Biology:LRRC8B
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Leucine-rich repeat-containing protein 8B is a protein that in humans is encoded by the LRRC8B gene.[1] Researchers have found out that this protein, along with the other LRRC8 proteins LRRC8A, LRRC8C, LRRC8D, and LRRC8E, is sometimes a subunit of the heteromer protein volume-regulated anion channel (VRAC).[2] VRACs are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes, such as taurine or glutamate, across the plasma membrane,[3] and that is not the only function these channels have been linked to. While LRRC8B is one of many proteins that can be part of VRAC, research has found that it is not as crucial to the activity of the channel in comparison to LRRC8A and LRRC8D.[4][5][6] However, while we know that LRRC8A and LRRC8D are necessary for VRAC function, other studies have found that they are not sufficient for the full range of usual VRAC activity.[7] This is where the other LRRC8 proteins come in, such as LRRC8B, as the different composition of these subunits affects the range of specificity for VRACs.[8][6]
In addition to its role in VRACs, the LRRC8 protein family is also associated with agammaglobulinemia-5.[9]
References
- ↑ "Entrez Gene: LRRC8A leucine rich repeat containing 8 family, member A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56262.
- ↑ Voss, Felizia; Ullrich, Florian; Münch, Jonas (2014-05-09). "Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.". Science 344 (6184): 634–8. doi:10.1126/science.1252826. PMID 24790029. Bibcode: 2014Sci...344..634V. http://edoc.mdc-berlin.de/14008/1/14008oa.pdf.
- ↑ Jentsch, Thomas J. (2016-05-17). "VRACs and other ion channels and transporters in the regulation of cell volume and beyond". Nature Reviews Molecular Cell Biology 17 (2): 293–3017. doi:10.1038/nrm.2016.29. ISSN 1471-0072. PMID 27033257. https://exlibris.colgate.edu:2231/pubmed/?term=VRACs%20and%20other%20ion%20channels%20and%20transporters%20in%20the%20regulation%20of%20cell%20volume%20and%20beyond.
- ↑ Hyzinski-García, María C; Rudkouskaya, Alena; Mongin, Alexander (2014-11-15). "LRRC8A protein is indispensable for swelling-activated and ATP-induced release of excitatory amino acids in rat astrocytes.". The Journal of Physiology 592 (22): 4855–62. doi:10.1113/jphysiol.2014.278887. PMID 25172945.
- ↑ Yamada, Toshiki; Wondergem, Robert; Morrison, Rebecca (2016-10-04). "Leucine-rich repeat containing protein LRRC8A is essential for swelling-activated Cl- currents and embryonic development in zebrafish.". Physiological Reports 4 (19): e12940. doi:10.14814/phy2.12940. PMID 27688432.
- ↑ 6.0 6.1 Planells‐Cases, Rosa; Lutter, Darius; Guyader, Charlotte (2015-12-14). "Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt‐based anti‐cancer drugs". EMBO Journal 34 (24): 2993–3008. doi:10.15252/embj.201592409. PMID 26530471.
- ↑ Okada, T; Islam, MR; Tsiferova, NA (2016-10-20). "Specific and essential but not sufficient roles of LRRC8A in the activity of volume-sensitive outwardly rectifying anion channel (VSOR).". Channels 11 (2): 109–120. doi:10.1080/19336950.2016.1247133. PMID 27764579.
- ↑ Lutter, D; Ullrich, F; Lueck, JC (2017-03-15). "Selective transport of neurotransmitters and –modulators by distinct volume-regulated LRRC8 anion channels". Journal of Cell Science 130 (6): 1122–1133. doi:10.1242/jcs.196253. PMID 28193731. http://edoc.mdc-berlin.de/16332/1/16332oa.pdf.
- ↑ Sawada, A; Takihara, Y; Kim, JY (December 2003). "A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans.". Journal of Clinical Investigation 112 (11): 1707–13. doi:10.1172/JCI18937. PMID 14660746.
Further reading
- "VRACs and other ion channels and transporters in the regulation of cell volume and beyond". Nature Reviews Molecular Cell Biology 17 (2): 293–307. 2016. doi:10.1038/nrm.2016.29. PMID 27033257.
- "Cellular function and control of volume-regulated anion channels". Cell Biochemistry and Biophysics 35 (3): 263–74. 2001. doi:10.1385/CBB:35:3:263. PMID 11894846.
- "Volume-regulated anion channel – a frenemy within the brain". Pflügers Archiv 468 (3): 421–441. 2016. doi:10.1007/s00424-015-1765-6. PMID 26620797.
- "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. 2000. doi:10.1093/dnares/7.1.65. PMID 10718198.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans". J. Clin. Invest. 112 (11): 1707–13. 2004. doi:10.1172/JCI18937. PMID 14660746.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins". FEBS Lett. 564 (1–2): 147–52. 2004. doi:10.1016/S0014-5793(04)00332-1. PMID 15094057.
- "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "LRRC8 extracellular domain is composed of 17 leucine-rich repeats". Mol. Immunol. 41 (5): 561–2. 2004. doi:10.1016/j.molimm.2004.04.001. PMID 15183935.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. 2007. doi:10.1093/dnares/12.2.117. PMID 16303743.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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