Medicine:Vascular-targeting agent

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A vascular-targeting agent (VTA) or vascular disrupting agent (VDA) is a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.[1] VTAs can be small-molecule or ligand-based.

Small-molecule VTAs include:

  • microtubule destabilizing drugs such as combretastatin A-4 disodium phosphate (CA4P), ZD6126, AVE8062, Oxi 4503
  • vadimezan (ASA404)

Clinical trials

Phase II : ZD6126, CA4P, plinabulin (NPI-2358)[2][3][4]

Phase III : DMXAA (ASA404).

References

  1. ↑ Thorpe, Philip E. (2004). "Vascular Targeting Agents as Cancer Therapeutics". Clinical Cancer Research 10 (2): 415–427. doi:10.1158/1078-0432.CCR-0642-03. PMID 14760060. http://clincancerres.aacrjournals.org/cgi/reprint/10/2/415.pdf. 
  2. ↑ "NPI-2358". clinicaltrials.gov. http://clinicaltrials.gov/ct2/results?term=NPI-2358&Search=Search. 
  3. ↑ Monica M. Mita (2010). "Phase 1 First-in-Human Trial of the Vascular Disrupting Agent Plinabulin (NPI-2358) in Patients with Solid Tumors or Lymphomas". Clin Cancer Res 16 (23): 5892–5899. doi:10.1158/1078-0432.CCR-10-1096. PMID 21138873. 
  4. ↑ Staff (2009). "Clinical Trials Update". Genetic Engineering & Biotechnology News 29 (8): 58. 



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