Biology:SLC4A3
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Anion exchange protein 3 is a membrane transport protein that in humans is encoded by the SLC4A3 gene.[1][2] AE3 is functionally similar to the Band 3 Cl−/HCO3− exchange protein but it is expressed primarily in brain neurons and in the heart. Like AE2 its activity is sensitive to pH.[3][4] AE3 mutations have been linked to seizures.[5][6]
See also
References
- ↑ "Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36". Genomics 22 (3): 605–9. Jan 1995. doi:10.1006/geno.1994.1433. PMID 8001971.
- ↑ "Entrez Gene: SLC4A3 solute carrier family 4, anion exchanger, member 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6508.
- ↑ "Bicarbonate homeostasis in excitable tissues: role of AE3 Cl-/HCO3- exchanger and carbonic anhydrase XIV interaction". Am. J. Physiol., Cell Physiol. 297 (5): C1091–102. November 2009. doi:10.1152/ajpcell.00177.2009. PMID 19692653.
- ↑ "Regulation of intestinal Cl-/HCO3- exchanger SLC26A3 by intracellular pH". Am. J. Physiol., Cell Physiol. 296 (6): C1279–90. June 2009. doi:10.1152/ajpcell.00638.2008. PMID 19321737.
- ↑ "Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold". Mol. Cell. Biol. 26 (1): 182–91. January 2006. doi:10.1128/MCB.26.1.182-191.2006. PMID 16354689.
- ↑ "Characterization of an epilepsy-associated variant of the human Cl-/HCO3(-) exchanger AE3". Am. J. Physiol., Cell Physiol. 297 (3): C526–36. September 2009. doi:10.1152/ajpcell.00572.2008. PMID 19605733.
Further reading
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