Biology:Pseudoprotease

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Comparison of Azurocidin 1 structure (pseudoprotease) to Chymotrypsin (functional protease) of same superfamily

Pseudoproteases are catalytically-deficient pseudoenzyme variants of proteases that are represented across the kingdoms of life.[1][2]

Examples

Superfamilies containing pseudoenzymes with inactive triads [3]
Superfamily Families containing pseudoenzymes Examples
CA clan C1, C2, C19 Calpamodulin
CD clan C14 CFLAR
SC clan S9, S33 Neuroligin
SK clan S14 ClpR
SR clan S60 Serotransferrin domain 2
ST clan S54 RHBDF1
PA clan S1 Azurocidin 1
PB clan T1 PSMB3

See also

References

  1. ↑ Fischer, Katja; Reynolds, Simone L. (2015-05-15). "Pseudoproteases: mechanisms and function" (in en). Biochemical Journal 468 (1): 17–24. doi:10.1042/BJ20141506. ISSN 1470-8728. PMID 25940733. http://www.biochemj.org/content/468/1/17. 
  2. ↑ "Sequence and structural differences between enzyme and nonenzyme homologs". Structure 10 (10): 1435–51. October 2002. doi:10.1016/s0969-2126(02)00861-4. PMID 12377129. 
  3. ↑ Fischer, Katja; Reynolds, Simone L. (2015-05-15). "Pseudoproteases: mechanisms and function" (in en). Biochemical Journal 468 (1): 17–24. doi:10.1042/BJ20141506. ISSN 1470-8728. PMID 25940733. http://www.biochemj.org/content/468/1/17. 



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