Biology:Neuregulin 4
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.[1][2][3]
Function
The neuregulins, including NRG4, activate erb-b2 receptor tyrosine kinase 4 (ERBB4) to initiating cell signaling through cytosolic tyrosine phosphorylation.[3]
Clinical significance
Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival.[4]
References
- ↑ "Entrez Gene: NRG4 neuregulin 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=145957.
- ↑ "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. December 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- ↑ 3.0 3.1 "Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase". Oncogene 18 (17): 2681–9. April 1999. doi:10.1038/sj.onc.1202631. PMID 10348342.
- ↑ "Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients". Br. J. Cancer 91 (12): 2034–41. December 2004. doi:10.1038/sj.bjc.6602251. PMID 15583696.
Further reading
- "ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis". Ann. Oncol. 19 (1): 73–80. January 2008. doi:10.1093/annonc/mdm431. PMID 17962208.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Characterization of the cell membrane-associated products of the Neuregulin 4 gene.". Oncogene 27 (5): 715–20. 2008. doi:10.1038/sj.onc.1210689. PMID 17684490.
- "Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer.". Clin. Cancer Res. 13 (11): 3147–55. 2007. doi:10.1158/1078-0432.CCR-06-2237. PMID 17545517.
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