Biology:DOK5
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Docking protein 5 is a protein that in humans is encoded by the DOK5 gene.[1][2]
Function
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.[2]
Interactions
DOK5 has been shown to interact with RET proto-oncogene.[1][3]
References
- ↑ 1.0 1.1 "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation". J Cell Biol 154 (2): 345–54. Jul 2001. doi:10.1083/jcb.200102032. PMID 11470823. PMC 2150770. http://edoc.mdc-berlin.de/4926/1/4926oa.pdf.
- ↑ 2.0 2.1 "Entrez Gene: DOK5 docking protein 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55816.
- ↑ "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. 2004. doi:10.1074/jbc.M403726200. PMID 15286081.
Further reading
- "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052.
- "Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of human dok-5 protein". Acta Crystallogr. D 58 (Pt 12): 2170–2. 2003. doi:10.1107/S090744490201644X. PMID 12454490.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. 2003. doi:10.1038/sj.gene.6363891. PMID 12595900.
- "Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5". J. Biol. Chem. 278 (28): 25323–30. 2003. doi:10.1074/jbc.M212430200. PMID 12730241.
- "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. 2004. doi:10.1074/jbc.M403726200. PMID 15286081.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514.
- "Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation". Cell. Signal. 18 (11): 1995–2003. 2007. doi:10.1016/j.cellsig.2006.03.007. PMID 16647839.
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