View source for Medicine:Minor physical anomalies

{{Short description|Morphological phenomenon}}
'''Minor physical anomalies''' ('''MPA'''s) are relatively minor (typically painless and, in themselves, harmless) congenital physical abnormalities consisting of features such as low-set ears, single transverse palmar crease, [[Biology:Telecanthus|telecanthus]], micrognathism, macrocephaly, [[Medicine:Hypotonia|hypotonia]] and [[Biology:Furrowed tongue|furrowed tongue]]. While MPAs may have a genetic basis, they might also be caused by factors in the fetal environment: [[Medicine:Hypoxia (medical)|anoxia]], bleeding, or [[Medicine:Infection|infection]]. MPAs have been linked to disorders of [[Medicine:Pregnancy|pregnancy]] and are thought by some to be a marker for insults to the fetal neural development towards the end of the first trimester. Thus, in the neurodevelopmental literature, they are seen as indirect indications of interferences with brain development.

MPAs have been studied in [[Medicine:Autism|autism]], [[Medicine:Down syndrome|Down syndrome]], and in [[Medicine:Schizophrenia|schizophrenia]]. A 2008 [[Meta-analysis|meta-analysis]] found that MPAs are significantly increased in the autistic population.<ref>{{cite journal |journal= Mol Psychiatry |date=2008 |volume= 15|issue= 3|pages= 300–7|title= Minor physical anomalies in autism: a meta-analysis |vauthors=Ozgen HM, Hop JW, Hox JJ, Beemer FA, van Engeland H |doi=10.1038/mp.2008.75 |pmid=18626481|doi-access= free }}</ref> A 1998 study found that 60% of its schizophrenic sample and 38% of their siblings had 6 or more MPAs (especially in the craniofacial area), while only 5% of the control group showed that many.<ref>Ismail, B I, Cantor-Graso, E, and McNeil, T P (1998). "[http://ajp.psychiatryonline.org/cgi/content/full/155/12/1695 Minor Physical Anomalies in Schizophrenic Patients and their Siblings]," ''American Journal of Psychiatry'', 155:1695-1702</ref>

The most often cited MPA, [[Medicine:High-arched palate|high arched palate]], is described in articles as a microform of a cleft palate.<ref>Baher Ismail, Elizabeth Cantor-Graae, Thomas F McNeil. "Minor physical anomalies in schizophrenic patients and their siblings." The American Journal of Psychiatry. Washington: December 1998. Vol. 155, Iss. 12; pg. 1695.</ref> Cleft palates are partly attributable to hypoxia.<ref>Guillermo Millicovsky, Malcolm C. Johnston, Proceedings of the National Academy of Sciences of the United States of America, Vol. 78, No. 9, [Part 2: Biological Sciences] (Sep., 1981), pp. 5722-5723</ref> The vaulted palate caused by nasal obstruction and consequent mouth breathing, without the lateralising effect of the tongue, can produce [[Medicine:Hypoxia (medical)|hypoxia]] at night.

Other MPAs are reported only sporadically. Capillary malformation is induced by RASA1 mutation and can be changed by hypoxia.<ref>Rob Helton, Jiankun Cui, John R. Scheel, Julie A. Ellison, Chris Ames, Claire Gibson, Barbara Blouw, Ling Ouyang, Ioannis Dragatsis, Scott Zeitlin, Randall S. Johnson, Stuart A. Lipton, and Carrolee Barlow, April 20, 2005, Brain-specific knock-out of Hypoxia inducible factor -1alpha, reduces&nbsp;— rather than increases hypoxix-ischemic damage, The Journal of Neuroscience, pp 4099-4107, http://www.jneurosci.org/cgi/content/full/25/16/4099/TBL2.</ref>  A study in the ''American Journal of Psychiatry'' by Trixler et al.:<ref>Mátyás Trixler, M.D., Ph.D., Tamás Tényi, M.D., Györgyi Csábi, M.D., Gizella Szabó, M.D., and Károly Méhes, M.D., Ph.D., Sc.D; 1997 Informative Morphogenetic Variants in Patients With Schizophrenia, and Alcohol-Dependent Patients: Beyond the Waldrop Scale, 154:691–693 . http://ajp.psychiatryonline.org/cgi/reprint/154/5/691.pdf</ref> found hemangiomas to be highly significant in schizophrenia. Exotropia is reported as having low correlation and high significance as well.<ref>See Toyota et al., (2004) Vol 13(5) "Association between schizophrenia with ocular misalignment and polyalanine length variation in PMX2B"; Human Molecular Genetics; p551; (http://hmg.oxfordjournals.org/cgi/content/abstract/13/5/551 as of 13-12-07).</ref>  It can be caused by perinatal hypoxia.<ref>R. Huo, S.K. Burden, C.S. Hoyt and W.V. Good; "Chronic cortical visual impairment in children: aetioloy, prognosis and associated neurological deficits"; The British Journal of Ophthalmology [Br J Ophthalmol], 1999 Jun; Vol. 83 (6).</ref>

== See also ==
* Incidentaloma
* [[Physics:Fluctuating asymmetry|Fluctuating asymmetry]]
* Developmental theory of crime

== References ==
{{reflist}}

== Further reading ==
* Habel, A, Elhadt, N, Sommerlad, B, Powell, J (2005) 'Delayed detection of cleft palate: an audit of newborn examination', Archive of Diseases in Childhood, 91, p238. Psychiatry, V 155, Iss 12.
* Raine, A. (2002). Annotation: The role of prefrontal deficits, low autonomic arousal, and early health factors in the development of antisocial and aggressive behavior in children. Journal of Child Psychology and Psychiatry, 43(4), 417–434.

[[Category:Congenital disorders]]

{{Sourceattribution|Minor physical anomalies}}