Biology:NPTN
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Neuroplastin is a protein that in humans is encoded by the NPTN gene.[1][2][3]
Neuroplastin is a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. The alpha and beta transcripts show differential localization within the brain.[3]
In 2014, in a study led by Dr. Sylvane Desrivières, of King's College London's Institute of Psychiatry found that "teenagers who had a highly functioning NPTN gene performed better in intelligence tests"[4][5][6]
References
- ↑ "A "double adaptor" method for improved shotgun library construction". Anal Biochem 236 (1): 107–13. Jun 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- ↑ "Large-scale concatenation cDNA sequencing". Genome Res 7 (4): 353–8. Jun 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- ↑ 3.0 3.1 "Entrez Gene: NPTN neuroplastin". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27020.
- ↑ Is intelligence written in the genes?
- ↑ Researchers Find Gene that Links Grey Matter with Intelligence
- ↑ Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents
Further reading
- "Synaptic membrane glycoproteins gp65 and gp55 are new members of the immunoglobulin superfamily.". J. Biol. Chem. 272 (2): 821–7. 1997. doi:10.1074/jbc.272.2.821. PMID 8995369.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. 2005. doi:10.1038/nbt971. PMID 15146197.
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. 2005. doi:10.1110/ps.04682504. PMID 15340161.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Association study of putative promoter polymorphisms in the neuroplastin gene and schizophrenia.". Neurosci. Lett. 411 (3): 168–73. 2007. doi:10.1016/j.neulet.2006.08.042. PMID 17123723.
- "The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain.". Brain Res. 1134 (1): 107–12. 2007. doi:10.1016/j.brainres.2006.11.090. PMID 17196182.
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