
|
| Cannabis-infused brownie
|
| Cannabis edible
|-
! [[Biology:Cannabis (drug)|Cannabis]]
| [[Engineering:Crack cocaine|Crack cocaine]]
|
|
| Crack weed (less known: Buddha, caviar, champagne, chronic, cocktail, dirty joint, fry daddy, gimmie, gremmies, juice joint, lace, oolies, p dog, primo, thirty eight, torpedo, turbo, wollie, yeola)<ref name="a">{{citation | author=Tom Dalzell | title=The Routledge Dictionary of Modern American Slang and Unconventional English | publisher=Routledge | year=2009 | isbn=978-0-415-37182-7}}</ref>
| Cocoa puffs, splitting
|
|-
! [[Biology:Cannabis (drug)|Cannabis]]
| [[Engineering:Crack cocaine|Crack cocaine]]
| [[Chemistry:Heroin|Heroin]]
|
| Major Pronin, El Diablo
|
|
|-
! [[Biology:Cannabis (drug)|Cannabis]]
| [[Engineering:Crack cocaine|Crack cocaine]]
| [[Chemistry:Phencyclidine|PCP]]
|
| Jim Jones
|
|
|-
! [[Biology:Cannabis (drug)|Cannabis]]
| Damiana
|
|
|
|
| Damiana and other herbs can be used as a tobacco alternative for rolling joints.<ref>{{Cite web |last=Ewe |first=Koh |date=2021-04-19 |title=TikTokers Are Smoking Flowers As Weed Alternatives |url=https://www.vice.com/en/article/4avyx9/tiktok-smoking-flowers-weed-alternative-herbal-cigarettes |access-date=2021-12-24|website=www.vice.com|language=en}}</ref>
|-
! [[Biology:Cannabis (drug)|Cannabis]]
| DXM
| [[Chemistry:Nicotine|Nicotine]]
|
| Candy blunt
|
|
|-
! [[Biology:Cannabis (drug)|Cannabis]]
| [[Chemistry:Heroin|Heroin]] or [[Biology:Opium|opium]]
|
|
| A-bomb, Atom bomb, stuff<ref name="Erowid" />
|
|
|-
! [[Biology:Cannabis (drug)|Cannabis]]
| [[Chemistry:MDMA|MDMA]]
|
|
| Stoner flip
| Stoner flipping
|
|-
! [[Biology:Cannabis (drug)|Cannabis]]
| [[Chemistry:Ketamine|Ketamine]]
|
|
| Stoner Kitty
|
| 
|-
! [[Biology:Cannabis (drug)|Cannabis]]
| [[Chemistry:Ketamine|Ketamine]]
| [[Biology:Cocaine|Cocaine]]
|
| Simmered
| Getting Simmered 
| 
|-
! [[Biology:Cannabis (drug)|Cannabis]]
| [[Chemistry:Nicotine|Nicotine]]
|
|
| Blunt, joint, spliff, Jonko
|
| A rolled cannabis cigarette usually made with rolling paper. A blunt is a cigar hollowed out and filled with cannabis. It is rolled with the tobacco-leaf "wrapper" from an inexpensive cigar. Blunts take their name from Phillies Blunt brand cigars.
|-
! [[Biology:Cannabis (drug)|Cannabis]]
| [[Biology:Opium|Opium]]
|
|
| Demetra
|
|
|-
! [[Biology:Cannabis (drug)|Cannabis]]
| [[Chemistry:Phencyclidine|PCP]]
|
|
| Wet (less known: Bionic, clickums, donk, illies, leak, love leaf, lovelies, parsley, supergrass, superweed, wet, zoom) 
| Illing
| Wet is cannabis dipped in PCP <ref>{{cite journal |last1=Holland |first1=Julie A. |last2=Nelson |first2=Lewis |last3=Ravikumar |first3=P. R. |last4=Elwood |first4=William N. |title=Embalming Fluid-Soaked Marijuana: New High or New Guise for PCP? |journal=Journal of Psychoactive Drugs |url=https://erowid.org/chemicals/pcp/pcp_info7.shtml |via= Erowid.org |date=22 February 2017 |volume=30 |issue=2 |pages=215–219 |doi=10.1080/02791072.1998.10399693 |pmid=9692385 |access-date=30 July 2021}}</ref>
|-
![[Biology:Cannabis (drug)|Cannabis]]
|[[Chemistry:Phencyclidine|PCP]]
|[[Chemistry:Nicotine|Nicotine]]
|
|Wet blunt, dust blunt, dusted blunt, Kendrick Lamar blunt
|Illing
|
|-
! [[Biology:Cocaine|Cocaine]]
| [[Chemistry:Heroin|Heroin]]
|
|
| Snowball. Other names: Belushi, bombita, murder one, whiz bang
| Snowballing
|
|-
! [[Biology:Cocaine|Cocaine]]
| [[Chemistry:Heroin|Heroin]]
| [[Chemistry:LSD|LSD]]
|
| Frisco special<ref name="Erowid" />
|
|
|-
! [[Biology:Cocaine|Cocaine]]
| [[Chemistry:Heroin|Heroin]]
| [[Chemistry:Nicotine|Nicotine]]
|
| Flamethrower, primos
|
| Cigarette laced with cocaine and heroin 
|-
! [[Biology:Cocaine|Cocaine]]
| [[Chemistry:Ketamine|Ketamine]]
|
|
| CK1, Calvin Klein, Cable, Party bag, Coquette 
|
| While CK1, Calvin Klein and Cable are all names for using both substances; a Party bag is in specific reference to when the substances are mixed in a single bag prior to use.
|-
! [[Biology:Cocaine|Cocaine]]
| [[Chemistry:Ketamine|Ketamine]]
| [[Chemistry:MDMA|MDMA]]
|
| Ketamollicaine
|
|
|-
! [[Biology:Cocaine|Cocaine]]
| [[Chemistry:LSD|LSD]]
| [[Chemistry:MDMA|MDMA]]
|
| Candy-flip on a string
| Candy-flipping on a string
| High risk on health

|-
! [[Biology:Cocaine|Cocaine]]
| [[Chemistry:MDMA|MDMA]]
|
|
| Sugar flip
| Sugar flipping
|
|-
! [[Biology:Cocaine|Cocaine]]
| [[Biology:Morphine|Morphine]]
|
|
| C & M
|
|
|-
! [[Biology:Cocaine|Cocaine]]
| [[Chemistry:Phencyclidine|PCP]]
|
|
| Space, whack
|
|
|-
! [[Biology:Cocaine|Cocaine]]
| [[Software:Wine|Wine]]
|
|
| Coca wine
|
| Ethanol is metabolized into [[Chemistry:Cocaethylene|cocaethylene]]
|-
! [[Biology:Cocaine|Cocaine]]
| [[Chemistry:Quetiapine|Quetiapine]]
|
|
| Q-ball
|
|
|-
! [[Chemistry:Codeine|Codeine]]
| [[Chemistry:Glutethimide|Glutethimide]]
|
|
| Pancakes and syrups
|
| Combination of glutethimide and codeine cough syrup 
|-
! [[Chemistry:Codeine|Codeine]]
| [[Chemistry:Promethazine|Promethazine]]
|
|
| [[Chemistry:Lean (drug)|Lean]], purple drank, oil
|
|
|-
! [[Engineering:Crack cocaine|Crack cocaine]]
| [[Chemistry:Fentanyl|Fentanyl]]
|
|
|
|
|-
! [[Engineering:Crack cocaine|Crack cocaine]]
| [[Chemistry:Heroin|Heroin]]
|
|
| Chocolate rock, dragon rock, eightball, moonrock, smoking gun, tar
|
|
|-
! [[Engineering:Crack cocaine|Crack cocaine]]
| [[Chemistry:LSD|LSD]]
|
|
| Cracid, outerlimits
|
|-
! [[Engineering:Crack cocaine|Crack cocaine]]
| [[Chemistry:Methamphetamine|Meth{{shy}}amphetamine]]
|
|
| Fire, twisters
|
|
|-
! [[Engineering:Crack cocaine|Crack cocaine]]
| [[Chemistry:Nicotine|Nicotine]]
|
|
| Coolie, crimmie, woolas
|
|-
! [[Engineering:Crack cocaine|Crack cocaine]]
| [[Chemistry:Nicotine|Nicotine]]
| [[Chemistry:Phencyclidine|PCP]]
|
| Ozone
|
|-
! [[Engineering:Crack cocaine|Crack cocaine]]
| [[Chemistry:Phencyclidine|PCP]]
|
|
| Missile base, P-funk, space base, spaceball, space cadet, space dust, tragic magic
| Missile basing, space basing
|
|-
! [[Chemistry:Diphenhydramine|Diphen{{shy}}hydramine]]
| DXM
|
|
| [[Medicine:Over-the-counter drug|OTC]] flip, counterflipping
| OTC flipping, robowalking on a string
|
|-
! [[Chemistry:N,N-Dimethyltryptamine|DMT]]
| [[Chemistry:LSD|LSD]]
|
|
| Cosmo flip, Meadow flip
| Cosmo flipping, meadow flipping
|
|-
! [[Chemistry:N,N-Dimethyltryptamine|DMT]]
| [[Chemistry:LSD|LSD]]
| [[Chemistry:Psilocybin|Psilocybin]] or [[Biology:Psilocybin mushroom|psilocybin mushroom]]
|
| Super flip
| Super flipping
| Take LSD and shrooms then at the come up smoke DMT
|-
! [[Chemistry:N,N-Dimethyltryptamine|DMT]]
| MAOIs
|
|
| [[Biology:Pharmahuasca|Pharmahuasca]]
|
|
|-
! [[Chemistry:N,N-Dimethyltryptamine|DMT]]
| [[Chemistry:Psilocybin|Psilocybin]] or [[Biology:Psilocybin mushroom|psilocybin mushroom]]
|
|
| Terence flip
| Terence flipping
|
|-
![[Chemistry:N,N-Dimethyltryptamine|DMT]]
|[[Chemistry:Nitrous oxide (medication)|Nitrous oxide]]
|
|
|Dimension flip
|Dimension flipping
|Nitrous oxide can, allegedly, briefly multiply the effects of psychedelics like DMT or NB-DMT<ref name=":4" />
|-
! [[Company:DMT|DMT]]
| [[Chemistry:Alcohol (drug)|Alcohol]]
|
|
| Spyder, Spyder spin
|Spyder spinning
|
|-
! DXM
| [[Chemistry:LSD|LSD]]
|
|
| LSDXM
|
|
|-
! DXM
| [[Chemistry:MDMA|MDMA]]
|
|
| Robo flip
| Robo flipping
|
|-
! DXM
| [[Chemistry:Psilocybin|Psilocybin]] or [[Biology:Psilocybin mushroom|psilocybin mushroom]]
|
|
| Cherry-bomb
| Cherry-bombing
|
|-
! [[Chemistry:Fentanyl|Fentanyl]]
| [[Chemistry:Heroin|Heroin]]
|
|
| Birria, chiva loca, Facebook
|
|-
! [[Chemistry:Fentanyl|Fentanyl]]<br />(and/or heroin)
| [[Chemistry:Xylazine|Xylazine]]
|
|
| Tranq, Tranq dope
|
| "Tranq" is sometimes used to refer to xylazine by itself, but as a drug of abuse it is invariably combined with heroin or fentanyl
|-
! [[Biology:Gamma-Hydroxybutyric acid|GHB]]
| [[Chemistry:MDMA|MDMA]]
|
|
| Gamma flip
| Gamma flipping
|
|-
! [[Biology:Gamma-Hydroxybutyric acid|GHB]]
| [[Chemistry:Methamphetamine|Meth{{shy}}amphetamine]]
|
|
| Cherry meth
|
|
|-
! [[Chemistry:Hashish|Hashish]]
| [[Engineering:Crack cocaine|Crack cocaine]]
|
|
| Double zero
|
|
|-
! [[Chemistry:Hashish|Hashish]]
| [[Chemistry:LSD|LSD]]
|
|
| Royal temple ball
|
| The hashish is mixed with LSD and rolled into a ball intended for oral use, because LSD cannot be smoked.
|-
! [[Chemistry:Hashish|Hashish]]
| [[Biology:Opium|Opium]]
|
|
| Black hash, black Russian
|
|
|-
! [[Chemistry:Heroin|Heroin]]
| [[Chemistry:Methamphetamine|Meth{{shy}}amphetamine]]
|
|
| Goofball
|
|
|-
! [[Chemistry:Heroin|Heroin]]
| [[Biology:Morphine|Morphine]]
|
|
| New Jack swing
|
|
|-
! [[Chemistry:Heroin|Heroin]]
| [[Chemistry:Phencyclidine|PCP]]
|
|
| Alien sex fiend<ref name="Erowid" />
|
|
|-
! [[Chemistry:Ketamine|Ketamine]]
| [[Chemistry:Amphetamine|Amphetamine]]
|
|
| Fruit of the loom<ref>[4pt4axjgzmm4ibmxplfiuvopxzf775e5bqseyllafcecryfthdupjwyd.onion/market Market{{!}}Archetyp]</ref>
|
|
|-
! [[Chemistry:Ketamine|Ketamine]]
| [[Chemistry:LSD|LSD]]
|
|
| Dolphin flip
| Dolphin flipping
|
|-
! [[Chemistry:Ketamine|Ketamine]]
| [[Chemistry:MDMA|MDMA]]
|
|
| Kitty flip,<ref name="Kitty flipping - VICE">{{cite web |last1=Nolan |first1=James |title='Kitty flipping' and the Psychonaut Obsession with Mixing Drugs |url=https://www.vice.com/en_uk/article/mbzbex/kitty-flipping-nexus-flipping-and-the-internets-other-favourite-drug-combos |website=VICE.com |date=8 February 2019 |access-date=16 July 2020}}</ref> MK-ultra
| Kitty flipping
|
|-
! [[Chemistry:Ketamine|Ketamine]]
| [[Chemistry:Psilocybin|Psilocybin]] or Psilocybin mushrooms
|
|
| Funky flip, chonk
| Funky flipping, chonking
| Fungus and K: one confirmed option is to ingest a low (0.75g) dose of psilocybin, wait 45 minutes, snort half a moderate dose of powdered ketamine, wait 10 minutes, snort the other half 
|-
![[Chemistry:LSD|LSD]]
|[[Biology:Caffeine|Caffeine]]
|
|
|Hoffmann<ref>{{Cite web |title=James Hoffmann |url=https://www.youtube.com/channel/UCMb0O2CdPBNi-QqPk5T3gsQ |access-date=2024-06-07 |website=YouTube |language=en}}</ref> Flip
|Hoffmann flipping
|Dose the [[Chemistry:LSD|LSD]] (amount of your choice). After 30 minutes drink 250ml of coffee and keep your usual coffee drinking habit throughout the day.
(Albert Hofmann x James Hoffmann)
|-
! [[Chemistry:LSD|LSD]]
| [[Chemistry:Ketamine|Ketamine]]
| [[Chemistry:MDMA|MDMA]]
|
| Holy Trident, Martin Luther King flip, Galaxy flip
| Holy Tridenting, Martin Luther King flipping, Galaxy Flipping
|
|-
! [[Chemistry:LSD|LSD]]
| [[Chemistry:MDMA|MDMA]]
|
|
| Candy flip<ref name=":2"/><ref name="The base of Ali flipping - Chemical-collective"/>
| Candy flipping<ref name=":1">{{Cite journal |last1=Zeifman |first1=Richard J. |last2=Kettner |first2=Hannes |last3=Pagni |first3=Broc A. |last4=Mallard |first4=Austin |last5=Roberts |first5=Daniel E. |last6=Erritzoe |first6=David |last7=Ross |first7=Stephen |last8=Carhart-Harris |first8=Robin L. |date=2023-08-22 |title=Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences |journal=Scientific Reports |language=en |volume=13 |issue=1 |pages=13645 |doi=10.1038/s41598-023-40856-5 |pmid=37608057 |issn=2045-2322|pmc=10444769 |bibcode=2023NatSR..1313645Z }}</ref><ref name=":2"/><ref name="The base of Ali flipping - Chemical-collective"/>
| Generally, the MDMA is taken approximately 4 hours after the LSD ingestion.
|-
! [[Chemistry:LSD|LSD]]
| [[Chemistry:MDMA|MDMA]]
| [[Chemistry:Psilocybin|Psilocybin]] or [[Biology:Psilocybin mushroom|psilocybin mushroom]]
|
| Jedi flip,<ref name="Kitty flipping - VICE" /> twilight flip
| Jedi flipping, twilight flipping
|
|-
![[Chemistry:LSD|LSD]]
|[[Chemistry:MDMA|MDMA]]
|Mushrooms
|[[Chemistry:Ketamine|Ketamine]]
|Quantum Flip
|Quantum Flipping
|Similar to Jedi flipping, but with a heavy dissociative effect induced by ketamine. The substances are taken in the order of LSD, Mushrooms, MDMA, then ketamine. Each substance should be taken at the peak of the previous substance to maximize the synergistic effects. Ketamine can be re-dosed as needed to extend the trip. The result is a highly visual and euphoric experience with periods of deep dissociation.
|-
! [[Chemistry:LSD|LSD]]
| [[Biology:Mescaline|Mescaline]]
|
|
| Stella trip
|
|
|-
! [[Chemistry:LSD|LSD]]
| [[Chemistry:Nitrous oxide|Nitrous oxide]]
|
|
| Gasid
|
|Nitrous oxide can, allegedly, briefly multiply the effects of psychedelics like LSD.<ref name=":4">{{Cite web |title=Nitrous Oxide |url=https://www.drugscience.org.uk/nitrous-oxide |access-date=2024-10-03 |website=Drug Science |language=en}}</ref>
|-
! [[Chemistry:LSD|LSD]]
| [[Chemistry:Phencyclidine|PCP]]
|
|
| Black acid
|
|
|-
! [[Chemistry:LSD|LSD]]
| [[Chemistry:MDMA|MDMA]]
| [[Chemistry:Ketamine|Ketamine]]
|
| Swalap Flip
| Swalaped
|
|-
! [[Chemistry:LSD|LSD]]
| [[Chemistry:Psilocybin|Psilocybin]] or [[Biology:Psilocybin mushroom|psilocybin mushroom]]
|
|
| God's flesh, Soul Bomb, Alice,<ref name="Erowid" /> Wizard flip
| Wizard flipping
|
|-
![[Chemistry:LSD|LSD]]
|Dissociatives, especially long-lasting ones such as DMXE and/or DCK.
|[[Chemistry:MDMA|MDMA]]
|
|Pixie flip
|Pixie flipping
|
|-
![[Chemistry:LSD|LSD]]
|Dissociatives, especially long-lasting ones such as DMXE and/or DCK.
|[[Chemistry:MDMA|MDMA]]
|[[Company:DMT|DMT]]
|Behind the curtain, portal flip
|Climbing behind the curtain, portal flipping
|DMT is taken last. 
|-
![[Chemistry:LSD|LSD]]
|[[Chemistry:4-HO-MET|Metocin (4-HO-MET)]]
|
|
|Neon Bomb, Diamond Bomb
|Neon Bombing, Diamond Bombing
|Metocin is taken last, usually around onset of LSD. Similar to a Soul Bomb, but because of the lower headspace and body high and higher visual effects of Metocin, the trip is more visual and stimulating. 
|-
! [[Chemistry:MDMA|MDMA]]
| [[Biology:Mescaline|Mescaline]] or [[Biology:Psychoactive cactus|psychoactive cactus]]
|
|
| Love flip, love trip
| Love flipping
|
|-
! [[Chemistry:MDMA|MDMA]]
| [[Chemistry:Methadone|Methadone]]
|
|
| Chocolate flip
| Chocolate flipping
|
|-
! [[Chemistry:MDMA|MDMA]]
| [[Chemistry:Methamphetamine|Meth{{shy}}amphetamine]]
|
|
| Trailer flip
| Trailer flipping
|
|-
! [[Chemistry:MDMA|MDMA]]
| [[Chemistry:N,N-Dimethyltryptamine|DMT]]
|
|
| Shaman flip, time flip
| Shaman flipping, time flipping
|
|-
! [[Chemistry:MDMA|MDMA]]
| [[Chemistry:Nitrous oxide|Nitrous oxide]]
|
|
| Nox
|
|
|-
! [[Chemistry:MDMA|MDMA]]
| Opiates
|
|
| Poppy flip
| Poppy flipping
|
|-
! [[Chemistry:MDMA|MDMA]]
| [[Chemistry:Phencyclidine|PCP]]
|
|
| Domex, elephant flip
| Elephant flipping
|
|-
! [[Chemistry:MDMA|MDMA]]
| [[Chemistry:Psilocybin|Psilocybin]] or [[Biology:Psilocybin mushroom|psilocybin mushroom]]
|
|
|Hippie flip
|Hippie flipping<ref name=":1" />
|
|-
! [[Chemistry:MDMA|MDMA or any]] Empathogen-entactogen
| [[Chemistry:5-MeO-MiPT|5-MeO-MiPT]]
| [[Chemistry:2C-B|2C-B]] or the closely related 2C-x
|
| Selma Flipping
| Selma Flip
| Keep the doses low, as [[Chemistry:5-MeO-MiPT|5-MeO-MiPT]] and Empathogen-entactogen can cause a Serotonin Syndrome at high doses, it's a Nexus Flip enhanced by [[Chemistry:5-MeO-MiPT|5-MeO-MiPT]] for psychedelic, entactogenic & erotic effects. 
|-
! [[Chemistry:MDMA|MDMA]]
| Viagra (or other PDE5 inhibitors such as Cialis or Levitra)
|
|
| Sextacy
|
|
|-
! [[Chemistry:MDMA|MDMA]]
| Xanax
|
|
| Zen flip
| Zen flipping
|
|-
![[Chemistry:MDMA|MDMA]]
|[[Chemistry:Ketamine|Ketamine]]
|Mushrooms
|
|Obama Flip
|Obama Flipping
|
|-
! [[Chemistry:Methamphetamine|Meth{{shy}}amphetamine]]
| [[Chemistry:Secobarbital|Secobarbital]], or other barbiturates
|
|
| Poor man's speedball
|
|
|-
! [[Chemistry:Methamphetamine|Methamphetamine]]
| Alpha-PVP
|
|
| Cartel meth
|
| So-called "cartel meth" is primarily composed of [[Chemistry:Cutting agent|cutting agent]]s such as [[Chemistry:Isopropylbenzylamine|isopropylbenzylamine]] and/or dimethylsulfone with a small proportion of methamphetamine plus the potent stimulant Alpha-PVP
|-
! [[Chemistry:Methaqualone|Methaqualone]]
| [[Biology:Cannabis|Cannabis]]
|
|
| White pipe<ref name="SA">{{Cite web|url=http://www.drugaware.co.za/mandrax.html|title=Mandrax|year=2003|work=DrugAware|publisher=Reality Media|access-date=2009-08-13}}</ref><ref name="Cochrane">{{Cite journal | vauthors = McCarthy G, Myers B, Siegfried N | title = Treatment for methaqualone dependence in adults | journal = The Cochrane Database of Systematic Reviews | issue = 2 | pages = CD004146 | date = April 2005 | pmid = 15846700 | doi = 10.1002/14651858.CD004146.pub2}}</ref>
|
| Ingested by smoking. Popular in South Africa, elsewhere in Africa, and in India.<ref name="Cochrane"/>
|-
! [[Chemistry:Nicotine|Nicotine]]
| [[Chemistry:Phencyclidine|PCP]]
|
|
| Chipping, fry cigarette
|
|
|-
! [[Chemistry:Pentazocine|Pentazocine]]
| Tripelannamine
|
|
| T's and blues
|
|
|-
! [[Chemistry:Venlafaxine|Venlafaxine]]
| Mirtazepine
|
|
| [[Chemistry:California rocket fuel|California rocket fuel]]
|
| None of the drugs are illegal and the combination is used for medical purposes.
|-
|}

==See also==
* [[Chemistry:ACE mixture|ACE mixture]]
* Brompton cocktail
* [[Chemistry:D-IX|D-IX]]
* [[Chemistry:Desbutal|Desbutal]]
* [[Chemistry:Dexamyl|Dexamyl]]
* [[Chemistry:Gray death|Gray death]]
* [[Chemistry:Homebake (slang)|Homebake (slang)]]
* [[Chemistry:Neuroleptanalgesic|Neuroleptanalgesic]]
* Rodent cocktail
* [[Chemistry:Tuinal|Tuinal]]
* [[Medicine:Twilight sleep|Twilight sleep]]
* [[Biology:List of plants used for smoking|List of plants used for smoking]]

==References==
{{Reflist}}

== External links ==
{{Medical resources
|  DiseasesDB     =  
|  ICD10          = {{ICD10|F|19||f|10}} 
|  ICD9           =  
|  ICDO           =  
|  OMIM           =  
|  MedlinePlus    =  
|  eMedicineSubj  =  
|  eMedicineTopic =  
|  MeshID         = 
}}
{{drug use}}
{{Psychoactive substance use}}

{{Combined substance use and adulteration}}

{{DEFAULTSORT:Polysubstance combinations, list of}}
[[Category:Combination drugs]]

{{Sourceattribution|List of polysubstance combinations}}