Biology:HEBP1
From HandWiki
 Generic protein structure example |
Heme binding protein 1 is a protein that in humans is encoded by the HEBP1 gene.[1]
Function
The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells.[1]
References
Further reading
- "Characterization of a human and mouse tetrapyrrole-binding protein". Archives of Biochemistry and Biophysics 407 (2): 196–201. Nov 2002. doi:10.1016/s0003-9861(02)00471-x. PMID 12413491.
- "F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor". Journal of Immunology 178 (3): 1450–6. Feb 2007. doi:10.4049/jimmunol.178.3.1450. PMID 17237393.
- "Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins". Journal of Molecular Graphics & Modelling 29 (3): 396–405. Nov 2010. doi:10.1016/j.jmgm.2010.07.008. PMID 20800521.
- "Identification and characterization of an endogenous chemotactic ligand specific for FPRL2". The Journal of Experimental Medicine 201 (1): 83–93. Jan 2005. doi:10.1084/jem.20041277. PMID 15623572.
- "Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3". Journal of Immunology 187 (3): 1475–85. Aug 2011. doi:10.4049/jimmunol.1003545. PMID 21709160.
- "Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches". Brain Research. Molecular Brain Research 74 (1–2): 175–81. Dec 1999. doi:10.1016/s0169-328x(99)00277-6. PMID 10640688.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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