Biology:SV2A
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Synaptic vesicle glycoprotein 2A is a ubiquitous synaptic vesicle protein that in humans is encoded by the SV2A gene.[1][2][3] The protein is targeted by the anti-epileptic drugs (anticonvulsants) levetiracetam and brivaracetam.[4]
See also
References
- ↑ "Brain contains two forms of synaptic vesicle protein 2". Proceedings of the National Academy of Sciences of the United States of America 90 (6): 2150–4. Mar 1993. doi:10.1073/pnas.90.6.2150. PMID 7681585. Bibcode: 1993PNAS...90.2150B.
- ↑ "Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)". Proceedings of the National Academy of Sciences of the United States of America 96 (26): 15268–73. Dec 1999. doi:10.1073/pnas.96.26.15268. PMID 10611374. Bibcode: 1999PNAS...9615268C.
- ↑ "Entrez Gene: SV2A synaptic vesicle glycoprotein 2A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9900.
- ↑ "Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures". Neuropsychiatric Disease and Treatment 5: 467–76. 2009. doi:10.2147/ndt.s4844. PMID 19777068.
Further reading
- "SV2, a brain synaptic vesicle protein homologous to bacterial transporters". Science 257 (5074): 1271–3. Aug 1992. doi:10.1126/science.1519064. PMID 1519064. Bibcode: 1992Sci...257.1271B.
- "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (5): 277–86. Oct 1998. doi:10.1093/dnares/5.5.277. PMID 9872452.
- "The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface". The Journal of Biological Chemistry 275 (1): 451–60. Jan 2000. doi:10.1074/jbc.275.1.451. PMID 10617638.
- "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. Nov 2000. doi:10.1101/gr.143000. PMID 11076863.
- "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. Mar 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. Sep 2000. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- "The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam". Proceedings of the National Academy of Sciences of the United States of America 101 (26): 9861–6. Jun 2004. doi:10.1073/pnas.0308208101. PMID 15210974. Bibcode: 2004PNAS..101.9861L.
- "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. Oct 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". Journal of Proteome Research 4 (2): 306–15. 2005. doi:10.1021/pr0498436. PMID 15822905.
- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research 12 (2): 117–26. 2007. doi:10.1093/dnares/12.2.117. PMID 16303743.
- "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415–8. Jan 2006. doi:10.1093/nar/gkj139. PMID 16381901.
External links
- Overview of all the structural information available in the PDB for UniProt: Q7L0J3 (Synaptic vesicle glycoprotein 2A) at the PDBe-KB.
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