View source for Medicine:Medical cannabis

{{short description|Marijuana used medicinally}}
{{pp-semi-indef}}

<!-- Definition and medical uses -->
'''Medical cannabis''', or '''medical marijuana''' ('''MMJ'''), is [[Biology:Cannabis (drug)|cannabis]] and [[Chemistry:Cannabinoid|cannabinoid]]s that are [[Medicine:Prescription drug|prescribed]] by [[Medicine:Physician|physician]]s for their patients.<ref>{{cite journal | vauthors = Murnion B | title = Medicinal cannabis | journal = Australian Prescriber | volume = 38 | issue = 6 | pages = 212–15 | date = December 2015 | pmid = 26843715 | pmc = 4674028 | doi = 10.18773/austprescr.2015.072 }}</ref><ref>{{cite web |title= What is medical marijuana? |url= https://www.drugabuse.gov/publications/drugfacts/marijuana-medicine |website= National Institute of Drug Abuse |access-date= 19 April 2016 |date= July 2015 |quote= The term medical marijuana refers to using the whole unprocessed marijuana plant or its basic extracts to treat a disease or symptom. |archive-date= 17 April 2016 |archive-url= https://web.archive.org/web/20160417154854/https://www.drugabuse.gov/publications/drugfacts/marijuana-medicine |url-status= live }}</ref> The use of cannabis as medicine has not been rigorously tested due to production and governmental restrictions, resulting in limited [[Medicine:Clinical research|clinical research]] to define the safety and efficacy of using cannabis to treat diseases.<ref>{{cite journal | title = Release the strains | journal = Nature Medicine | volume = 21 | issue = 9 | pages = 963 | date = September 2015 | pmid = 26340110 | doi = 10.1038/nm.3946 | doi-access = free }}</ref>

Preliminary evidence has indicated that cannabis might reduce nausea and vomiting during [[Medicine:Chemotherapy|chemotherapy]] and reduce [[Medicine:Chronic pain|chronic pain]] and muscle spasms.<ref name=Borgelt2013 /><ref name=JAMA2015 /> Regarding non-inhaled cannabis or cannabinoids, a 2021 review found that it provided little relief against chronic pain and sleep disturbance, and caused several transient [[Medicine:Adverse effect|adverse effect]]s, such as cognitive impairment, nausea, and drowsiness.<ref name="wang2021">{{cite journal | last1=Wang | first1=Li | last2=Hong | first2=Patrick J | last3=May | first3=Curtis | last4=Rehman | first4=Yasir | last5=Oparin | first5=Yvgeniy | last6=Hong | first6=Chris J | last7=Hong | first7=Brian Y | last8=AminiLari | first8=Mahmood | last9=Gallo | first9=Lucas | title=Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials | journal=BMJ | volume=374 | date=2021-09-09 | pages=n1034 | issn=1756-1833 | pmid=34497047 | doi=10.1136/bmj.n1034 | url=https://www.bmj.com/content/374/bmj.n1034 | doi-access=free | access-date=9 September 2021 | archive-date=9 September 2021 | archive-url=https://web.archive.org/web/20210909220904/https://www.bmj.com/content/374/bmj.n1034 | url-status=live }}</ref>

<!-- Side effects -->
Short-term use increases the risk of minor and major adverse effects.<ref name=JAMA2015 /> Common side effects include dizziness, feeling tired, vomiting, and hallucinations.<ref name=JAMA2015 /> Long-term effects of cannabis are not clear.<ref name=JAMA2015 /> Concerns include memory and cognition problems, risk of addiction, [[Medicine:Schizophrenia|schizophrenia]] in young people, and the risk of children taking it by accident.<ref name=Borgelt2013 />

Many cultures have used cannabis for therapeutic purposes for thousands of years.<ref name=BenAmar2006>{{cite journal | vauthors = Ben Amar M | title = Cannabinoids in medicine: A review of their therapeutic potential | journal = Journal of Ethnopharmacology | volume = 105 | issue = 1–2 | pages = 1–25 | date = April 2006 | pmid = 16540272 | doi = 10.1016/j.jep.2006.02.001 | type = Review | citeseerx = 10.1.1.180.308 }}</ref> Some American medical organizations have requested removal of cannabis from the list of Schedule I controlled substances maintained by the United States federal government, followed by regulatory and scientific review.<ref name="ANA" /><ref name="AAFP" /> Others oppose its legalization, such as the American Academy of Pediatrics.<ref name="AAP" />

Medical cannabis can be administered through various methods, including [[Medicine:Capsule (pharmacy)|capsules]], [[Medicine:Throat lozenge|lozenge]]s, [[Medicine:Tincture|tincture]]s, [[Medicine:Dermal patch|dermal patch]]es, oral or dermal sprays, cannabis edibles, and [[Medicine:Vaporizer (inhalation device)|vaporizing]] or smoking dried buds. Synthetic cannabinoids are available for prescription use in some countries, such as [[Biology:Dronabinol|dronabinol]] and [[Chemistry:Nabilone|nabilone]]. Countries that [[Biology:Legality of cannabis|allow the medical use of whole-plant cannabis]] include Argentina, Australia, Canada, Chile, Colombia, Germany, Greece, Israel, Italy, the Netherlands, Peru, Poland, Portugal, Spain, and Uruguay. In the United States, 38 states and the District of Columbia have legalized cannabis for medical purposes, beginning with the passage of California's Proposition 215 in 1996.<ref name="NCSL" /> Although cannabis remains prohibited for any use at the federal level, the Rohrabacher–Farr amendment was enacted in December 2014, limiting the ability of federal law to be enforced in states where medical cannabis has been legalized.

== Classification ==

The [[Organization:National Institute on Drug Abuse|National Institute on Drug Abuse]] defines medical cannabis as "using the whole, unprocessed marijuana plant or its basic extracts to treat symptoms of illness and other conditions".<ref name=nida>{{cite web |publisher= National Institute on Drug Abuse |date= July 2019 |title= Marijuana as Medicine |url= https://www.drugabuse.gov/publications/drugfacts/marijuana-medicine |access-date= 19 April 2016 |archive-date= 17 April 2016 |archive-url= https://web.archive.org/web/20160417154854/https://www.drugabuse.gov/publications/drugfacts/marijuana-medicine |url-status= live }}</ref>

A cannabis plant includes more than 400 different chemicals, of which about 70 are [[Chemistry:Cannabinoid|cannabinoid]]s.<ref name="Consumer Reports April 2016">{{cite web |author1 = Consumer Reports |title = Up in Smoke: Does Medical Marijuana Work? |url = http://www.consumerreports.org/medical-marijuana/does-medical-marijuana-work/ |website = Consumer Reports |access-date = 24 May 2016 |date = 28 April 2016 |archive-date = 14 March 2021 |archive-url = https://web.archive.org/web/20210314045548/https://www.consumerreports.org/medical-marijuana/does-medical-marijuana-work/ |url-status = live }}</ref> In comparison, typical government-approved medications contain only one or two chemicals.<ref name="Consumer Reports April 2016" /> The number of active chemicals in cannabis is one reason why treatment with cannabis is difficult to classify and study.<ref name="Consumer Reports April 2016" />

A 2014 review stated that the variations in ratio of CBD-to-THC in botanical and pharmaceutical preparations determines the therapeutic vs psychoactive effects (CBD attenuates THC's psychoactive effects<ref name="Schubart et al.2014">{{cite journal | vauthors = Schubart CD, Sommer IE, Fusar-Poli P, de Witte L, Kahn RS, Boks MP | title = Cannabidiol as a potential treatment for psychosis | journal = European Neuropsychopharmacology | volume = 24 | issue = 1 | pages = 51–64 | date = January 2014 | pmid = 24309088 | doi = 10.1016/j.euroneuro.2013.11.002 | s2cid = 13197304 | url = http://cannabisclinicians.org/wp-content/uploads/2013/12/CBD-psychosis-2013.pdf | access-date = 9 July 2016 | archive-date = 20 October 2018 | archive-url = https://web.archive.org/web/20181020210452/http://cannabisclinicians.org/wp-content/uploads/2013/12/CBD-psychosis-2013.pdf | url-status = dead }}</ref>) of cannabis products.<ref name="ReferenceA">{{cite journal | vauthors = Koppel BS, Brust JC, Fife T, Bronstein J, Youssof S, Gronseth G, Gloss D | title = Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of Neurology | journal = Neurology | volume = 82 | issue = 17 | pages = 1556–1563 | date = April 2014 | pmid = 24778283 | pmc = 4011465 | doi = 10.1212/WNL.0000000000000363 }}</ref>

== Medical uses ==
[[File:Cannabis sativa (Köhler).jpg|thumb|right|''Cannabis'' as illustrated in Köhler's ''Book of Medicinal Plants'', 1897]]

Overall, research into the health effects of medical cannabis has been of low quality and it is not clear whether it is a useful treatment for any condition, or whether harms outweigh any benefit.<ref name=pratt>{{cite journal |vauthors=Pratt M, Stevens A, Thuku M, Butler C, Skidmore B, Wieland LS, Clemons M, Kanji S, Hutton B |title=Benefits and harms of medical cannabis: a scoping review of systematic reviews |journal=Syst Rev |volume=8 |issue=1 |pages=320 |date=December 2019 |pmid=31823819 |pmc=6905063 |doi=10.1186/s13643-019-1243-x |type=Systematic review |doi-access=free }}</ref> There is no consistent evidence that it helps with [[Medicine:Chronic pain|chronic pain]] and muscle spasms.<ref name=pratt /> 

Low quality evidence suggests its use for reducing [[Chemistry:Antiemetic|nausea]] during [[Medicine:Chemotherapy|chemotherapy]], improving appetite in HIV/AIDS, improving sleep, and improving tics in [[Medicine:Tourette syndrome|Tourette syndrome]].<ref name=JAMA2015>{{cite journal | vauthors = Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, Schmidlkofer S, Westwood M, Kleijnen J | title = Cannabinoids for Medical Use: A Systematic Review and Meta-analysis | journal = JAMA | volume = 313 | issue = 24 | pages = 2456–73 | date = 23 June 2015 | pmid = 26103030 | doi = 10.1001/jama.2015.6358 | doi-access = free | hdl = 10757/558499 | hdl-access = free }}</ref> When usual treatments are ineffective, [[Chemistry:Cannabinoid|cannabinoid]]s have also been recommended for anorexia, [[Medicine:Arthritis|arthritis]], [[Medicine:Glaucoma|glaucoma]],<ref name="Sachs et al. 2015" /> and migraine.<ref name="Distillations">{{cite web |title=Sex(ism), Drugs, and Migraines: Distillations Podcast and Transcript, Episode 237 |date=15 January 2019 |url=https://www.sciencehistory.org/distillations/podcast/sexism-drugs-and-migraines |website=Distillations |publisher=[[Organization:Science History Institute|Science History Institute]] |access-date=28 August 2019 |archive-date=14 March 2021 |archive-url=https://web.archive.org/web/20210314045616/https://www.sciencehistory.org/distillations/podcast/sexism-drugs-and-migraines |url-status=live }}</ref>

It is unclear whether American states might be able to mitigate the adverse effects of the [[Chemistry:Opioid epidemic|opioid epidemic]] by prescribing medical cannabis as an alternative pain management drug.<ref>{{cite journal |last1=Gilson |first1=Aaron M. |last2=LeBaron |first2=Virginia T. |last3=Vyas |first3=Marianne Beare |title=The use of cannabis in response to the opioid crisis: A review of the literature |journal=Nursing Outlook |date=1 January 2018 |volume=66 |issue=1 |pages=56–65 |pmid=28993073 |doi=10.1016/j.outlook.2017.08.012 |issn=0029-6554}}</ref>

Cannabis should not be used in [[Medicine:Pregnancy|pregnancy]].<ref>{{cite journal | author = American College of Obstetricians Gynecologists Committee on Obstetric Practice | title = Committee Opinion No. 637: Marijuana Use During Pregnancy and Lactation | journal = Obstetrics and Gynecology | volume = 126 | issue = 1 | pages = 234–38 | date = July 2015 | pmid = 26241291 | doi = 10.1097/01.AOG.0000467192.89321.a6 }}</ref>

=== Nausea and vomiting ===
Medical cannabis is somewhat effective in [[Medicine:Chemotherapy-induced nausea and vomiting|chemotherapy-induced nausea and vomiting]] (CINV)<ref name=Borgelt2013 /><ref name="Sachs et al. 2015">{{cite journal | vauthors = Sachs J, McGlade E, Yurgelun-Todd D | title = Safety and Toxicology of Cannabinoids | journal = Neurotherapeutics | volume = 12 | issue = 4 | pages = 735–46 | date = October 2015 | pmid = 26269228 | pmc = 4604177 | doi = 10.1007/s13311-015-0380-8 }}</ref> and may be a reasonable option in those who do not improve following preferential treatment.<ref name=Grotenhermen2012 /> Comparative studies have found cannabinoids to be more effective than some conventional antiemetics such as [[Chemistry:Prochlorperazine|prochlorperazine]], [[Chemistry:Promethazine|promethazine]], and [[Chemistry:Metoclopramide|metoclopramide]] in controlling CINV,<ref name=Bowels2012>{{cite journal | vauthors = Bowles DW, O'Bryant CL, Camidge DR, Jimeno A | title = The intersection between cannabis and cancer in the United States | journal = Critical Reviews in Oncology/Hematology | volume = 83 | issue = 1 | pages = 1–10 | date = July 2012 | pmid = 22019199 | doi = 10.1016/j.critrevonc.2011.09.008 | type = Review }}</ref> but these are used less frequently because of side effects including dizziness, dysphoria, and hallucinations.<ref name=Wang2008>{{cite journal | vauthors = Wang T, Collet JP, Shapiro S, Ware MA | title = Adverse effects of medical cannabinoids: a systematic review | journal = CMAJ | volume = 178 | issue = 13 | pages = 1669–78 | date = June 2008 | pmid = 18559804 | pmc = 2413308 | doi = 10.1503/cmaj.071178 | type = Review }}</ref><ref name=Jordan2007>{{cite journal | vauthors = Jordan K, Sippel C, Schmoll HJ | title = Guidelines for antiemetic treatment of chemotherapy-induced nausea and vomiting: past, present, and future recommendations | journal = The Oncologist | volume = 12 | issue = 9 | pages = 1143–50 | date = September 2007 | pmid = 17914084 | doi = 10.1634/theoncologist.12-9-1143 | s2cid = 17612434 | type = Review | url = http://pdfs.semanticscholar.org/d98c/026bda42b4b6ea1b0286d1893b362b46cca4.pdf | archive-url = https://web.archive.org/web/20190307023741/http://pdfs.semanticscholar.org/d98c/026bda42b4b6ea1b0286d1893b362b46cca4.pdf | url-status = dead | archive-date = 2019-03-07 }}</ref> Long-term cannabis use may cause nausea and vomiting, a condition known as [[Medicine:Cannabinoid hyperemesis syndrome|cannabinoid hyperemesis syndrome]] (CHS).<ref name=Nicolson2012>{{cite journal | vauthors = Nicolson SE, Denysenko L, Mulcare JL, Vito JP, Chabon B | title = Cannabinoid hyperemesis syndrome: a case series and review of previous reports | journal = Psychosomatics | volume = 53 | issue = 3 | pages = 212–19 | date = May–Jun 2012 | pmid = 22480624 | doi = 10.1016/j.psym.2012.01.003 | type = Review, case series }}</ref>

A 2016 Cochrane review said that cannabinoids were "probably effective" in treating chemotherapy-induced nausea in children, but with a high side-effect profile (mainly drowsiness, dizziness, altered moods, and increased appetite). Less common side effects were "ocular problems, orthostatic hypotension, muscle twitching, pruritus, vagueness, hallucinations, lightheadedness and dry mouth".<ref>{{cite journal | vauthors = Phillips RS, Friend AJ, Gibson F, Houghton E, Gopaul S, Craig JV, Pizer B | title = Antiemetic medication for prevention and treatment of chemotherapy-induced nausea and vomiting in childhood | journal = The Cochrane Database of Systematic Reviews | volume = 2016 | pages = CD007786 | date = February 2016 | issue = 2 | pmid = 26836199 | doi = 10.1002/14651858.CD007786.pub3 | pmc = 7073407 | url = http://eprints.whiterose.ac.uk/95658/1/Phillips_et_al_2016_The_Cochrane_library.sup_2.pdf | access-date = 23 September 2019 | archive-date = 30 June 2021 | archive-url = https://web.archive.org/web/20210630071713/https://eprints.whiterose.ac.uk/95658/1/Phillips_et_al_2016_The_Cochrane_library.sup_2.pdf | url-status = live }}</ref>

=== HIV/AIDS ===
Evidence is lacking for both efficacy and safety of cannabis and cannabinoids in treating patients with HIV/AIDS or for [[Medicine:Anorexia nervosa|anorexia]] associated with AIDS. As of 2013, current studies suffer from the effects of bias, small sample size, and lack of long-term data.<ref name=Lutge2013>{{cite journal | vauthors = Lutge EE, Gray A, Siegfried N | title = The medical use of cannabis for reducing morbidity and mortality in patients with HIV/AIDS | journal = The Cochrane Database of Systematic Reviews | volume = 4 | issue = 4 | pages = CD005175 | date = April 2013 | pmid = 23633327 | doi = 10.1002/14651858.CD005175.pub3 | type = Review }}</ref>

=== Pain ===
A 2021 review found little effect of using non-inhaled cannabis to relieve chronic pain.<ref name=wang2021/> According to a 2019 systematic review, there have been inconsistent results of using cannabis for neuropathic pain, spasms associated with multiple sclerosis and pain from rheumatic disorders, but was not effective treating chronic cancer pain. The authors state that additional randomized controlled trials of different cannabis products are necessary to make conclusive recommendations.<ref name=pratt/>

When cannabis is inhaled to relieve pain, blood levels of cannabinoids rise faster than when oral products are used, peaking within three minutes and attaining an analgesic effect in seven minutes.<ref name="aviram">{{cite journal | vauthors = Aviram J, Samuelly-Leichtag G | title = Efficacy of Cannabis-Based Medicines for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | journal = Pain Physician | volume = 20 | issue = 6 | pages = E755–96 | date = September 2017 | doi = 10.36076/ppj.20.5.E755 | pmid = 28934780 | url = http://www.painphysicianjournal.com/current/pdf?article=NDYwNA%3D%3D&journal=107 | doi-access = free | access-date = 12 January 2018 | archive-date = 30 June 2021 | archive-url = https://web.archive.org/web/20210630092212/https://www.painphysicianjournal.com/current/pdf?article=NDYwNA%3D%3D&journal=107 | url-status = live }}</ref>

A 2011 review considered cannabis to be generally safe,<ref name=Lyn2011>{{cite journal | vauthors = Lynch ME, Campbell F | title = Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials | journal = British Journal of Clinical Pharmacology | volume = 72 | issue = 5 | pages = 735–44 | date = November 2011 | pmid = 21426373 | pmc = 3243008 | doi = 10.1111/j.1365-2125.2011.03970.x | type = Review }}</ref> and it appears safer than [[Chemistry:Opioid|opioid]]s in palliative care.<ref name=Carter2011>{{cite journal | vauthors = Carter GT, Flanagan AM, Earleywine M, Abrams DI, Aggarwal SK, Grinspoon L | title = Cannabis in palliative medicine: improving care and reducing opioid-related morbidity | journal = The American Journal of Hospice & Palliative Care | volume = 28 | issue = 5 | pages = 297–303 | date = August 2011 | pmid = 21444324 | doi = 10.1177/1049909111402318 | s2cid = 19980960 | type = Review }}</ref>

A 2022 review concluded the pain relief experienced after using medical cannabis is due to the placebo effect, especially given widespread media attention that sets the expectation for pain relief.<ref>{{cite journal |journal=JAMA Network Open |date=November 28, 2022 |title=Placebo Response and Media Attention in Randomized Clinical Trials Assessing Cannabis-Based Therapies for PainA Systematic Review and Meta-analysis |author1=Filip Gedin |author2=Sebastian Blomé |author3=Moa Pontén |author4=Maria Lalouni |author5=Jens Fust |author6=Andreé Raquette |author7=Viktor Vadenmark Lundquist |author8=William H. Thompson |author9=Karin Jensen |volume=5 |issue=11 |pages=e2243848 |doi=10.1001/jamanetworkopen.2022.43848 |pmid=36441553 |pmc=9706362 |doi-access=free }}</ref>

===Neurological conditions===
Cannabis' efficacy is not clear in treating neurological problems, including multiple sclerosis (MS) and movement problems.<ref name="ReferenceA"/> Evidence also suggests that oral cannabis extract is effective for reducing patient-centered measures of spasticity.<ref name="ReferenceA"/> A trial of cannabis is deemed to be a reasonable option if other treatments have not been effective.<ref name=Borgelt2013 />{{By whom|date=April 2017}} Its use for MS is approved in ten countries.<ref name=Borgelt2013 /><ref name=Clark2011>{{cite journal | vauthors = Clark PA, Capuzzi K, Fick C | title = Medical marijuana: medical necessity versus political agenda | journal = Medical Science Monitor | volume = 17 | issue = 12 | pages = RA249–61 | date = December 2011 | pmid = 22129912 | pmc = 3628147 | doi = 10.12659/MSM.882116 | type = Review }}</ref>{{COI source|date=December 2013}} A 2012 review found no problems with tolerance, abuse, or addiction.<ref>{{cite journal | vauthors = Oreja-Guevara C | title = [Treatment of spasticity in multiple sclerosis: new perspectives regarding the use of cannabinoids] | language = es | journal = Revista de Neurología | volume = 55 | issue = 7 | pages = 421–30 | date = October 2012 | pmid = 23011861 | type = Review }}</ref>  In the United States, [[Chemistry:Cannabidiol|cannabidiol]], one of the cannabinoids found in the marijuana plant, has been approved for treating two severe forms of epilepsy, Lennox-Gastaut syndrome and [[Medicine:Dravet syndrome|Dravet syndrome]].<ref name=":4">{{Cite journal|last=Commissioner|first=Office of the|date=2019-06-10|title=FDA and Marijuana|url=https://www.fda.gov/news-events/public-health-focus/fda-and-marijuana|journal=FDA|language=en|access-date=16 December 2019|archive-date=16 November 2019|archive-url=https://web.archive.org/web/20191116160049/https://www.fda.gov/news-events/public-health-focus/fda-and-marijuana|url-status=live}}</ref>

=== Mental disorders ===

A 2019 systematic review found that there is a lack of evidence that cannabinoids are effective in treating depressive or [[Medicine:Anxiety disorder|anxiety disorder]]s, attention-deficit hyperactivity disorder (ADHD), [[Medicine:Tourette syndrome|Tourette syndrome]], [[Medicine:Post-traumatic stress disorder|post-traumatic stress disorder]], or [[Medicine:Psychosis|psychosis]].<ref name=black>{{cite journal |vauthors=Black N, Stockings E, Campbell G, Tran LT, Zagic D, Hall WD, Farrell M, Degenhardt L |title=Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis |journal=Lancet Psychiatry |volume=6 |issue=12 |pages=995–1010 |date=2019 |pmid=31672337 |doi=10.1016/S2215-0366(19)30401-8 |pmc=6949116 |type=Systematic review & meta-analysis}}</ref>

== Adverse effects ==
[[File:American medical hashish(10).jpg|thumb|right|American medical hashish]]

=== Medical use ===
There is insufficient data to draw strong conclusions about the safety of medical cannabis.<ref name=oxpain>{{cite book |first1 = Tabitha A. |last1 = Washington |first2 = Khalilah M. |last2 = Brown |first3 = Gilbert J. |last3 = Fanciullo | name-list-style = vanc |title = Pain |chapter = Chapter 31: Medical Cannabis |page = 165 |year = 2012 |publisher = Oxford University Press |isbn = 978-0-19-994274-9 |quote = Proponents of medical cannabis site its safety, but there studies in later years that support that smoking of marijuana is associated with risk for dependence and that THC alters the structures of cells in the brain }}</ref> Typically, adverse effects of medical cannabis use are not serious;<ref name=Borgelt2013>{{cite journal | vauthors = Borgelt LM, Franson KL, Nussbaum AM, Wang GS | title = The pharmacologic and clinical effects of medical cannabis | journal = Pharmacotherapy | volume = 33 | issue = 2 | pages = 195–209 | date = February 2013 | pmid = 23386598 | doi = 10.1002/phar.1187 | s2cid = 8503107 | url = https://wsma.org/doc_library/LegalResourceCenter/MedicalCannabis/Med%20Mar%20-%20Pharmacologic%20and%20Clinical%20Effects.pdf | access-date = 11 November 2017 | archive-date = 28 August 2021 | archive-url = https://web.archive.org/web/20210828161528/https://wsma.org/doc_library/LegalResourceCenter/MedicalCannabis/Med%20Mar%20-%20Pharmacologic%20and%20Clinical%20Effects.pdf | url-status = live }}</ref> they include tiredness, dizziness, increased appetite, and cardiovascular and psychoactive effects. Other effects can include impaired short-term memory; impaired motor coordination; altered judgment; and paranoia or psychosis at high doses.<ref>{{cite journal | vauthors = Gage SH, Hickman M, Zammit S | title = Association Between Cannabis and Psychosis: Epidemiologic Evidence | journal = Biological Psychiatry | volume = 79 | issue = 7 | pages = 549–56 | date = April 2016 | pmid = 26386480 | doi = 10.1016/j.biopsych.2015.08.001 | hdl = 1983/b8fb2d3b-5a55-4d07-97c0-1650b0ffc05d | s2cid = 1055335 | url = https://research-information.bris.ac.uk/en/publications/association-between-cannabis-and-psychosis(b8fb2d3b-5a55-4d07-97c0-1650b0ffc05d).html | hdl-access = free | access-date = 11 March 2020 | archive-date = 26 February 2020 | archive-url = https://web.archive.org/web/20200226185900/https://research-information.bris.ac.uk/en/publications/association-between-cannabis-and-psychosis(b8fb2d3b-5a55-4d07-97c0-1650b0ffc05d).html | url-status = live }}</ref> Tolerance to these effects develops over a period of days or weeks. The amount of cannabis normally used for medicinal purposes is not believed to cause any permanent cognitive impairment in adults, though long-term treatment in adolescents should be weighed carefully as they are more susceptible to these impairments. Withdrawal symptoms are rarely a problem with controlled medical administration of cannabinoids. The ability to drive vehicles or to operate machinery may be impaired until a tolerance is developed.<ref name=Grotenhermen2012>{{cite journal | vauthors = Grotenhermen F, Müller-Vahl K | title = The therapeutic potential of cannabis and cannabinoids | journal = Deutsches Ärzteblatt International | volume = 109 | issue = 29–30 | pages = 495–501 | date = July 2012 | pmid = 23008748 | pmc = 3442177 | doi = 10.3238/arztebl.2012.0495 }}</ref>  Although supporters of medical cannabis say that it is safe,<ref name=oxpain /> further research is required to assess the long-term safety of its use.<ref name=Wang2008 /><ref name=barceloux866931>{{cite book |first = Donald G |last = Barceloux |title = Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants |chapter = Chapter 60: Marijuana (''Cannabis sativa'' L.) and synthetic cannabinoids |isbn = 978-0-471-72760-6 |year = 2012 |pages = 886–931 |publisher = John Wiley & Sons |chapter-url = https://books.google.com/books?id=OWFiVaDZnkQC&pg=PA886 |access-date = 20 December 2015 |archive-date = 13 January 2023 |archive-url = https://web.archive.org/web/20230113004526/https://books.google.com/books?id=OWFiVaDZnkQC&pg=PA886 |url-status = live }}</ref>

=== Cognitive effects ===
Recreational use of cannabis is associated with cognitive deficits, especially for those who begin to use cannabis in adolescence. {{as of|2021}} there is a lack of research into long-term cognitive effects of medical use of cannabis, but one 12-month observational study reported that "MC patients demonstrated significant improvements on measures of executive function and clinical state over the course of 12 months".<ref>{{cite journal |last1=Sagar |first1=Kelly A. |last2=Dahlgren |first2=M. Kathryn |last3=Lambros |first3=Ashley M. |last4=Smith |first4=Rosemary T. |last5=El-Abboud |first5=Celine |last6=Gruber |first6=Staci A. |title=An Observational, Longitudinal Study of Cognition in Medical Cannabis Patients over the Course of 12 Months of Treatment: Preliminary Results |journal=Journal of the International Neuropsychological Society |date=2021 |volume=27 |issue=6 |pages=648–60 |doi=10.1017/S1355617721000114 |pmid=34261553 |s2cid=235824932 |language=en |issn=1355-6177|doi-access=free }}</ref>

=== Impact on psychosis ===
Exposure to THC can cause acute transient psychotic symptoms in healthy individuals and people with schizophrenia.<ref name="Schubart et al.2014" />

A 2007 meta analysis concluded that cannabis use reduced the average age of onset of psychosis by 2.7 years relative to non-cannabis use.<ref>{{cite journal | vauthors = Large M, Sharma S, Compton MT, Slade T, Nielssen O | title = Cannabis use and earlier onset of psychosis: a systematic meta-analysis | journal = Archives of General Psychiatry | volume = 68 | issue = 6 | pages = 555–61 | date = June 2011 | pmid = 21300939 | doi = 10.1001/archgenpsychiatry.2011.5 | doi-access = free }}</ref>  A 2005 meta analysis concluded that adolescent use of cannabis increases the risk of psychosis, and that the risk is dose-related.<ref>{{cite journal | vauthors = Semple DM, McIntosh AM, Lawrie SM | title = Cannabis as a risk factor for psychosis: systematic review | journal = Journal of Psychopharmacology | volume = 19 | issue = 2 | pages = 187–94 | date = March 2005 | pmid = 15871146 | doi = 10.1177/0269881105049040 | s2cid = 44651274 }}</ref> A 2004 literature review on the subject concluded that cannabis use is associated with a two-fold increase in the risk of psychosis, but that cannabis use is "neither necessary nor sufficient" to cause psychosis.<ref name=Arseneault2004>{{cite journal | vauthors = Arseneault L, Cannon M, Witton J, Murray RM | title = Causal association between cannabis and psychosis: examination of the evidence | journal = The British Journal of Psychiatry | volume = 184 | issue = 2 | pages = 110–17 | date = February 2004 | pmid = 14754822 | doi = 10.1192/bjp.184.2.110 | doi-access = free }}</ref> A French review from 2009 came to a conclusion that cannabis use, particularly that before age 15, was a factor in the development of schizophrenic disorders.<ref name="Laqueille">{{cite journal | vauthors = Laqueille X | title = [Is cannabis a vulnerability factor in schizophrenic disorders] | journal = Archives de Pédiatrie | volume = 16 | issue = 9 | pages = 1302–05 | date = September 2009 | pmid = 19640690 | doi = 10.1016/j.arcped.2009.03.016 | trans-title = Is cannabis is a vulnerability factor of schizophrenic disorders?  }}</ref>

== Pharmacology ==
The [[Biology:Genus|genus]] ''[[Biology:Cannabis|Cannabis]]'' contains two species which produce useful amounts of psychoactive cannabinoids: ''[[Biology:Cannabis indica|Cannabis indica]]'' and ''[[Biology:Cannabis sativa|Cannabis sativa]]'', which are listed as Schedule I medicinal plants in the US;<ref name=Borgelt2013 /> a third species, ''[[Biology:Cannabis ruderalis|Cannabis ruderalis]]'', has few psychogenic properties.<ref name=Borgelt2013 /> Cannabis contains more than 460 compounds;<ref name=BenAmar2006 /> at least 80 of these are [[Chemistry:Cannabinoid|cannabinoid]]s<ref>{{cite journal | vauthors = Downer EJ, Campbell VA | title = Phytocannabinoids, CNS cells and development: a dead issue? | journal = Drug and Alcohol Review | volume = 29 | issue = 1 | pages = 91–98 | date = January 2010 | pmid = 20078688 | doi = 10.1111/j.1465-3362.2009.00102.x | type = Review }}</ref><ref>{{cite journal | vauthors = Burns TL, Ineck JR | title = Cannabinoid analgesia as a potential new therapeutic option in the treatment of chronic pain | journal = The Annals of Pharmacotherapy | volume = 40 | issue = 2 | pages = 251–60 | date = February 2006 | pmid = 16449552 | doi = 10.1345/aph.1G217 | s2cid = 6858360 | type = Review }}</ref> – [[Chemistry:Chemical compound|chemical compound]]s that interact with [[Biology:Cannabinoid receptor|cannabinoid receptor]]s in the brain.<ref name=Borgelt2013 /> As of 2012, more than 20 cannabinoids were being studied by the U.S. FDA.<ref name=Svrakic2012>{{cite journal | vauthors = Svrakic DM, Lustman PJ, Mallya A, Lynn TA, Finney R, Svrakic NM | title = Legalization, decriminalization & medicinal use of cannabis: a scientific and public health perspective | journal = Missouri Medicine | volume = 109 | issue = 2 | pages = 90–98 | year = 2012 | pmid = 22675784 | pmc = 6181739 | type = Review }}</ref>

The most psychoactive cannabinoid found in the cannabis plant is [[Biology:Tetrahydrocannabinol|tetrahydrocannabinol]] (or delta-9-tetrahydrocannabinol, commonly known as THC).<ref name=BenAmar2006 /> Other cannabinoids include delta-8-tetrahydrocannabinol, [[Chemistry:Cannabidiol|cannabidiol]] (CBD), [[Chemistry:Cannabinol|cannabinol]] (CBN), [[Chemistry:Cannabicyclol|cannabicyclol]] (CBL), [[Chemistry:Cannabichromene|cannabichromene]] (CBC) and [[Chemistry:Cannabigerol|cannabigerol]] (CBG); they have less psychotropic effects than THC, but may play a role in the overall effect of cannabis.<ref name=BenAmar2006 /> The most studied are THC, CBD and CBN.<ref name=Gordon2013>{{cite journal | vauthors = Gordon AJ, Conley JW, Gordon JM | title = Medical consequences of marijuana use: a review of current literature | journal = Current Psychiatry Reports | volume = 15 | issue = 12 | pages = 419 | date = December 2013 | pmid = 24234874 | doi = 10.1007/s11920-013-0419-7 | s2cid = 29063282 | type = Review | url = https://zenodo.org/record/1232874 | access-date = 12 July 2019 | archive-date = 7 August 2019 | archive-url = https://web.archive.org/web/20190807172632/https://zenodo.org/record/1232874 | url-status = live }}</ref>

CB1 and CB2 are the primary cannabinoid receptors responsible for several of the effects of cannabinoids, although other receptors may play a role as well. Both belong to a group of receptors called G protein-coupled receptors (GPCRs). CB1 receptors are found in very high levels in the brain and are thought to be responsible for psychoactive effects.<ref>{{cite journal | vauthors = Mackie K | title = Cannabinoid receptors: where they are and what they do | journal = Journal of Neuroendocrinology | volume = 20 | pages = 10–14 | date = May 2008 | issue = Suppl 1 | pmid = 18426493 | doi = 10.1111/j.1365-2826.2008.01671.x | s2cid = 20161611 | doi-access = free }}</ref> CB2 receptors are found peripherally throughout the body and are thought to modulate pain and inflammation.<ref>{{cite journal | vauthors = Whiteside GT, Lee GP, Valenzano KJ | title = The role of the cannabinoid CB2 receptor in pain transmission and therapeutic potential of small molecule CB2 receptor agonists | journal = Current Medicinal Chemistry | volume = 14 | issue = 8 | pages = 917–36 | date = 2007 | pmid = 17430144 | doi = 10.2174/092986707780363023 }}</ref>

=== Absorption ===
Cannabinoid absorption is dependent on its route of administration.

Inhaled and vaporized THC have similar absorption profiles to smoked THC, with a [[Chemistry:Bioavailability|bioavailability]] ranging from 10 to 35%. Oral administration has the lowest bioavailability of approximately 6%, variable absorption depending on the vehicle used, and the longest time to peak plasma levels  (2 to 6 hours) compared to smoked or vaporized THC.<ref name=":0">{{cite journal | vauthors = Gaston TE, Friedman D | title = Pharmacology of cannabinoids in the treatment of epilepsy | journal = Epilepsy & Behavior | volume = 70 | issue = Pt B | pages = 313–18 | date = May 2017 | pmid = 28087250 | doi = 10.1016/j.yebeh.2016.11.016 | series = Cannabinoids and Epilepsy | s2cid = 3929024 }}</ref>

Similar to THC, CBD has poor oral bioavailability, approximately 6%. The low bioavailability is largely attributed to significant first-pass metabolism in the liver and erratic absorption from the gastrointestinal tract. However, oral administration of CBD has a faster time to peak concentrations (2 hours) than THC.<ref name=":0" />

Due to the poor bioavailability of oral preparations, alternative routes of administration have been studied, including sublingual and rectal. These alternative formulations maximize bioavailability and reduce first-pass metabolism. Sublingual administration in rabbits yielded bioavailability of 16% and time to peak concentration of 4 hours.<ref>{{cite journal | vauthors = Mannila J, Järvinen T, Järvinen K, Tervonen J, Jarho P | title = Sublingual administration of Delta9-tetrahydrocannabinol/beta-cyclodextrin complex increases the bioavailability of Delta9-tetrahydrocannabinol in rabbits | journal = Life Sciences | volume = 78 | issue = 17 | pages = 1911–14 | date = March 2006 | pmid = 16266727 | doi = 10.1016/j.lfs.2005.08.025 }}</ref> Rectal administration in monkeys doubled bioavailability to 13.5% and achieved peak blood concentrations within 1 to 8 hours after administration.<ref name=":1">{{cite journal | vauthors = Huestis MA | title = Human cannabinoid pharmacokinetics | journal = Chemistry & Biodiversity | volume = 4 | issue = 8 | pages = 1770–804 | date = August 2007 | pmid = 17712819 | pmc = 2689518 | doi = 10.1002/cbdv.200790152 }}</ref>

=== Distribution ===
Like cannabinoid absorption, distribution is also dependent on route of administration. Smoking and inhalation of vaporized cannabis have better absorption than do other routes of administration, and therefore also have more predictable distribution.<ref name=":1" /><ref name=":3">{{cite journal | vauthors = Badowski ME | title = A review of oral cannabinoids and medical marijuana for the treatment of chemotherapy-induced nausea and vomiting: a focus on pharmacokinetic variability and pharmacodynamics | journal = Cancer Chemotherapy and Pharmacology | volume = 80 | issue = 3 | pages = 441–49 | date = September 2017 | pmid = 28780725 | pmc = 5573753 | doi = 10.1007/s00280-017-3387-5 }}</ref> THC is highly protein bound once absorbed, with only 3% found unbound in the plasma. It distributes rapidly to highly vascularized organs such as the heart, lungs, liver, spleen, and kidneys, as well as to various glands. Low levels can be detected in the brain, testes, and unborn fetuses, all of which are protected from systemic circulation via barriers.<ref>{{cite journal | vauthors = Nahas GG | title = The pharmacokinetics of THC in fat and brain: resulting functional responses to marihuana smoking | journal = Human Psychopharmacology | volume = 16 | issue = 3 | pages = 247–55 | date = April 2001 | pmid = 12404577 | doi = 10.1002/hup.258 | s2cid = 30513770 }}</ref> THC further distributes into fatty tissues a few days after administration due to its high lipophilicity, and is found deposited in the spleen and fat after redistribution.<ref name=":3" /><ref>{{cite journal | vauthors = Bridgeman MB, Abazia DT | title = Medicinal Cannabis: History, Pharmacology, And Implications for the Acute Care Setting | journal = P & T | volume = 42 | issue = 3 | pages = 180–88 | date = March 2017 | pmid = 28250701 | pmc = 5312634 }}</ref><ref>{{Cite book|url=https://books.google.com/books?id=AYH5BwAAQBAJ&pg=PA91|title=Marihuana and Medicine|last1=Nahas|first1=Gabriel G.|last2=Sutin|first2=Kenneth M.|last3=Harvey|first3=David J.|last4=Agurell|first4=Stig|name-list-style=vanc|year=1999|publisher=Springer Science & Business Media|isbn=978-1-59259-710-9|access-date=20 September 2020|archive-date=13 January 2023|archive-url=https://web.archive.org/web/20230113004528/https://books.google.com/books?id=AYH5BwAAQBAJ&pg=PA91|url-status=live}}</ref>

=== Metabolism ===
Delta-9-THC is the primary molecule responsible for the effects of cannabis. Delta-9-THC is metabolized in the liver and turns into 11-OH-THC.<ref name=":2">{{Cite news|url=https://sapiensoup.com/human-metabolism-thc|title=Human Metabolism of THC|date=2016-12-21|work=Sapiensoup Blog|access-date=2017-11-01|language=en-US|archive-date=26 June 2021|archive-url=https://web.archive.org/web/20210626101148/https://sapiensoup.com/human-metabolism-thc|url-status=live}}</ref>&nbsp;11-OH-THC is the first metabolic product in this pathway. Both Delta-9-THC and 11-OH-THC are psychoactive. The metabolism of THC into 11-OH-THC plays a part in the heightened psychoactive effects of edible cannabis.<ref>{{Cite web|url=http://profofpot.com/11-hydroxy-tetrahydrocannabinol-potency-edibles/|title=11-Hydroxy-THC - Increased Potency That Explains the Effect of Edibles? – Prof of Pot|website=profofpot.com|date=2 July 2016|language=en-US|access-date=2017-11-01|archive-date=28 June 2021|archive-url=https://web.archive.org/web/20210628171055/https://profofpot.com/11-hydroxy-tetrahydrocannabinol-potency-edibles/|url-status=dead}}</ref>

Next, 11-OH-THC is metabolized in the liver into 11-COOH-THC, which is the second metabolic product of THC.<ref>{{Cite web|url=http://www.consultox.com/toxicology-marijuana.shtml|title=Toxicology Litigation Support: Marijuana|website=consultox.com|access-date=2017-11-01|archive-date=26 June 2021|archive-url=https://web.archive.org/web/20210626101148/http://www.consultox.com/toxicology-marijuana.shtml|url-status=live}}</ref>&nbsp;11-COOH-THC is not psychoactive.<ref name=":2" />

Ingestion of edible cannabis products lead to a slower onset of effect than the inhalation of it because the THC travels to the liver first through the blood before it travels to the rest of the body. Inhaled cannabis can result in THC going directly to the brain, where it then travels from the brain back to the liver in recirculation for metabolism.<ref name=":2" /> Eventually, both routes of metabolism result in the metabolism of psychoactive THC to inactive 11-COOH-THC.

=== Excretion ===
Due to substantial metabolism of THC and CBD, their metabolites are excreted mostly via [[Biology:Feces|feces]], rather than by urine.<ref name=":0" /><ref name="devinsky">{{cite journal | vauthors = Devinsky O, Cilio MR, Cross H, Fernandez-Ruiz J, French J, Hill C, Katz R, Di Marzo V, Jutras-Aswad D, Notcutt WG, Martinez-Orgado J, Robson PJ, Rohrback BG, Thiele E, Whalley B, Friedman D | title = Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders | journal = Epilepsia | volume = 55 | issue = 6 | pages = 791–802 | date = June 2014 | pmid = 24854329 | pmc = 4707667 | doi = 10.1111/epi.12631 }}</ref> After delta-9-THC is hydroxylated into 11-OH-THC via CYP2C9, CYP2C19, and CYP3A4, it undergoes phase II metabolism into more than 30 metabolites, a majority of which are products of [[Chemistry:Glucuronidation|glucuronidation]]. Approximately 65% of THC is excreted in feces and 25% in the urine, while the remaining 10% is excreted by other means.<ref name=":0" /> The terminal half-life of THC is 25 to 36 hours,<ref>{{cite journal | vauthors = Grotenhermen F | title = Pharmacokinetics and pharmacodynamics of cannabinoids | journal = Clinical Pharmacokinetics | volume = 42 | issue = 4 | pages = 327–60 | date = 2003-04-01 | pmid = 12648025 | doi = 10.2165/00003088-200342040-00003 | s2cid = 25623600 }}</ref> whereas for CBD it is 18 to 32 hours.<ref name=devinsky/>

CBD is hydroxylated by P450 liver enzymes into 7-OH-CBD. Its metabolites are products of primarily CYP2C19 and CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6.<ref>{{Cite journal|last=Juřica|first=Ondřej Zendulka, Gabriela Dovrtělová, Kristýna Nosková, Miroslav Turjap, Alexandra Šulcová, Lumír Hanuš and Jan|date=2016-02-29|title=Cannabinoids and Cytochrome P450 Interactions|url=http://www.eurekaselect.com/137749/article|journal=Current Drug Metabolism|language=en|volume=17|issue=3|pages=206–226|doi=10.2174/1389200217666151210142051|pmid=26651971|access-date=1 November 2017|archive-date=3 July 2021|archive-url=https://web.archive.org/web/20210703094804/https://www.eurekaselect.com/137749/article|url-status=live}}</ref> Similar to delta-9-THC, a majority of CBD is excreted in feces and some in the urine.<ref name=":0" /> The terminal half-life is approximately 18–32 hours.<ref>{{cite journal | vauthors = Ohlsson A, Lindgren JE, Andersson S, Agurell S, Gillespie H, Hollister LE | title = Single-dose kinetics of deuterium-labelled cannabidiol in man after smoking and intravenous administration | journal = Biomedical & Environmental Mass Spectrometry | volume = 13 | issue = 2 | pages = 77–83 | date = February 1986 | pmid = 2937482 | doi = 10.1002/bms.1200130206 }}</ref>

== Administration ==
[[File:Blausen 0158 Cannabis Medicinal.png|thumb|left|Illustrating various forms of medicinal cannabis]]

[[Medicine:Smoking|Smoking]] has been the means of administration of cannabis for many users, but it is not suitable for the use of cannabis as a medicine.<ref name=CurtisClarke2009>{{cite journal | vauthors = Curtis A, Clarke CE, Rickards HE | title = Cannabinoids for Tourette's Syndrome | journal = The Cochrane Database of Systematic Reviews | issue = 4 | pages = CD006565 | date = October 2009 | volume = 2009 | pmid = 19821373 | doi = 10.1002/14651858.CD006565.pub2 | type = Review  | pmc = 7387115 }}</ref> It was the most common method of medical cannabis consumption in the US {{asof|lc=yes|2013}}.<ref name=Borgelt2013 /> It is difficult to predict the pharmacological response to cannabis because concentration of cannabinoids varies widely, as there are different ways of preparing it for consumption (smoked, applied as oils, eaten, infused into other foods,  or drunk) and a lack of production controls.<ref name=Borgelt2013 /> The potential for adverse effects from smoke inhalation makes smoking a less viable option than oral preparations.<ref name=CurtisClarke2009 /> Cannabis vaporizers have gained popularity because of a perception among users that fewer harmful chemicals are ingested when components are inhaled via aerosol rather than smoke.<ref name=Borgelt2013 /> Cannabinoid medicines are available in pill form ([[Biology:Dronabinol|dronabinol]] and [[Chemistry:Nabilone|nabilone]]) and liquid extracts formulated into an oromucosal spray ([[Chemistry:Nabiximols|nabiximols]]).<ref name=Borgelt2013 /> Oral preparations are "problematic due to the uptake of cannabinoids into fatty tissue, from which they are released slowly, and the significant first-pass liver metabolism, which breaks down Δ9THC and contributes further to the variability of plasma concentrations".<ref name=CurtisClarke2009 />

The US Food and Drug Administration (FDA) has not approved smoked cannabis for any condition or disease, as it deems that evidence is lacking concerning safety and efficacy.<ref name=FDA2006 /> The FDA issued a 2006 advisory against ''smoked'' medical cannabis stating: "marijuana has a high potential for abuse, has no currently accepted medical use in treatment in the United States, and has a lack of accepted safety for use under medical supervision."<ref name=FDA2006>{{Cite press release |url = https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2006/ucm108643.htm |title = Inter-agency advisory regarding claims that smoked marijuana is a medicine |publisher = fda.gov |date = 20 April 2006 |access-date = 24 December 2012 |archive-date = 13 October 2012 |archive-url = https://web.archive.org/web/20121013080059/http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2006/ucm108643.htm |url-status = live }}</ref>

== History ==

=== Ancient ===
Cannabis, called ''má'' 麻 (meaning "hemp; cannabis; numbness") or ''dàmá'' 大麻 (with "big; great") in Chinese, was used in Taiwan for fiber starting about 10,000 years ago.<ref>{{Cite book |first = Ernest L. |last = Abel |year = 1980 |chapter = Cannabis in the Ancient World |chapter-url = http://www.druglibrary.org/schaffer/hemp/history/first12000/1.htm |title = Marihuana: the first twelve thousand years |publisher = Plenum Publishers |location = New York City |isbn = 978-0-306-40496-2 |access-date = 29 October 2008 |archive-date = 28 June 2021 |archive-url = https://web.archive.org/web/20210628135448/https://www.druglibrary.org/schaffer/hemp/history/first12000/1.htm |url-status = live }}{{Page needed|date=August 2010}}</ref> The botanist Hui-lin Li wrote that in China, "The use of Cannabis in medicine was probably a very early development. Since ancient humans used hemp seed as food, it was quite natural for them to also discover the medicinal properties of the plant."<ref>Li, Hui-Lin (1974). "An Archaeological and Historical Account of Cannabis in China", ''Economic Botany'' 28.4:437–48, p. 444.</ref> Emperor Shen-Nung, who was also a pharmacologist, wrote a book on treatment methods in 2737 BCE that included the medical benefits of cannabis. He recommended the substance for many ailments, including constipation, gout, rheumatism, and absent-mindedness.<ref name=autogenerated2>{{cite book |last = Bloomquist |first = Edward |title = Marijuana: The Second Trip |year = 1971 |publisher = Glencoe Press |location = California }}</ref> Cannabis is one of the 50 "fundamental" herbs in [[Medicine:Traditional Chinese medicine|traditional Chinese medicine]].<ref name="Wong">{{Cite book |last = Wong |first = Ming |year = 1976 |title = La Médecine chinoise par les plantes |publisher = Tchou |location = Paris |oclc = 2646789 }}{{Page needed|date=August 2010}}</ref>

The [[Chemistry:Ebers Papyrus|Ebers Papyrus]] ({{circa|1550 BCE}}) from Ancient Egypt describes medical cannabis.<ref name="ebers">{{unreliable source?|date=December 2013}} {{cite web |url = http://www.onlinepot.org/medical/eberspapyrus.htm |title = The Ebers Papyrus The Oldest (confirmed) Written Prescriptions For Medical Marihuana era 1,550 BC |publisher = onlinepot.org |access-date = 10 June 2008 |archive-date = 4 March 2016 |archive-url = https://web.archive.org/web/20160304080726/http://www.onlinepot.org/medical/eberspapyrus.htm |url-status = dead }}</ref> The ancient Egyptians used hemp (cannabis) in suppositories for relieving the pain of [[Medicine:Hemorrhoid|hemorrhoid]]s.<ref>{{Cite news |url = https://www.newscientist.com/channel/health/mg19626341.600-the-pharaohs-pharmacists.html |title = The Pharaoh's pharmacists |last = Pain |first = Stephanie |date = 15 December 2007 |work = New Scientist |publisher = Reed Business Information Ltd. |access-date = 4 September 2017 |archive-date = 21 May 2008 |archive-url = https://web.archive.org/web/20080521162813/http://www.newscientist.com/channel/health/mg19626341.600-the-pharaohs-pharmacists.html |url-status = live }}</ref>

Surviving texts from ancient India confirm that cannabis' psychoactive properties were recognized, and doctors used it for treating a variety of illnesses and ailments, including insomnia, headaches, gastrointestinal disorders, and pain, including during childbirth.<ref>{{cite journal | vauthors = Touw M | title = The religious and medicinal uses of Cannabis in China, India and Tibet | journal = Journal of Psychoactive Drugs | volume = 13 | issue = 1 | pages = 23–34 | year = 1981 | pmid = 7024492 | doi = 10.1080/02791072.1981.10471447 }}</ref>

The Ancient Greeks used cannabis to dress wounds and sores on their horses,<ref name="hawthorne">{{cite journal |doi = 10.1300/J175v02n02_04 |title = The Medical Use of Cannabis Among the Greeks and Romans |year = 2002 |last1 = Butrica |first1 = James L. |journal = Journal of Cannabis Therapeutics |volume = 2 |issue = 2 |pages = 51–70 |url = http://www.cannabis-med.org/data/pdf/2002-02-3.pdf |access-date = 8 November 2014 |archive-date = 11 November 2014 |archive-url = https://web.archive.org/web/20141111224607/http://www.cannabis-med.org/data/pdf/2002-02-3.pdf |url-status = dead }}</ref> and in humans, dried leaves of cannabis were used to treat nose bleeds, and cannabis seeds were used to expel tapeworms.<ref name="hawthorne" />

In the medieval Islamic world, Arabic physicians made use of the [[Chemistry:Diuretic|diuretic]], [[Chemistry:Antiemetic|antiemetic]], antiepileptic, [[Chemistry:Anti-inflammatory|anti-inflammatory]], [[Biology:Analgesic|analgesic]] and [[Chemistry:Antipyretic|antipyretic]] properties of ''[[Biology:Cannabis sativa|Cannabis sativa]]'', and used it extensively as medication from the 8th to 18th centuries.<ref>{{cite journal |doi = 10.1300/J175v01n01_05 |title = The Therapeutic Use of Cannabis sativa (L.) in Arabic Medicine |year = 2001 |last1 = Lozano |first1 = Indalecio |journal = Journal of Cannabis Therapeutics |volume = 1 |pages = 63–70 |citeseerx = 10.1.1.550.1717 }}</ref>

=== Landrace strains ===
[[File:The Three Cultivars of the Cannabis Plant.png|thumb|Evolution of cultivated cannabis strains. The [[Biology:Cultivar|cultivar]], ''Cannabis ruderalis'', still grows wild today.]]

Cannabis seeds may have been used for food, rituals or religious practices in ancient Europe and China.<ref name = "Holland_2018">{{cite book|editor=Holland, Julie|title=The Pot Book: A Complete Guide to Cannabis|date=2010|publisher=Simon and Schuster|location=New York|isbn=978-1594778988|access-date=22 April 2018|url=https://books.google.com/books?id=tV0oDwAAQBAJ|archive-date=13 January 2023|archive-url=https://web.archive.org/web/20230113004529/https://books.google.com/books?id=tV0oDwAAQBAJ|url-status=live}}</ref>{{rp|19–22}} Harvesting the plant led to the spread of cannabis throughout [[Earth:Eurasia|Eurasia]] about 10,000 to 5,000 years ago, with further distribution to the [[Place:Middle East|Middle East]] and Africa about 2,000 to 500 years ago.<ref name = "Holland_2018" />{{rp|18–19}} A [[Biology:Landrace|landrace]] [[Biology:Strain|strain]] of cannabis developed over centuries.<ref>{{cite book|last1=Evert|first1=Ray F.|last2=Eichhorn|first2=Susan E. | name-list-style = vanc |title=Raven Biology of Plants|date=2013|publisher=W. H. Freeman and Company|location=New York|isbn=978-1-4292-1961-7|pages=213–17|edition=8th}}</ref> They are cultivars of the plant that originated in one specific region.

Widely cultivated strains of cannabis, such as "Afghani" or "Hindu Kush", are indigenous to the {{wipe|Pakistan}} and Afghanistan regions, while "Durban Poison" is native to Africa.<ref name = "Holland_2018" />{{rp|45–48}} There are approximately 16 landrace strains of cannabis identified from Pakistan, Jamaica, Africa, Mexico, Central America and Asia.<ref>{{cite book|last1=Evert|first1=Ray F.|last2=Eichhorn|first2=Susan E. | name-list-style = vanc |title=Raven Biology of Plants|date=2013|publisher=W.H. Freeman and Company|location=New York|isbn=9781429219617|pages=501–04|edition=8th}}</ref>

=== Modern ===
An Irish physician, William Brooke O'Shaughnessy, is credited with introducing cannabis to Western medicine.<ref name=Mack>{{cite book |author1 = Alison Mack |author2 = Janet Joy |title = Marijuana As Medicine?: The Science Beyond the Controversy |url = https://books.google.com/books?id=ZriSkC7aQOEC&pg=PA15 |year = 2000 |publisher = National Academies Press |isbn = 978-0-309-06531-3 |pages = 15– |access-date = 20 December 2015 |archive-date = 13 January 2023 |archive-url = https://web.archive.org/web/20230113004529/https://www.google.com/books/edition/Marijuana_As_Medicine/ZriSkC7aQOEC?hl=en&gbpv=1&pg=PA15&printsec=frontcover |url-status = live }}</ref> O'Shaughnessy discovered cannabis in the 1830s while living abroad in {{wipe|India}}, where he conducted numerous experiments investigating the drug's medical utility (noting in particular its [[Biology:Analgesic|analgesic]] and [[Chemistry:Anticonvulsant|anticonvulsant]] effects).<ref name="Booth">{{cite book |last1 = Booth |first1 = Martin |title = Cannabis: A History |year=2005 |publisher = St. Martin's Press |location = New York |isbn = 978-0-312-42494-7 }}</ref>  He returned to {{wipe|England}} with a supply of cannabis in 1842, after which its use spread through Europe and the United States.<ref name="Grinspoon">{{cite book |last1 = Grinspoon |first1 = Lester |last2 = Bakalar |first2 = James | name-list-style = vanc |title = Marihuana, the Forbidden Medicine |date = 1997 |publisher = Yale University Press |isbn = 978-0-300-07086-6 |edition = Revised and expanded }}</ref>  In 1845 French physician Jacques-Joseph Moreau published a book about the use of cannabis in psychiatry.<ref>Hans Bangen:''Geschichte der medikamentösen Therapie der Schizophrenie.'' Berlin 1992, p. 22.</ref>  In 1850 cannabis was entered into the United States Pharmacopeia.<ref name="Booth" /> An anecdotal report of ''[[Biology:Cannabis indica|Cannabis indica]]'' as a treatment for [[Medicine:Tetanus|tetanus]] appeared in Scientific American in 1880.<ref>{{Cite book|url=https://books.google.com/books?id=6ok9AQAAIAAJ|title=Scientific American, "Successful Treatment of Tetanus"|date=1880-07-10|publisher=Munn & Company|pages=25|language=en|access-date=5 June 2021|archive-date=12 January 2023|archive-url=https://web.archive.org/web/20230112202810/https://books.google.com/books?id=6ok9AQAAIAAJ|url-status=live}}</ref>

The use of cannabis in medicine began to decline by the end of the 19th century, due to difficulty in controlling dosages and the rise in popularity of synthetic and [[Biology:Opium|opium]]-derived drugs.<ref name="Grinspoon" />  Also, the advent of the hypodermic [[Engineering:Syringe|syringe]] allowed these drugs to be injected for immediate effect, in contrast to cannabis which is not water-soluble and therefore cannot be injected.<ref name="Grinspoon" />

In the United States, the medical use of cannabis further declined with the passage of the Marihuana Tax Act of 1937, which imposed new regulations and fees on physicians prescribing cannabis.<ref>{{cite journal |last1 = Pacula |first1 = Rosalie Piccardo |title = State Medical Marijuana Laws: Understanding the Laws and Their Limitations |journal = Journal of Public Health Policy |date = February 2002 |doi = 10.2307/3343240 |url = http://impacteen.uic.edu/generalarea_PDFs/medicalmarijuanapaper100301.pdf |volume = 23 |issue = 4 |pages = 413–39 |jstor = 3343240 |pmid = 12532682 |citeseerx = 10.1.1.202.2274 |s2cid = 13389317 |access-date = 20 March 2018 |archive-date = 2 March 2021 |archive-url = https://web.archive.org/web/20210302173927/https://impacteen.uic.edu/generalarea_PDFs/medicalmarijuanapaper100301.pdf |url-status = live }}</ref>  Cannabis was removed from the U.S. Pharmacopeia in 1941, and officially banned for any use with the passage of the Controlled Substances Act of 1970.<ref name="Grinspoon" />

Cannabis began to attract renewed interest as medicine in the 1970s and 1980s, in particular due to its use by cancer and AIDS patients who reported relief from the effects of [[Medicine:Chemotherapy|chemotherapy]] and [[Medicine:Cachexia|wasting syndrome]].<ref>{{cite news |last1 = Joy |first1 = Janet E. |last2 = Watson |first2 = Stanley J. |last3 = Benson |first3 = John A. |name-list-style = vanc |title = Marijuana and Medicine – Assessing the Science Base |url = http://medicalmarijuana.procon.org/sourcefiles/IOM_Report.pdf |publisher = National Academy Press |location = Washington, D.C. |date = 1999 |access-date = 28 July 2017 |archive-url = https://web.archive.org/web/20180123184348/https://medicalmarijuana.procon.org/sourcefiles/IOM_Report.pdf |archive-date = 23 January 2018 |url-status = dead }}</ref>  In 1996, {{wipe|California}} became the first U.S. state to legalize medical cannabis in defiance of federal law.<ref>{{cite web |title = History of Marijuana as Medicine – 2900 BC to Present |url = http://medicalmarijuana.procon.org/view.timeline.php?timelineID=000026 |website = ProCon.org |access-date = 27 July 2017 |archive-date = 15 July 2017 |archive-url = https://web.archive.org/web/20170715175551/http://medicalmarijuana.procon.org/view.timeline.php?timelineID=000026 |url-status = live }}</ref>  In 2001, {{wipe|Canada}} became the first country to adopt a system regulating the medical use of cannabis.<ref>{{cite news |title = Marijuana's journey to legal health treatment: the Canadian experience |url = http://www.cbc.ca/news/health/marijuana-s-journey-to-legal-health-treatment-the-canadian-experience-1.799488 |access-date = 27 July 2017 |work = CBC News |date = 17 August 2009 |archive-date = 14 June 2017 |archive-url = https://web.archive.org/web/20170614170017/http://www.cbc.ca/news/health/marijuana-s-journey-to-legal-health-treatment-the-canadian-experience-1.799488 |url-status = live }}</ref>

<gallery class="center" caption="" widths="200px" heights="150px">
File:Da-ma.png|The use of cannabis, at least as fiber, has been shown to go back at least 10,000 years in Taiwan. "Dà má" ([[Pinyin]] pronunciation) is the Chinese expression for cannabis, the first character meaning "big" and the second character meaning "hemp".
File:Drug bottle containing cannabis.jpg|''Cannabis indica'' fluid extract, American Druggists Syndicate, pre-1937
File:CannabisAmericana JLHopkins B.jpg|An advertisement for ''cannabis americana'' distributed by a pharmacist in New York in 1917
File:PEbers c41-bc.jpg|The [[Chemistry:Ebers Papyrus|Ebers Papyrus]] ({{circa|1550 BCE}}) from Ancient Egypt has a prescription for medical marijuana applied directly for inflammation.
</gallery>

== Society and culture ==

=== Legal status ===

[[File:Map-of-world-medical-cannabis-laws.svg|thumb|right|380px|alt=Map of world medical cannabis laws|
'''Legal status of (whole-plant) medical cannabis worldwide'''
----
{{legend|#0ea817|Legal as authorized by a physician}}
{{legend|#0d00f2|Legal for any use (no prescription required)}}
----
<small>See also [[:File:Map-of-world-cannabis-laws.svg|countries that have decriminalized or where enforcement is limited]].</small>
]]

Countries that have legalized the medical use of cannabis include {{wipe|Argentina}},<ref>{{cite news |last1=Politi |first1=Daniel |title=Argentina to Allow Medicinal Marijuana to Be Grown at Home |url=https://www.nytimes.com/2020/11/12/world/americas/argentina-cannabis-marijuana.html |access-date=22 January 2023 |work=The New York Times |date=12 November 2020 |archive-date=23 January 2023 |archive-url=https://web.archive.org/web/20230123041514/https://www.nytimes.com/2020/11/12/world/americas/argentina-cannabis-marijuana.html |url-status=live }}</ref> {{wipe|Australia}},<ref>{{cite news |last1=Jolly |first1=William |title=Medicinal Marijuana Legal In Australia |url=https://www.canstar.com.au/health-insurance/victoria-legalises-medicinal-marijuana/ |access-date=16 July 2018 |work=Canstar |date=28 February 2018 |archive-date=17 July 2018 |archive-url=https://web.archive.org/web/20180717013204/https://www.canstar.com.au/health-insurance/victoria-legalises-medicinal-marijuana/ |url-status=live }}</ref> {{wipe|Brazil}},<ref>{{cite news |last1=Ponieman |first1=Natan |title=Brazil Regulates Sale Of Medical Marijuana Products |url=https://www.benzinga.com/markets/cannabis/19/12/14924387/brazil-regulates-sale-of-medical-marijuana-products |access-date=10 December 2019 |work=Benzinga |date=3 December 2019 |archive-date=14 March 2021 |archive-url=https://web.archive.org/web/20210314045550/https://www.benzinga.com/markets/cannabis/19/12/14924387/brazil-regulates-sale-of-medical-marijuana-products |url-status=live }}</ref> {{wipe|Canada}},<ref name="Motley">{{cite news|last1=Williams|first1=Sean|title=10 Countries (Aside From the U.S.) Where Some Form of Medical Marijuana Is Legal|url=https://www.fool.com/investing/general/2016/05/15/10-countries-aside-from-the-us-where-some-form-of.aspx|access-date=5 November 2017|work=The Motley Fool|date=15 May 2016|archive-date=11 November 2017|archive-url=https://web.archive.org/web/20171111152109/https://www.fool.com/investing/general/2016/05/15/10-countries-aside-from-the-us-where-some-form-of.aspx|url-status=live}}</ref> {{wipe|Chile}},<ref name="Motley" /> Colombia,<ref name="Motley" /> Costa Rica,<ref>{{cite news |title=Costa Rica legalizes medicinal marijuana use, hemp growing |url=https://apnews.com/article/health-caribbean-marijuana-recreational-marijuana-costa-rica-7fc0e4e7b8881613210164f6acf6d9e8 |access-date=22 January 2023 |work=Associated Press |date=2 March 2022 |archive-date=7 March 2022 |archive-url=https://web.archive.org/web/20220307050530/https://apnews.com/article/health-caribbean-marijuana-recreational-marijuana-costa-rica-7fc0e4e7b8881613210164f6acf6d9e8 |url-status=live }}</ref> Croatia,<ref>{{cite news|last1=Veselica|first1=Lajla|title=Croatia legalises marijuana for medical use|url=https://www.yahoo.com/news/croatia-allows-marijuana-medical-114920214.html|access-date=4 November 2017|work=Yahoo News|agency=AFP|date=15 October 2015|archive-date=14 March 2021|archive-url=https://web.archive.org/web/20210314045549/https://www.yahoo.com/news/croatia-allows-marijuana-medical-114920214.html|url-status=dead}}</ref> [[Place:Cyprus|Cyprus]],<ref>{{cite news |title=Cyprus begins to distribute medical cannabis |url=http://in-cyprus.com/cyprus-begins-to-distribute-medical-cannabis |access-date=11 November 2017 |work=InCyprus |date=22 May 2017 |archive-url=https://web.archive.org/web/20170609034857/http://in-cyprus.com/cyprus-begins-to-distribute-medical-cannabis |archive-date=9 June 2017}}</ref> [[Place:Czech Republic|Czech Republic]],<ref name="Motley" /> {{wipe|Finland}},<ref>{{cite web |title= Legal status of cannabis in Finland – An overview |url= https://sensiseeds.com/en/blog/legal-status-cannabis-finland-overview |website= Sensi Seeds |access-date= 4 November 2017 |archive-date= 14 March 2021 |archive-url= https://web.archive.org/web/20210314045550/https://sensiseeds.com/en/blog/countries/cannabis-in-finland-laws-use-history/ |url-status= live }}</ref> {{wipe|Germany}},<ref>{{cite news |last1= Senthilingam |first1= Meera |title= Germany joins the global experiment on marijuana legalization |work= CNN.com |url= http://www.cnn.com/2016/12/29/health/global-marijuana-cannabis-laws/index.html |access-date= 4 November 2017 |date= 6 March 2017 |archive-date= 14 March 2021 |archive-url= https://web.archive.org/web/20210314045553/https://www.cnn.com/2016/12/29/health/global-marijuana-cannabis-laws/index.html |url-status= live }}</ref> Greece,<ref>{{cite news |last1= Revesz |first1=Rachael |title=Greece legalises marijuana for medical purposes |url= https://www.independent.co.uk/news/world/europe/greece-marijuana-legal-medical-cannabis-weed-law-passes-a7821771.html |archive-url=https://ghostarchive.org/archive/20220512/https://www.independent.co.uk/news/world/europe/greece-marijuana-legal-medical-cannabis-weed-law-passes-a7821771.html |archive-date=12 May 2022 |url-access=subscription |url-status=live |access-date=4 November 2017 |work= The Independent |date=3 July 2017}}</ref> [[Place:Israel|Israel]],<ref>{{cite news |last1=Schwartz |first1=Yardena |title=How the Booming Israeli Weed Industry Is Changing American Pot |work=Rollingstone.com |url=https://www.rollingstone.com/culture/features/how-booming-israeli-weed-industry-is-changing-american-pot-w499117 |access-date=4 November 2017 |date=24 August 2017 |archive-date=4 November 2017 |archive-url=https://web.archive.org/web/20171104043420/http://www.rollingstone.com/culture/features/how-booming-israeli-weed-industry-is-changing-american-pot-w499117 |url-status=live }}</ref> Italy,<ref>{{cite news |last=Samuels |first=Gabriel |title= Italian army aims to produce "the best-quality" medical marijuana after finding current batches deficient |url= https://www.independent.co.uk/news/world/europe/cannabis-italy-army-medical-marijuana-italian-military-produces-best-quality-weed-a7156176.html |archive-url=https://ghostarchive.org/archive/20220512/https://www.independent.co.uk/news/world/europe/cannabis-italy-army-medical-marijuana-italian-military-produces-best-quality-weed-a7156176.html |archive-date=12 May 2022 |url-access=subscription |url-status=live |access-date=4 November 2017 |work=The Independent |date=26 July 2016}}</ref> Jamaica,<ref>{{cite news |last1=Bud |first1=Monterey |title=Jamaica's Kaya Farms Becomes First Medical Marijuana Dispensary To Open |url=https://www.marijuana.com/news/2018/03/jamaicas-kaya-farms-becomes-first-medical-marijuana-dispensary-to-open |access-date=16 July 2018 |work=marijuana.com |date=19 March 2018 |archive-date=14 March 2021 |archive-url=https://web.archive.org/web/20210314045550/https://weedmaps.com/news/ |url-status=live }}</ref> [[Place:Lebanon|Lebanon]],<ref>{{cite news |url=https://www.nytimes.com/reuters/2020/04/21/world/middleeast/21reuters-lebanon-crisis-cannabis.html |title=Lebanon Legalizes Cannabis Farming for Medicinal Use |work=The New York Times |agency=Reuters |date=21 April 2020 |access-date=25 April 2020 |archive-date=23 April 2020 |archive-url=https://web.archive.org/web/20200423112646/https://www.nytimes.com/reuters/2020/04/21/world/middleeast/21reuters-lebanon-crisis-cannabis.html |url-status=live }}</ref> Luxembourg,<ref>{{cite news |last1= Pritchard |first1= Heledd |title= Cannabis for medical use legalised in Luxembourg |url= https://luxtimes.lu/luxembourg/34274-cannabis-for-medical-use-legalised-in-luxembourg |access-date= 8 July 2018 |work= Luxembourg Times |date= 29 June 2018 |archive-date= 29 June 2018 |archive-url= https://web.archive.org/web/20180629104554/https://luxtimes.lu/luxembourg/34274-cannabis-for-medical-use-legalised-in-luxembourg |url-status= live }}</ref> Malta,<ref>{{cite news |last1=Pace |first1=Maria |title=Malta has officially legalised medical cannabis |url=https://www.maltatoday.com.mt/news/national/85616/malta_has_officially_legalised_medical_cannabis |access-date=24 August 2018 |work=Malta Today |date=27 March 2018 |archive-date=1 July 2021 |archive-url=https://web.archive.org/web/20210701160703/https://www.maltatoday.com.mt/news/national/85616/malta_has_officially_legalised_medical_cannabis |url-status=live }}</ref> Morocco,<ref>{{cite news |title=Morocco: Bill to legalise cannabis enters into force |url=https://www.middleeastmonitor.com/20210731-morocco-bill-to-legalise-cannabis-enters-into-force/ |access-date=22 January 2023 |work=Middle East Monitor |date=31 July 2021 |archive-date=11 August 2021 |archive-url=https://web.archive.org/web/20210811195407/https://www.middleeastmonitor.com/20210731-morocco-bill-to-legalise-cannabis-enters-into-force/ |url-status=live }}</ref> the Netherlands,<ref name="Motley" /> [[Earth:New Zealand|New Zealand]],<ref>{{cite news |last1=Ainge Roy |first1=Eleanor |title=New Zealand passes laws to make medical marijuana widely available |url=https://www.theguardian.com/world/2018/dec/11/new-zealand-passes-laws-to-make-medical-marijuana-widely-available |access-date=20 January 2019 |work=The Guardian |date=11 December 2018 |archive-date=13 January 2019 |archive-url=https://web.archive.org/web/20190113005629/https://www.theguardian.com/world/2018/dec/11/new-zealand-passes-laws-to-make-medical-marijuana-widely-available |url-status=live }}</ref> North Macedonia,<ref>{{cite news |last1=Marusic |first1=Sinisa Jakov |title=Macedonia Allows Medical Marijuana in Pharmacies |url=http://www.balkaninsight.com/en/article/macedonia-allows-medical-marijuana-in-pharmacies-05-31-2016 |access-date=4 November 2017 |work=Balkan Insight |date=1 June 2016 |archive-date=31 October 2017 |archive-url=https://web.archive.org/web/20171031051345/http://www.balkaninsight.com/en/article/macedonia-allows-medical-marijuana-in-pharmacies-05-31-2016 |url-status=live }}</ref> Panama,<ref>{{cite news |title=El gobierno de Panamá legalizó el uso medicinal y terapéutico del cannabis |url=https://www.infobae.com/america/america-latina/2021/10/14/el-gobierno-de-panama-legalizo-el-uso-medicinal-y-terapeutico-del-cannabis/ |access-date=22 January 2023 |work=Infobae |date=14 October 2021 |archive-date=17 October 2021 |archive-url=https://web.archive.org/web/20211017212957/https://www.infobae.com/america/america-latina/2021/10/14/el-gobierno-de-panama-legalizo-el-uso-medicinal-y-terapeutico-del-cannabis/ |url-status=live }}</ref> Peru,<ref>{{cite news |last1=Collyns |first1=Dan |title=Peru legalises medical marijuana in move spurred by mother's home lab |url=https://www.theguardian.com/world/2017/oct/20/peru-marijuana-cannabis-legal-terminally-ill-children |access-date=4 Nov 2017 |work=The Guardian |date=20 October 2017 |archive-date=3 July 2018 |archive-url=https://web.archive.org/web/20180703075436/https://www.theguardian.com/world/2017/oct/20/peru-marijuana-cannabis-legal-terminally-ill-children |url-status=live }}</ref> {{wipe|Poland}},<ref>{{cite news |title=Medical use of cannabis officially legal in Poland |url=http://www.thenews.pl/1/9/Artykul/333153,Medical-use-of-cannabis-officially-legal-in-Poland |access-date=4 November 2017 |work=Radio Poland |agency=PAP |date=11 February 2017 |archive-date=14 March 2021 |archive-url=https://web.archive.org/web/20210314045554/https://connect.facebook.net/en_US/fbds.js |url-status=dead }}</ref> Portugal,<ref>{{cite news |last1=Lamers |first1=Matt |title=Portugal passes medical cannabis law, opens domestic market |url=https://mjbizdaily.com/portugal-passes-medical-cannabis-law-opens-domestic-market/ |access-date=24 August 2018 |work=Marijuana Business Daily |date=21 June 2018 |archive-date=5 September 2019 |archive-url=https://web.archive.org/web/20190905191222/https://mjbizdaily.com/portugal-passes-medical-cannabis-law-opens-domestic-market/ |url-status=live }}</ref> [[Biology:Rwanda|Rwanda]],<ref>{{cite news |last1=Mwai |first1=Collins |title=10 things to know after Rwanda gives the green light for medical marijuana |url=https://www.newtimes.co.rw/article/187172/News/10-things-to-know-after-rwanda-gives-the-green-light-for-medical-marijuana |access-date=22 January 2023 |work=The New Times |date=29 June 2021 |archive-date=23 January 2023 |archive-url=https://web.archive.org/web/20230123022218/https://www.newtimes.co.rw/article/187172/News/10-things-to-know-after-rwanda-gives-the-green-light-for-medical-marijuana |url-status=live }}</ref> {{wipe|Spain}},<ref>{{cite news |last1=King |first1=Chris |title=Congress approves the legalisation of medical cannabis in Spain |url=https://euroweeklynews.com/2022/06/28/congress-approves-the-legalisation-of-medical-cannabis-in-spain/ |access-date=22 January 2023 |work=EuroWeekly News |date=28 June 2022 |archive-date=5 December 2022 |archive-url=https://web.archive.org/web/20221205014810/https://euroweeklynews.com/2022/06/28/congress-approves-the-legalisation-of-medical-cannabis-in-spain/ |url-status=live }}</ref> Sri Lanka,<ref>{{citation |title=South Asia Regional Profile |url=https://www.unodc.org/pdf/india/publications/south_Asia_Regional_Profile_Sept_2005/13_srilanka.pdf |access-date=2 February 2019 |publisher=United Nations Office on Drugs and Crime |date=15 September 2005 |archive-date=23 September 2020 |archive-url=https://web.archive.org/web/20200923171657/https://www.unodc.org/pdf/india/publications/south_Asia_Regional_Profile_Sept_2005/13_srilanka.pdf |url-status=live }}</ref> {{wipe|Switzerland}},<ref>{{cite news |title=Switzerland to legalise medicinal cannabis from Monday |url=https://www.thelocal.ch/20220728/switzerland-to-legalise-medicinal-cannabis-from-monday |access-date=22 January 2023 |work=The Local |date=28 July 2022 |archive-url=https://web.archive.org/web/20220809105423/https://www.thelocal.ch/20220728/switzerland-to-legalise-medicinal-cannabis-from-monday/ |archive-date=9 August 2022}}</ref> Thailand,<ref>{{cite news |last1=Mosbergen |first1=Dominique |title=Thailand Approves Medical Marijuana In Regional First |url=https://www.huffingtonpost.com/entry/thailand-medical-marijuana_us_5c22e6aae4b0407e907e7c18 |access-date=20 January 2019 |work=HuffPost |date=25 December 2018 |archive-date=19 January 2019 |archive-url=https://web.archive.org/web/20190119155356/https://www.huffingtonpost.com/entry/thailand-medical-marijuana_us_5c22e6aae4b0407e907e7c18 |url-status=live }}</ref> the {{wipe|United Kingdom}},<ref>{{cite news |title=Medicinal cannabis products to be legalised |url=https://www.bbc.co.uk/news/health-44968386 |access-date=28 July 2018 |work=BBC |date=26 July 2018 |archive-date=28 July 2018 |archive-url=https://web.archive.org/web/20180728045627/https://www.bbc.co.uk/news/health-44968386 |url-status=live }}</ref> and Uruguay.<ref name="Motley" />  Other countries have more restrictive laws that allow only the use of isolated cannabinoid drugs such as Sativex or Epidiolex.<ref>{{cite web |title=Sativex (delta-9-tetrahydrocannabinol and cannabidiol) |url= https://www.gwpharm.com/products-pipeline/sativex-delta-9-tetrahydrocannabinol-and-cannabidiol |website=GW Pharmaceuticals |access-date=5 November 2017 |archive-url=https://web.archive.org/web/20171210062733/https://www.gwpharm.com/products-pipeline/sativex-delta-9-tetrahydrocannabinol-and-cannabidiol |archive-date=10 December 2017}}</ref><ref>{{citation |title=Medical use of cannabis and cannabinoids |url=http://www.emcdda.europa.eu/system/files/publications/10171/20185584_TD0618186ENN_PDF.pdf |publisher=European Monitoring Centre for Drugs and Drug Addiction |date=December 2018 |access-date=11 December 2019 |archive-date=28 June 2021 |archive-url=https://web.archive.org/web/20210628171058/https://www.emcdda.europa.eu/system/files/publications/10171/20185584_TD0618186ENN_PDF.pdf |url-status=live }}</ref>  Countries with the most relaxed policies include Canada,<ref>{{cite news |last=Sapra |first=Bani |title=Canada becomes second nation in the world to legalize marijuana |url=https://www.cnn.com/2018/06/20/health/canada-legalizes-marijuana/index.html |access-date=3 July 2018 |work=CNN |date=20 June 2018 |archive-date=12 February 2019 |archive-url=https://web.archive.org/web/20190212125138/https://www.cnn.com/2018/06/20/health/canada-legalizes-marijuana/index.html |url-status=live }}</ref> the Netherlands,<ref name="Motley" /> Thailand,<ref>{{cite news |last1=Ives |first1=Mike |title=Weed Is Now Legal in Thailand. How Long Will the High Times Last? |url=https://www.nytimes.com/2022/11/10/world/asia/thailand-weed-cannabis-law.html |access-date=22 January 2023 |work=The New York Times |date=10 November 2022 |archive-url=https://web.archive.org/web/20221127104321/https://www.nytimes.com/2022/11/10/world/asia/thailand-weed-cannabis-law.html |archive-date=27 November 2022}}</ref> and Uruguay,<ref name="Motley" /> where cannabis can be purchased without need for a prescription.  In Mexico, THC content of medical cannabis is limited to one percent.<ref>{{cite news |last1= Janikian |first1= Michelle |title= Legal Pot In Mexico: Everything You Need to Know |url= https://www.rollingstone.com/culture/features/legal-pot-in-mexico-everything-you-need-to-know-w503038 |access-date= 5 November 2017 |magazine= Rolling Stone |date= 14 September 2017 |archive-date= 11 November 2017 |archive-url= https://web.archive.org/web/20171111151947/http://www.rollingstone.com/culture/features/legal-pot-in-mexico-everything-you-need-to-know-w503038 |url-status= live }}</ref>  In the {{wipe|United States}}, the legality of medical cannabis varies by state.<ref name="NCSL" />

Cannabis and its derivatives are subject to regulation under three {{wipe|United Nations}} treaties: the 1961 [[Medicine:Single Convention on Narcotic Drugs|Single Convention on Narcotic Drugs]], the 1971 [[Medicine:Convention on Psychotropic Substances|Convention on Psychotropic Substances]], and the 1988 Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.<ref>{{cite journal |last1=Habibi |first1=Roojin |last2=Hoffman |first2=Steven J. |title=Legalizing Cannabis Violates the UN Drug Control Treaties, But Progressive Countries Like Canada Have Options |journal=Ottawa Law Review |date=March 2018 |volume=49 |issue=2 |url=https://www.researchgate.net/publication/323697447 |access-date=8 January 2021 |archive-date=28 August 2021 |archive-url=https://web.archive.org/web/20210828161532/https://www.researchgate.net/publication/323697447_Legalizing_Cannabis_Violates_the_UN_Drug_Control_Treaties_But_Progressive_Countries_Like_Canada_Have_Options |url-status=live }}</ref> Cannabis is classified as a Schedule I drug under the Single Convention treaty, meaning that medical use is allowed but that it is considered to be an addictive drug with a serious risk of abuse – along with other drugs such as opium and cocaine.<ref>{{cite web |title=Classification of controlled drugs |url=https://www.emcdda.europa.eu/publications/topic-overviews/classification-of-controlled-drugs/html_en |website=European Monitoring Centre for Drugs and Drug Addiction |access-date=7 January 2021 |archive-date=8 January 2021 |archive-url=https://web.archive.org/web/20210108164743/https://www.emcdda.europa.eu/publications/topic-overviews/classification-of-controlled-drugs/html_en |url-status=live }}</ref> Prior to December 2020 it was also included in Schedule IV, a subset of Schedule I, which is for only the most dangerous drugs such as heroin and fentanyl.<ref>{{cite news |last1=Kaur |first1=Harmeet |title=The UN removes cannabis from a list of the most dangerous substances |url=https://www.cnn.com/2020/12/02/health/un-reclassifies-cannabis-scn-trnd/index.html |access-date=7 January 2021 |work=CNN |date=2 December 2020 |archive-date=12 December 2020 |archive-url=https://web.archive.org/web/20201212164024/https://www.cnn.com/2020/12/02/health/un-reclassifies-cannabis-scn-trnd/index.html |url-status=live }}</ref> Member nations of the UN Commission on Narcotic Drugs voted 27–25 to remove it from Schedule IV on 2 December 2020,<ref>{{cite news |last1=Kwai |first1=Isabella |title=U.N. Reclassifies Cannabis as a Less Dangerous Drug |url=https://www.nytimes.com/2020/12/02/world/europe/cannabis-united-nations-drug-policy.html |access-date=7 January 2021 |work=The New York Times |date=2 December 2020 |archive-date=10 January 2021 |archive-url=https://web.archive.org/web/20210110040927/https://www.nytimes.com/2020/12/02/world/europe/cannabis-united-nations-drug-policy.html |url-status=live }}</ref> following a [[Organization:World Health Organization|World Health Organization]] recommendation for removal in January 2019.<ref>{{cite news |title=WHO recommends rescheduling of cannabis |url=https://www.emcdda.europa.eu/news/2019/who-recommends-rescheduling-of-cannabis_en |access-date=7 January 2021 |work=European Monitoring Centre for Drugs and Drug Addiction |date=25 March 2019 |archive-date=28 December 2020 |archive-url=https://web.archive.org/web/20201228094221/https://www.emcdda.europa.eu/news/2019/who-recommends-rescheduling-of-cannabis_en |url-status=live }}</ref><ref>{{cite news |last1=Georgiou |first1=Aristos |title=WHO Recommends Rescheduling Cannabis in International Law for First Time in History |url=https://www.newsweek.com/who-recommends-rescheduling-cannabis-international-law-first-time-history-1324613 |access-date=7 January 2021 |work=Newsweek |date=8 February 2019 |archive-date=20 December 2020 |archive-url=https://web.archive.org/web/20201220172821/https://www.newsweek.com/who-recommends-rescheduling-cannabis-international-law-first-time-history-1324613 |url-status=live }}</ref>

==== United States ====

In the United States, the use of cannabis for medical purposes is legal in 38 states, four out of five permanently inhabited U.S. territories, and the [[Place:Washington, D.C.|District of Columbia]].<ref name="NCSL">{{cite web |title = State Medical Marijuana Laws |url = http://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx |website = National Conference of State Legislatures |date = 12 September 2022 |access-date = 6 October 2022 |archive-date = 11 December 2018 |archive-url = https://web.archive.org/web/20181211125951/http://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx |url-status = live }}</ref>  An additional 10 states have more restrictive laws allowing the use of low-THC products.<ref name="NCSL" />  Cannabis remains illegal at the federal level under the Controlled Substances Act, which classifies it as a Schedule I drug with a high potential for abuse and no accepted medical use.  In December 2014, however, the Rohrabacher–Farr amendment was signed into law, prohibiting the Justice Department from prosecuting individuals acting in accordance with state medical cannabis laws.<ref>{{cite news |last1 = Ingraham |first1 = Christopher |title = Jeff Sessions personally asked Congress to let him prosecute medical-marijuana providers |url = https://www.washingtonpost.com/news/wonk/wp/2017/06/13/jeff-sessions-personally-asked-congress-to-let-him-prosecute-medical-marijuana-providers/ |access-date = 9 July 2017 |newspaper = The Washington Post |date = 13 June 2017 |archive-date = 4 July 2017 |archive-url = https://web.archive.org/web/20170704095547/https://www.washingtonpost.com/news/wonk/wp/2017/06/13/jeff-sessions-personally-asked-congress-to-let-him-prosecute-medical-marijuana-providers/ |url-status = live }}</ref>

=== Economics ===

==== Distribution ====
[[File:Discount Medical Marijuana - 2.jpg|thumb|right|Medical marijuana dispensary in Denver, Colorado ]]

The method of obtaining medical cannabis varies by region and by legislation. In the US, most consumers grow their own or buy it from cannabis dispensaries in states where it is legal.<ref name=Borgelt2013 /><ref name=BaltSun>{{cite news |url = http://www.baltimoresun.com/news/maryland/sun-investigates/bs-md-medical-marijuana-fees-20141011,0,3253557.story?page=1 |title = Medical marijuana fees stir debate in Maryland |newspaper = The Baltimore Sun |author = Timothy B. Wheeler |date = 11 October 2014 |access-date = 12 October 2014 |archive-date = 16 October 2014 |archive-url = https://web.archive.org/web/20141016223445/http://www.baltimoresun.com/news/maryland/sun-investigates/bs-md-medical-marijuana-fees-20141011,0,3253557.story?page=1 |url-status = dead }}</ref> Marijuana vending machines for selling or dispensing cannabis are in use in the United States and are planned to be used in Canada.<ref name=FirstForeignMarket>{{cite news |url = http://news.nationalpost.com/2013/10/16/pot-vending-machines-to-start-rolling-into-canada-after-firm-partners-with-u-s-company/ |title = The pot vending machine's first foreign market? Canada, of course, "a seed for the rest of the world" |newspaper = National Post |author = Blackwell, Tom |date = 16 October 2013 |access-date = 4 December 2013 }}</ref> In 2014, the startup Meadow began offering on-demand delivery of medical marijuana in the San Francisco Bay Area, through their mobile app.<ref>{{cite web |url = https://techcrunch.com/2014/10/14/uber-for-weed-startup-meadow-lights-up-in-san-francisco/ |title = Uber-For-Weed Startup Meadow Lights Up In San Francisco |date = 14 October 2014 |publisher = AOL |work = TechCrunch |access-date = 22 January 2016 |archive-date = 23 January 2016 |archive-url = https://web.archive.org/web/20160123174609/http://techcrunch.com/2014/10/14/uber-for-weed-startup-meadow-lights-up-in-san-francisco/ |url-status = live }}</ref>

Almost 70% of medical cannabis is exported from the United Kingdom, according to a 2017 United Nations report, with much of the remaining amount coming from Canada and the Netherlands.<ref>{{Cite web|date=2018-03-07|title=The UK is the world's largest producer of legal Cannabis, UN body finds|url=https://www.independent.co.uk/news/uk/home-news/cannabis-legal-uk-worlds-largest-producer-marijuana-weed-un-body-findings-a8243921.html |archive-url=https://ghostarchive.org/archive/20220512/https://www.independent.co.uk/news/uk/home-news/cannabis-legal-uk-worlds-largest-producer-marijuana-weed-un-body-findings-a8243921.html |archive-date=12 May 2022 |url-access=subscription |url-status=live|access-date=2020-12-07|website=The Independent|language=en}}</ref>

==== Insurance ====
In the United States, health insurance companies may not pay for a medical marijuana prescription as the [[Organization:Food and Drug Administration|Food and Drug Administration]] must approve any substance for medicinal purposes. Before this can happen, the FDA must first permit the study of the medical benefits and drawbacks of the substance, which it has not done since it was placed on Schedule I of the Controlled Substances Act in 1970. Therefore, all expenses incurred fulfilling a medical marijuana prescription will possibly be incurred as out-of-pocket.<ref>{{cite web |url = http://www.insurancecompliancecorner.com/the-medical-marijuana-debate/ |title = The Medical Marijuana Debate |last1 = Clark |first1 = Tonya Body |date = 10 February 2015 |website = Compliance Corner |publisher = Wolters Kluwer Financial Services |access-date = 26 February 2015 |archive-date = 26 February 2015 |archive-url = https://web.archive.org/web/20150226193755/http://www.insurancecompliancecorner.com/the-medical-marijuana-debate/ |url-status = dead }}</ref>  However, the New Mexico Court of Appeals has ruled that [[Workers' compensation|workers' compensation]] insurance must pay for prescribed marijuana as part of the state's Medical Cannabis Program.<ref>{{cite web |url = http://nmpoliticalreport.com/4483/court-employer-cant-block-workers-comp-for-medical-marijuana/ |title = Court: Employer can't block workers' comp for medical marijuana |last1 = Peters |first1 = Joey |date = 29 June 2015 |website = NM Political Report |access-date = 30 June 2015 |archive-date = 30 June 2015 |archive-url = https://web.archive.org/web/20150630061942/http://nmpoliticalreport.com/4483/court-employer-cant-block-workers-comp-for-medical-marijuana/ |url-status = live }}</ref>

=== Positions of medical organizations ===
Medical organizations that have issued statements in support of allowing access to medical cannabis include the American Nurses Association,<ref name="ANA">{{citation |title = Therapeutic Use of Marijuana and Related Cannabinoids |url = https://www.nursingworld.org/~4ad4a8/globalassets/docs/ana/therapeutic-use-of-marijuana-and-related-cannabinoids.pdf |publisher = American Nurses Association |date = 2016 |access-date = 13 May 2018 |archive-date = 21 September 2020 |archive-url = https://web.archive.org/web/20200921162957/https://www.nursingworld.org/~4ad4a8/globalassets/docs/ana/therapeutic-use-of-marijuana-and-related-cannabinoids.pdf |url-status = live }}</ref> [[Organization:American Public Health Association|American Public Health Association]],<ref>{{cite web |title = Resolution on Medical Marijuana |url = http://druglibrary.org/schaffer/hemp/medical/apha.htm |website = druglibrary.org |access-date = 30 July 2017 |archive-date = 19 October 2017 |archive-url = https://web.archive.org/web/20171019170836/http://druglibrary.org/schaffer/hemp/medical/apha.htm |url-status = live }}</ref> American Medical Student Association,<ref>{{cite web |title = House of Delegates 2017, Resolution: A8 |url = http://www.amsa.org/wp-content/uploads/2015/05/A8-Principles-Regarding-Illegal-drugs-alcohol-and-tobacco-1.pdf |website = amsa.org |publisher = American Medical Student Association |access-date = 30 July 2017 |archive-date = 1 August 2017 |archive-url = https://web.archive.org/web/20170801124633/http://www.amsa.org/wp-content/uploads/2015/05/A8-Principles-Regarding-Illegal-drugs-alcohol-and-tobacco-1.pdf |url-status = live }}</ref> National Multiple Sclerosis Society,<ref>{{cite web |title = Medical Marijuana (Cannabis) FAQs |url = http://www.nationalmssociety.org/Treating-MS/Complementary-Alternative-Medicines/Marijuana/Marijuana-FAQs |website = National Multiple Sclerosis Society |access-date = 30 July 2017 |archive-date = 31 July 2017 |archive-url = https://web.archive.org/web/20170731163441/http://www.nationalmssociety.org/Treating-MS/Complementary-Alternative-Medicines/Marijuana/Marijuana-FAQs |url-status = live }}</ref> Epilepsy Foundation,<ref>{{cite press release |last1 = Gattone |first1 = Philip M. |last2 = Lammert |first2 = Warreb |name-list-style = vanc |title = Epilepsy Foundation Calls for Increased Medical Marijuana Access and Research |url = http://www.epilepsy.com/article/2014/2/epilepsy-foundation-calls-increased-medical-marijuana-access-and-research |access-date = 30 July 2017 |location = Washington, D.C. |publisher = Epilepsy Foundation |date = 20 February 2014 |archive-date = 31 July 2017 |archive-url = https://web.archive.org/web/20170731185604/http://www.epilepsy.com/article/2014/2/epilepsy-foundation-calls-increased-medical-marijuana-access-and-research |url-status = live }}</ref> and Leukemia & Lymphoma Society.<ref>{{cite web |title = Medical Marijuana Use and Research |url = https://www.maps.org/research-archive/mmj/lnls-res.pdf |website = maps.org |publisher = Leukemia & Lymphoma Society |access-date = 30 July 2017 |archive-date = 19 October 2017 |archive-url = https://web.archive.org/web/20171019171337/https://www.maps.org/research-archive/mmj/lnls-res.pdf |url-status = live }}</ref>

Organizations that oppose the legalization of medical cannabis include the American Academy of Pediatrics<ref name="AAP">{{citation |title = American Academy of Pediatrics Reaffirms Opposition to Legalizing Marijuana for Recreational or Medical Use |url = https://www.aap.org/en-us/about-the-aap/aap-press-room/Pages/American-Academy-of-Pediatrics-Reaffirms-Opposition-to-Legalizing-Marijuana-for-Recreational-or-Medical-Use.aspx |access-date = 30 July 2017 |publisher = American Academy of Pediatrics |date = 26 January 2015 |archive-date = 26 April 2018 |archive-url = https://web.archive.org/web/20180426075849/https://www.aap.org/en-us/about-the-aap/aap-press-room/pages/American-Academy-of-Pediatrics-Reaffirms-Opposition-to-Legalizing-Marijuana-for-Recreational-or-Medical-Use.aspx |url-status = dead }}</ref> and American Psychiatric Association.<ref>{{cite web |title = Position Statement on Marijuana as Medicine |url = https://www.psychiatry.org/file%20library/about-apa/organization-documents-policies/policies/position-2013-marijuana-as-medicine.pdf |website = American Psychiatric Association |access-date = 30 July 2017 |archive-date = 31 July 2017 |archive-url = https://web.archive.org/web/20170731152505/https://www.psychiatry.org/file%20library/about-apa/organization-documents-policies/policies/position-2013-marijuana-as-medicine.pdf |url-status = dead }}</ref>  However, the AAP also supports rescheduling for the purpose of facilitating research.<ref name="AAP" />

The American Medical Association<ref>{{citation |title = Use of Cannabis for Medicinal Purposes |url = https://www.ama-assn.org/sites/default/files/media-browser/public/about-ama/councils/Council%20Reports/council-on-science-public-health/i09-csaph-medical-marijuana.pdf |publisher = American Medical Association |date = 2009 |access-date = 1 July 2017 |archive-date = 19 October 2017 |archive-url = https://web.archive.org/web/20171019170230/https://www.ama-assn.org/sites/default/files/media-browser/public/about-ama/councils/Council%20Reports/council-on-science-public-health/i09-csaph-medical-marijuana.pdf |url-status = dead }}</ref> and American College of Physicians<ref>{{citation |title = Supporting Research into the Therapeutic Role of Marijuana |url = https://www.acponline.org/acp_policy/policies/supporting_research_therapeutic_role_of_marijuana_2016.pdf |publisher = American College of Physicians |date = February 2016 |access-date = 1 August 2017 |archive-date = 3 August 2020 |archive-url = https://web.archive.org/web/20200803220748/https://www.acponline.org/acp_policy/policies/supporting_research_therapeutic_role_of_marijuana_2016.pdf |url-status = live }}</ref> do not take a position on the legalization of medical cannabis, but have called for the Schedule I classification to be reviewed. The American Academy of Family Physicians<ref name="AAFP">{{cite news |title=AAFP Releases Marijuana, Cannabinoids Position Paper |url=https://www.aafp.org/news/health-of-the-public/20190920cannabispaper.html |access-date=6 October 2019 |work=American Academy of Family Physicians |date=20 September 2019 |archive-date=28 September 2019 |archive-url=https://web.archive.org/web/20190928025405/https://www.aafp.org/news/health-of-the-public/20190920cannabispaper.html |url-status=live }}</ref> and American Society of Addiction Medicine<ref>{{cite press release |date=13 October 2020 |title=ASAM Issues New Public Policy Statement on Cannabis |url=https://www.asam.org/Quality-Science/publications/magazine/read/asam-advocacy-blog/2020/10/13/asam-issues-new-public-policy-statement-on-cannabis |location=Rockville, MD |publisher=American Society of Addiction Medicine |access-date=1 November 2020 |archive-date=8 November 2020 |archive-url=https://web.archive.org/web/20201108221433/https://www.asam.org/Quality-Science/publications/magazine/read/asam-advocacy-blog/2020/10/13/asam-issues-new-public-policy-statement-on-cannabis |url-status=dead }}</ref> also do not take a position, but do support rescheduling to better facilitate research.  The [[Organization:American Heart Association|American Heart Association]] says that "many of the concerning health implications of cannabis include cardiovascular diseases" but that it supports rescheduling to allow "more nuanced ... marijuana legislation and regulation" and to "reflect the existing science behind cannabis".<ref>{{cite journal |author=American Heart Association |title=Medical Marijuana, Recreational Cannabis, and Cardiovascular Health |journal=Circulation |date=5 August 2020 |volume=142 |issue=10 |pages=e131–52 |doi=10.1161/CIR.0000000000000883 |pmid=32752884 |doi-access=free }}</ref>  The American Cancer Society<ref name="ACS">{{cite web |title = Marijuana and Cancer |url = https://www.cancer.org/treatment/treatments-and-side-effects/complementary-and-alternative-medicine/marijuana-and-cancer.html |website = American Cancer Society |access-date = 12 July 2017 |archive-date = 22 June 2017 |archive-url = https://web.archive.org/web/20170622082320/https://www.cancer.org/treatment/treatments-and-side-effects/complementary-and-alternative-medicine/marijuana-and-cancer.html |url-status = live }}</ref> and [[Organization:American Psychological Association|American Psychological Association]]<ref name="APA">{{cite news |title = Marijuana research: Overcoming the barriers |url = http://advocacy.apascience.org/blog/2017/9/13/marijuana-research-overcoming-the-barriers |access-date = 9 October 2017 |work = American Psychological Association |date = 14 September 2017 |archive-date = 4 October 2017 |archive-url = https://web.archive.org/web/20171004035308/http://advocacy.apascience.org/blog/2017/9/13/marijuana-research-overcoming-the-barriers |url-status = dead }}</ref> have noted the obstacles that exist for conducting research on cannabis, and have called on the federal government to better enable scientific study of the drug.

Cancer Research UK say that while cannabis is being studied for therapeutic potential, "claims that there is solid "proof" that cannabis or cannabinoids can cure cancer is highly misleading to patients and their families, and builds a false picture of the state of progress in this area".<ref>{{cite web|url=http://scienceblog.cancerresearchuk.org/2012/07/25/cannabis-cannabinoids-and-cancer-the-evidence-so-far/|title=Cannabis, cannabinoids and cancer – the evidence so far|last=Arney|first=Kat|date=25 July 2012|publisher=Cancer Research UK|archive-url=https://web.archive.org/web/20140211145440/http://scienceblog.cancerresearchuk.org/2012/07/25/cannabis-cannabinoids-and-cancer-the-evidence-so-far/|archive-date=11 February 2014|url-status=dead}}</ref>

=== Brand names ===
In the US, the FDA has approved two oral cannabinoids for use as medicine: [[Biology:Tetrahydrocannabinol#Marinol|dronabinol]] and [[Chemistry:Nabilone|nabilone]].<ref name=Borgelt2013 /> Dronabinol, synthetic THC, is listed as Schedule II.<ref>{{cite web|title=Final Rule: Placement of FDA-Approved Products of Oral Solutions Containing Dronabinol [(-)-delta-9-trans-tetrahydrocannabinol (delta-9-THC)] in Schedule II|url=https://www.deadiversion.usdoj.gov/fed_regs/rules/2017/fr1122_6.htm|website=U.S. Department of Justice|access-date=2 February 2018|archive-date=28 March 2018|archive-url=https://web.archive.org/web/20180328121003/https://www.deadiversion.usdoj.gov/fed_regs/rules/2017/fr1122_6.htm|url-status=dead}}</ref> Nabilone, a synthetic cannabinoid, is also Schedule II, indicating high potential for side effects and addiction.<ref name=Svrakic2012 /> Both received approval for sale in the US in 1985, under the brand names Marinol and Cesamet.<ref>{{cite news |last1 = Clark |first1 = Amy |title = "New" Pot Pill For Chemo Patients |url = http://www.cbsnews.com/news/new-pot-pill-for-chemo-patients/ |access-date = 26 July 2017 |work = CBS News |agency = Associated Press |date = 16 May 2006 |archive-date = 28 July 2017 |archive-url = https://web.archive.org/web/20170728172927/http://www.cbsnews.com/news/new-pot-pill-for-chemo-patients/ |url-status = live }}</ref> [[Chemistry:Nabiximols|Nabiximols]], an oromucosal spray derived from two strains of ''Cannabis sativa'' and containing THC and CBD,<ref name=Svrakic2012 /> is not approved in the United States, but is approved in several European countries, Canada, and New Zealand as of 2013.<ref name=Borgelt2013 /> As of 2018, medical marijuana in Canada is being legally distributed to registered patients in bud, drops and capsule forms by such companies as [[Company:Canopy Growth Corporation|Canopy Growth Corp.]] and Aurora Cannabis.

{| class="wikitable"
|-
! Generic<br />medication
! Brand <br /> name(s)
! Country
! Licensed indications
|-
| [[Chemistry:Nabilone|Nabilone]]
| Cesamet
| rowspan="2" | U.S., Canada
| rowspan="2" | [[Chemistry:Antiemetic|Antiemetic]] (treatment of nausea or vomiting) associated with chemotherapy that has failed to respond adequately to conventional therapy<ref name=Borgelt2013 />
|-
| rowspan="2"| [[Biology:Dronabinol|Dronabinol]]
|[[Biology:Tetrahydrocannabinol#Marinol|Marinol]]
|-
|Syndros
| U.S.
| Anorexia associated with AIDS–related weight loss<ref name=Borgelt2013 />
|-
|[[Chemistry:Nabiximols|Nabiximols]]
|Sativex
| Canada, New Zealand,<br />majority of the EU<ref>{{cite journal | vauthors = Abuhasira R, Shbiro L, Landschaft Y | title = Medical use of cannabis and cannabinoids containing products – Regulations in Europe and North America | journal = European Journal of Internal Medicine | volume = 49 | pages = 2–6 | date = March 2018 | pmid = 29329891 | doi = 10.1016/j.ejim.2018.01.001 }}</ref>
| Limited treatment for spasticity and neuropathic pain associated with multiple sclerosis and intractable cancer pain.<ref name=Borgelt2013 />
|}

As an [[Chemistry:Antiemetic|antiemetic]], these medications are usually used when conventional treatment for nausea and vomiting associated with cancer chemotherapy fail to work.<ref name=Borgelt2013 />

[[Chemistry:Nabiximols|Nabiximols]] is used for treatment of spasticity associated with MS when other therapies have not worked, and when an initial trial demonstrates "meaningful improvement".<ref name=Borgelt2013 /> Trials for FDA approval in the US are underway.<ref name=Borgelt2013 /> It is also approved in several European countries for overactive bladder and vomiting.<ref name=Svrakic2012 /> When sold under the trade name Sativex as a mouth spray, the prescribed daily dose in Sweden delivers a maximum of 32.4&nbsp;mg of THC and 30&nbsp;mg of [[Chemistry:Cannabidiol|CBD]]; mild to moderate dizziness is common during the first few weeks.<ref>{{cite web |url = http://www.fass.se/LIF/product?1&docType=6&specId&userType&nplId=20101019000051 |title = Produkt – FASS Allmänhet |work = fass.se |access-date = 26 December 2013 |archive-date = 19 October 2017 |archive-url = https://web.archive.org/web/20171019170842/http://www.fass.se/LIF/product?1&docType=6&specId&userType&nplId=20101019000051 |url-status = live }}</ref>

Relative to inhaled consumption, peak concentration of oral THC is delayed, and it may be difficult to determine optimal dosage because of variability in patient absorption.<ref name=Borgelt2013 />

In 1964, Albert Lockhart and Manley West began studying the health effects of traditional cannabis use in Jamaican communities. They developed, and in 1987 gained permission to market, the pharmaceutical "Canasol", one of the first cannabis extracts.<ref name="FFY">{{cite web | first=Farid F. | last=Youssef | title=Cannabis Unmasked: What it is and why it does what it does | work=UWIToday | date=June 2010 | url=https://sta.uwi.edu/uwitoday/archive/june_2010/article9.asp | accessdate=11 May 2021 | archive-date=17 March 2021 | archive-url=https://web.archive.org/web/20210317175037/https://sta.uwi.edu/uwitoday/archive/june_2010/article9.asp | url-status=live }}</ref>

== Research ==
Medical cannabis research includes any medical research on using [[Biology:Cannabis|cannabis]] as a treatment for any medical condition. For reasons including increased popular support of cannabis use, a trend of cannabis legalization, and the perception of medical usefulness, more scientists are doing medical cannabis research. Medical cannabis is broad for many conditions, each of which has its own state of research.

A 2022 review concluded that "oral, synthetic cannabis products with high THC-to-CBD ratios and sublingual, extracted cannabis products with comparable THC-to-CBD ratios may be associated with short-term improvements in chronic pain and increased risk for dizziness and sedation."<ref name="pmid35667066">{{cite journal | vauthors=McDonagh MS, Morasco BJ, Wagner J, Ahmed AY, Fu R, Kansagara D | display-authors=3 | title=Cannabis-Based Products for Chronic Pain: A Systematic Review | journal=Ann Intern Med | year=2022 | volume=175 | issue=8 | pages=1143–1153 | pmid=35667066 | doi=10.7326/M21-4520 | s2cid=249433147 | url=https://www.acpjournals.org/doi/full/10.7326/M21-4520 | access-date=19 February 2023 | archive-date=19 February 2023 | archive-url=https://web.archive.org/web/20230219233343/https://www.acpjournals.org/doi/full/10.7326/M21-4520 | url-status=live }}</ref>

== See also ==
* [[Company:Charlotte's Web (cannabis)|Charlotte's Web (cannabis)]]
* [[Unsolved:Chinese herbology|Chinese herbology]]
* Tilden's Extract

== References ==
{{Reflist}}

== Further reading ==

{{Refbegin}}
* {{cite book | title = The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research | date = 2017 | pmid = 28182367 | doi = 10.17226/24625 | url = http://nationalacademies.org/hmd/reports/2017/health-effects-of-cannabis-and-cannabinoids.aspx | website = nationalacademies.org | publisher = National Academies of Sciences, Engineering, and Medicine: The National Academies Press |  isbn = 978-0-309-45304-2 | last1 = National Academies Of Sciences | first1 = Engineering | last2 = Health Medicine | first2 = Division | author3 = Board on Population Health Public Health Practice | author4 = Committee on the Health Effects of Marijuana: An Evidence Review Research Agenda | access-date = 7 February 2017 | archive-date = 14 July 2020 | archive-url = https://web.archive.org/web/20200714035337/https://www.nationalacademies.org/hmd/Reports/2017/health-effects-of-cannabis-and-cannabinoids.aspx | url-status = live }} {{open access}}
{{Refend}}

== External links ==

* {{curlie|Society/Issues/Health/Drugs/Illegal/Pro-Legalization/Marijuana/Medical_Purposes/}}, links to websites about medical cannabis
* [http://www.cancer.gov/cancertopics/pdq/cam/cannabis/patient Information on Cannabis and Cannabinoids] from the U.S. [[Organization:National Cancer Institute|National Cancer Institute]]
* [http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/infoprof-eng.php Information on cannabis (marihuana, marijuana) and the cannabinoids] from [[Organization:Health Canada|Health Canada]]
* [https://web.archive.org/web/20090327124100/http://www.cmcr.ucsd.edu/geninfo/news.htm The Center for Medicinal Cannabis Research of the University of California]
* [http://www.cnn.com/specials/health/medical-marijuana ''Medical Marijuana''] – a 2014–2015 three-part CNN documentary produced by Sanjay Gupta
* {{NYTtopic|subjects/m/marijuana|Marijuana and Medical Marijuana}}

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