View source for Medicine:Romana's sign

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'''Romaña's sign''' is a medical term for the unilateral painless periorbital swelling associated with the acute stage of Chagas' disease. Not to be confused with a [[Medicine:Chagoma|chagoma]].

==Presentation==
It occurs 1-2 weeks after infection. It is due to conjunctival swelling after contamination with the vector's [[Biology:Feces|feces]], which contains the parasitic ''[[Biology:Trypanosoma cruzi|Trypanosoma cruzi]]''. Although very characteristic of Chagas' disease, not all patients with the acute form develop Romaña's sign. 

When one has Romaña's sign, one will have subcutaneous inflammatory nodule or nonpurulent unilateral palpebral [[Medicine:Edema|edema]] and [[Medicine:Conjunctivitis|conjunctivitis]] with ipsilateral regional [[Medicine:Lymphadenopathy|lymphadenopathy]]. 

==Eponym==
It is named after Cecilio Romaña, an Argentinian researcher who first described the phenomenon.<ref>{{WhoNamedIt|synd|3325}}</ref><ref>C. Romaña. Acerca de un síntoma inicial de valor para el diagnóstico de la forma aguda de la enfermedad de Chagas. La conjuntivitis schizotripanosómica unilateral (hipótesis sobre la puerta de entrada conjuntival de la enfermedad) Mision de Estudios de Patologia Regional Argentina (MEPRA), 1935, (22): 16-25. </ref>

==References==
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[[Category:Medical signs]]

{{Protozoal diseases}}
{{Eponymous medical signs for infectious disease}}

{{Sourceattribution|Romana's sign|1}}