Biology:Karyopherin alpha 1
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Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA1 gene.[1]
Interactions
Karyopherin alpha 1 has been shown to interact with KPNB1[2][3] and UBR5.[4]
References
- ↑ "RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1". Proc Natl Acad Sci U S A 91 (16): 7633–7. Sep 1994. doi:10.1073/pnas.91.16.7633. PMID 8052633. Bibcode: 1994PNAS...91.7633C.
- ↑ Köhler, M; Speck C; Christiansen M; Bischoff F R; Prehn S; Haller H; Görlich D; Hartmann E (Nov 1999). "Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7782–91. doi:10.1128/mcb.19.11.7782. ISSN 0270-7306. PMID 10523667.
- ↑ Percipalle, P; Clarkson W D; Kent H M; Rhodes D; Stewart M (Mar 1997). "Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import". J. Mol. Biol. (ENGLAND) 266 (4): 722–32. doi:10.1006/jmbi.1996.0801. ISSN 0022-2836. PMID 9102465.
- ↑ Henderson, Michelle J; Russell Amanda J; Hird Samantha; Muñoz Marcia; Clancy Jennifer L; Lehrbach Gillian M; Calanni Sophina T; Jans David A et al. (Jul 2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. (United States) 277 (29): 26468–78. doi:10.1074/jbc.M203527200. ISSN 0021-9258. PMID 12011095.
Further reading
- "HIV-1 nuclear import: in search of a leader.". Front. Biosci. 2 (4): d578–87. 2004. doi:10.2741/A213. PMID 9366553.
- "HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr.". Mol. Med. 4 (3): 138–43. 1998. doi:10.1007/BF03401911. PMID 9562972.
- "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.". DNA Cell Biol. 23 (4): 193–205. 2004. doi:10.1089/104454904773819789. PMID 15142377. https://zenodo.org/record/1235217.
- "Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.". Proc. Natl. Acad. Sci. U.S.A. 89 (14): 6580–4. 1992. doi:10.1073/pnas.89.14.6580. PMID 1631159. Bibcode: 1992PNAS...89.6580B.
- "p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells.". AIDS Res. Hum. Retroviruses 7 (3): 303–6. 1991. doi:10.1089/aid.1991.7.303. PMID 2064827.
- "Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr.". J. Virol. 69 (12): 7909–16. 1996. doi:10.1128/JVI.69.12.7909-7916.1995. PMID 7494303.
- "HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase.". Cell 83 (4): 569–76. 1995. doi:10.1016/0092-8674(95)90097-7. PMID 7585960.
- "Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.". Proc. Natl. Acad. Sci. U.S.A. 92 (14): 6532–6. 1995. doi:10.1073/pnas.92.14.6532. PMID 7604027. Bibcode: 1995PNAS...92.6532M.
- "Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection.". J. Virol. 69 (6): 3949–54. 1995. doi:10.1128/JVI.69.6.3949-3954.1995. PMID 7745752.
- "Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences.". Science 268 (5213): 1049–53. 1995. doi:10.1126/science.7754385. PMID 7754385. Bibcode: 1995Sci...268.1049W.
- "NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein.". Virology 206 (1): 116–25. 1995. doi:10.1016/S0042-6822(95)80026-3. PMID 7831767.
- "HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator.". Cell 80 (3): 379–88. 1995. doi:10.1016/0092-8674(95)90488-3. PMID 7859280.
- "Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes.". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2008–11. 1995. doi:10.1073/pnas.92.6.2008. PMID 7892216. Bibcode: 1995PNAS...92.2008M.
- "The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 6992–6. 1994. doi:10.1073/pnas.91.15.6992. PMID 8041734. Bibcode: 1994PNAS...91.6992V.
- "The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 7311–5. 1994. doi:10.1073/pnas.91.15.7311. PMID 8041786. Bibcode: 1994PNAS...91.7311H.
- "A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells.". Nature 365 (6447): 666–9. 1993. doi:10.1038/365666a0. PMID 8105392. Bibcode: 1993Natur.365..666B.
- "Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention.". Mol. Med. 1 (2): 217–30. 1996. doi:10.1007/BF03401569. PMID 8529100.
- "Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import.". J. Virol. 70 (2): 1027–32. 1996. doi:10.1128/JVI.70.2.1027-1032.1996. PMID 8551560.
- "Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 367–71. 1996. doi:10.1073/pnas.93.1.367. PMID 8552640. Bibcode: 1996PNAS...93..367B.
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