Biology:SLC4A2
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Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene.[1][2] AE2 is functionally similar to the Band 3 Cl−/HCO3− exchange protein.
Mice have been used to explore the function of AE2. AE2 contributes to basolateral membrane HCO3− transport in the gastrointestinal tract.[3] AE2 is required for spermiogenesis in mice.[4] AE2 is required for normal osteoclast function.[5][6] The activity of AE2 is sensitive to pH.[7]
AE3 has been suggested as a target for prevention of diabetic vasculopathy.[8]
See also
References
- ↑ Tanner MJ (Mar 1993). "Molecular and cellular biology of the erythrocyte anion exchanger (AE1)". Semin Hematol 30 (1): 34–57. PMID 8434259.
- ↑ "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6522.
- ↑ "AE2 Cl−/HCO3− exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon". Am. J. Physiol. Gastrointest. Liver Physiol. 298 (4): G493–503. April 2010. doi:10.1152/ajpgi.00178.2009. PMID 20110461.
- ↑ "Anion exchanger 2 is essential for spermiogenesis in mice". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15847–52. December 2003. doi:10.1073/pnas.2536127100. PMID 14673081.
- ↑ "HCO3−/Cl− anion exchanger SLC4A2 is required for proper osteoclast differentiation and function". Proc. Natl. Acad. Sci. U.S.A. 105 (44): 16934–9. November 2008. doi:10.1073/pnas.0808763105. PMID 18971331.
- ↑ "Targeted disruption of the Cl−/HCO3− exchanger Ae2 results in osteopetrosis in mice". Proc. Natl. Acad. Sci. U.S.A. 106 (5): 1638–41. February 2009. doi:10.1073/pnas.0811682106. PMID 19164575.
- ↑ "Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH". J. Biol. Chem. 284 (10): 6126–39. March 2009. doi:10.1074/jbc.M802051200. PMID 19103596.
- ↑ "Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway". Apoptosis 15 (6): 693–704. June 2010. doi:10.1007/s10495-010-0477-9. PMID 20180022.
Further reading
- "Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney.". Biochim. Biophys. Acta 1130 (3): 326–8. 1992. doi:10.1016/0167-4781(92)90446-7. PMID 1562608.
- "Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3.". J. Biol. Chem. 263 (21): 10212–8. 1988. PMID 2968981.
- "Cloning and structural characterization of a human non-erythroid band 3-like protein.". EMBO J. 5 (6): 1205–14. 1986. PMID 3015590.
- "Chromosomal localization of a human band 3-like gene to region 7q35----7q36.". Am. J. Hum. Genet. 39 (3): 307–16. 1986. PMID 3020980.
- "Identification of a band-3 binding site near the N-terminus of erythrocyte membrane protein 4.2.". Biochem. J.. 309 ( Pt 2): 677–81. 1995. PMID 7626035.
- "Expression of the anion exchanger (AE) gene family in human brain. Identification of a new AE protein: AE0.". Brain Res. Mol. Brain Res. 25 (1–2): 97–104. 1995. doi:10.1016/0169-328X(94)90283-6. PMID 7984058.
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene.". Genomics 39 (1): 74–85. 1997. doi:10.1006/geno.1996.4467. PMID 9027488.
- "In situ detection of AE2 anion-exchanger mRNA in the human liver.". Cell Tissue Res. 291 (3): 481–8. 1998. doi:10.1007/s004410051017. PMID 9477304.
- "Anion exchanger 2 (AE2) binds to erythrocyte ankyrin and is colocalized with ankyrin along the basolateral plasma membrane of human gastric parietal cells.". Eur. J. Cell Biol. 75 (3): 232–6. 1998. doi:10.1016/s0171-9335(98)80117-9. PMID 9587054.
- "Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts.". Cell Biol. Int. 22 (7–8): 551–62. 1999. doi:10.1006/cbir.1998.0299. PMID 10452823.
- "Chloride-bicarbonate exchangers in the human fetal pancreas.". Biochem. Biophys. Res. Commun. 263 (2): 315–21. 1999. doi:10.1006/bbrc.1999.1367. PMID 10491290.
- "Primary structure of a sperm cell anion exchanger and its messenger ribonucleic acid expression during spermatogenesis.". Biol. Reprod. 61 (4): 981–6. 1999. doi:10.1095/biolreprod61.4.981. PMID 10491633.
- "Localization of a gene for autosomal recessive distal renal tubular acidosis with normal hearing (rdRTA2) to 7q33-34.". Am. J. Hum. Genet. 65 (6): 1656–65. 2000. doi:10.1086/302679. PMID 10577919.
- "Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene.". Biochem. Biophys. Res. Commun. 267 (1): 228–35. 2000. doi:10.1006/bbrc.1999.1951. PMID 10623603.
- "Identification of the Carbonic Anhydrase II Binding Site in the Cl−/HCO3− Anion Exchanger AE1.". Biochemistry 39 (18): 5527–33. 2000. doi:10.1021/bi992564p. PMID 10820026.
- "Identification of the full-length AE2 (AE2a) isoform as the Golgi-associated anion exchanger in fibroblasts.". J. Histochem. Cytochem. 49 (2): 259–69. 2001. doi:10.1177/002215540104900213. PMID 11156694.
- "Pendrin: an apical Cl−/OH−/HCO3− exchanger in the kidney cortex.". Am. J. Physiol. Renal Physiol. 280 (2): F356–64. 2001. doi:10.1152/ajprenal.2001.280.2.f356. PMID 11208611.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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