Biology:Beta-defensin 3: Difference between revisions

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{{Short description|Protein}}
{{Short description|Protein}}
{{infobox gene}}
{{infobox gene}}
'''Beta-defensin 3''' is a [[Biology:Protein|protein]] that in humans is encoded by the ''DEFB3'' [[Biology:Gene|gene]].<ref name="pmid7628632">{{cite journal | vauthors = Bensch KW, Raida M, Mägert HJ, Schulz-Knappe P, Forssmann WG | title = hBD-1: a novel beta-defensin from human plasma | journal = FEBS Letters | volume = 368 | issue = 2 | pages = 331–5 | date = July 1995 | pmid = 7628632 | doi = 10.1016/0014-5793(95)00687-5 | s2cid = 84766207 | doi-access = free }}</ref>
'''Beta-defensin 3''' is a [[Biology:Protein|protein]] that in humans is encoded by the ''DEFB3'' [[Biology:Gene|gene]].<ref name="pmid7628632">{{cite journal | vauthors = Bensch KW, Raida M, Mägert HJ, Schulz-Knappe P, Forssmann WG | title = hBD-1: a novel beta-defensin from human plasma | journal = FEBS Letters | volume = 368 | issue = 2 | pages = 331–5 | date = July 1995 | pmid = 7628632 | doi = 10.1016/0014-5793(95)00687-5 | s2cid = 84766207 | doi-access = free | bibcode = 1995FEBSL.368..331B }}</ref>


HBD-3 was first isolated from human lesional psoriatic scales. RT-PCR showed HBD-3 to be expressed highly in skin, trachea, tongue and tonsils, with lower levels found salivary glands, uterus, kidney, bone marrow, thymus, colon, stomach, adenoid, pharynx, and larynx.<ref>{{cite journal | vauthors = Dhople V, Krukemeyer A, Ramamoorthy A | title = The human beta-defensin-3, an antibacterial peptide with multiple biological functions | journal = Biochimica et Biophysica Acta (BBA) - Biomembranes | volume = 1758 | issue = 9 | pages = 1499–512 | date = September 2006 | pmid = 16978580 | doi = 10.1016/j.bbamem.2006.07.007 | s2cid = 36461159 | doi-access =  }}</ref>
HBD-3 was first isolated from human lesional psoriatic scales. RT-PCR showed HBD-3 to be expressed highly in skin, trachea, tongue and tonsils, with lower levels found salivary glands, uterus, kidney, bone marrow, thymus, colon, stomach, adenoid, pharynx, and larynx.<ref>{{cite journal | vauthors = Dhople V, Krukemeyer A, Ramamoorthy A | title = The human beta-defensin-3, an antibacterial peptide with multiple biological functions | journal = Biochimica et Biophysica Acta (BBA) - Biomembranes | volume = 1758 | issue = 9 | pages = 1499–512 | date = September 2006 | pmid = 16978580 | doi = 10.1016/j.bbamem.2006.07.007 | s2cid = 36461159 | doi-access =  }}</ref>

Latest revision as of 02:04, 13 January 2026

Short description: Protein


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Beta-defensin 3 is a protein that in humans is encoded by the DEFB3 gene.[1]

HBD-3 was first isolated from human lesional psoriatic scales. RT-PCR showed HBD-3 to be expressed highly in skin, trachea, tongue and tonsils, with lower levels found salivary glands, uterus, kidney, bone marrow, thymus, colon, stomach, adenoid, pharynx, and larynx.[2]

References

  1. "hBD-1: a novel beta-defensin from human plasma". FEBS Letters 368 (2): 331–5. July 1995. doi:10.1016/0014-5793(95)00687-5. PMID 7628632. Bibcode1995FEBSL.368..331B. 
  2. "The human beta-defensin-3, an antibacterial peptide with multiple biological functions". Biochimica et Biophysica Acta (BBA) - Biomembranes 1758 (9): 1499–512. September 2006. doi:10.1016/j.bbamem.2006.07.007. PMID 16978580.