Biology:BNIP2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene.[1][2]
Function
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. Though the specific function is unknown, it interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL-2, also an apoptotic protector.[2]
Interactions
BNIP2 has been shown to interact with:
References
- ↑ 1.0 1.1 "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". Cell 79 (2): 341–51. November 1994. doi:10.1016/0092-8674(94)90202-X. PMID 7954800.
- ↑ 2.0 2.1 "Entrez Gene: BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=663.
- ↑ 3.0 3.1 "The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP". J. Biol. Chem. 275 (48): 37742–51. December 2000. doi:10.1074/jbc.M004897200. PMID 10954711.
- ↑ 4.0 4.1 "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42". J. Biol. Chem. 274 (46): 33123–30. November 1999. doi:10.1074/jbc.274.46.33123. PMID 10551883.
- ↑ "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". Biochem. Biophys. Res. Commun. 308 (2): 379–85. August 2003. doi:10.1016/s0006-291x(03)01387-1. PMID 12901880.
- ↑ "Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2". J. Biol. Chem. 275 (19): 14415–22. May 2000. doi:10.1074/jbc.275.19.14415. PMID 10799524.
External links
- Human BNIP2 genome location and BNIP2 gene details page in the UCSC Genome Browser.
Further reading
- "Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2". Brain Res. Brain Res. Rev. 37 (1–3): 335–42. 2002. doi:10.1016/S0165-0173(01)00138-2. PMID 11744098.
- "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region". Cell Death Differ. 6 (4): 314–25. 1999. doi:10.1038/sj.cdd.4400493. PMID 10381623.
- "The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence". J. Biol. Chem. 277 (9): 7483–92. 2002. doi:10.1074/jbc.M109459200. PMID 11741952.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1". J. Biol. Chem. 278 (46): 45903–14. 2003. doi:10.1074/jbc.M304514200. PMID 12944407.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain". Exp. Cell Res. 303 (2): 263–74. 2005. doi:10.1016/j.yexcr.2004.08.044. PMID 15652341.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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