Biography:Richard Gilbertson

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Short description: British paediatric oncology clinician scientist
Richard Gilbertson

FRS FMedSci FRCP
Professor Richard Gilbertson.jpg
Born
Richard James Gilbertson
Alma materNewcastle University (B.Med.Sci, MB BS, PhD)
AwardsFellow of the Royal Society, Fellow of the Academy of Medical Sciences, Fellow of the Royal College of Physicians
Scientific career
InstitutionsCancer Research UK Cambridge Institute, University of Cambridge

St. Jude Children's Research Hospital

Newcastle University
Thesis (1998)
Websitewww.cruk.cam.ac.uk/research-groups/gilbertson-group

Professor Richard James Gilbertson FRS FMedSci FRCP is a paediatric oncology clinician scientist and a Senior Group Leader at the Cancer Research UK Cambridge Institute, University of Cambridge.[1] He is the Li Ka Shing Chair of Oncology,[2] and Director of the CRUK Cambridge Major Centre[3] and the Children's Brain Tumour Centre of Excellence.[4]

Education

Gilbertson attended Medical School at Newcastle University,[5] graduating with Bachelor of Medical Science, Bachelor of Medicine, Bachelor of Surgery degrees in 1992.[6] He went on to complete his PhD in 1998 as an MRC Clinical Training Fellow with Professors Andrew Pearson and John Lunec before becoming an MRC Clinical Scientist in 1998.[7]

Career and research

Gilbertson's research focuses on understanding the link between normal development and the origins of cancer, with a particular focus on children's brain tumours.[8] He has shown that clinically distinct subtypes of childhood medulloblastoma and ependymoma arise within different lineages of developing brain and are driven by distinct mutations in their DNA.[9][10][11][12] His work has also shown that a combination of stem cell mutagenesis and extrinsic factors that enhance the proliferation of progenitor cell populations across multiple organs ultimately determines organ cancer risk.[13][14]

In 2000, Gilbertson joined the St Jude Children's Research Hospital.[15] There, he became the founding director of the Molecular Clinical Trials Core and the co-leader of the Neurobiology and Brain Tumor Program.[16] In 2011, he was named executive vice president of St. Jude and director of its Comprehensive Cancer Centre.[17][18][19] In 2014 he was also appointed Scientific Director of St. Jude Children's Research Hospital.

In 2015, he returned to the UK as the Li Ka Shing Chair of Oncology, head of the Department of Oncology, senior group leader at the Cancer Research UK Cambridge Institute at the University of Cambridge and Director of the CRUK Cambridge Major Centre.[20]

He was elected: Fellow of the Academy of Medical Sciences (FMedSci) in 2017;[21] Fellow of the European Academy of Cancer Sciences in 2017;[22] and Fellow of the Royal Society of London (FRS) 2022.[23] His certificate for election to Fellow of the Royal Society (FRS) in 2022 reads:

  • A paediatric oncology clinician scientist, Richard has pioneered the field of cross-species genomics, deploying data generated from patients to identify the lineage origins of childhood brain tumours; build accurate models of these cancers; and design new treatments. He has also generated organism-wide maps of cancer risk across all organs and ages, helping to understand the relative contributions of cell lineage, gene mutation and tissue damage to tumourigenesis.[24]

Awards and honours

  • International Society of Pediatric Oncology Schweisguth Prize, 1998[25]
  • Royal College of Paediatrics and Child Health SPARKS Young Investigator of the Year, 2000[26]
  • British Paediatric Neurology Association Ronnie McKeith Prize, 2002[27]
  • Brain Tumor Society Sydney Schlobohm Leadership Chair of Research, 2006[28][29]
  • Malia's Cord Foundation Harold C. Schott Research Chair, 2008[30]
  • American Association of Neurological Surgeons Hunt-Wilson Lectureship, 2011[31]
  • Elected to the American Society for Clinical Investigation, 2013[32]
  • Member, Faculty of 1000[citation needed]
  • Elected Fellow of the Academy of Medical Sciences, 2017[33]
  • Elected Fellow of the European Academy of Cancer Sciences 2017[citation needed]
  • Elected Fellow of the Royal College of Physicians 2020[citation needed]
  • Elected Fellow of the Royal Society 2022[34]
  • Society of Memorial Sloan Kettering Prize, 2022[35]
  • Elected Fellow of EMBO 2022

References

  1. ↑ "Gilbertson Group" (in en-GB). https://www.cruk.cam.ac.uk/research-groups/gilbertson-group. 
  2. ↑ "Childhood brain tumour expert to lead Cambridge Cancer Centre" (in en). 2015-03-26. https://www.cam.ac.uk/news/childhood-brain-tumour-expert-to-lead-cambridge-cancer-centre. 
  3. ↑ "Cancer centres receive £15m boost" (in en-GB). BBC News. 2015-06-26. https://www.bbc.com/news/uk-england-33273226. 
  4. ↑ Davis, Nicola (2018-05-01). "Brain tumour research to get £18m injection" (in en-GB). The Guardian. ISSN 0261-3077. https://www.theguardian.com/science/2018/may/01/brain-tumour-research-to-get-18m-injection. 
  5. ↑ "Man on a mission to beat cancer" (in en). 2016-11-14. https://www.cam.ac.uk/research/features/man-on-a-mission-to-beat-cancer. 
  6. ↑ "Richard J. Gilbertson". http://www.sontagfoundation.org/recipients/richard-j-gilbertson/. 
  7. ↑ "A Conversation with Richard J. Gilbertson, MD, PhD - The ASCO Post". https://www.ascopost.com/issues/november-1-2011/a-conversation-with-richard-j-gilbertson-md-phd/. 
  8. ↑ Richard Gilbertson publications indexed by Google Scholar
  9. ↑ Gajjar, Amar; Pfister, Stefan M.; Taylor, Michael D.; Gilbertson, Richard J. (2014-11-15). "Molecular insights into pediatric brain tumors have the potential to transform therapy". Clinical Cancer Research 20 (22): 5630–5640. doi:10.1158/1078-0432.CCR-14-0833. ISSN 1078-0432. PMID 25398846. 
  10. ↑ "Expert Opinion – Professor Richard Gilbertson talks children's cancers". 26 November 2015. https://scienceblog.cancerresearchuk.org/2015/11/26/expert-opinion-professor-richard-gilbertson-talks-childrens-cancers/. 
  11. ↑ Gibson, P (2010). "Subtypes of medulloblastoma have distinct developmental origins". Nature 468 (7327): 1095–1099. doi:10.1038/nature09587. PMID 21150899. 
  12. ↑ Parker, M (2014). "C11orf95-RELA fusions drive oncogenic NF-kappaB signalling in ependymoma". Nature 506 (7489): 451–455. doi:10.1038/nature13109. PMID 24553141. 
  13. ↑ Zhu, Liqin; Finkelstein, David; Gao, Culian; Shi, Lei; Wang, Yongdong; López-Terrada, Dolores; Wang, Kasper; Utley, Sarah et al. (2016-08-25). "Multi-organ Mapping of Cancer Risk". Cell 166 (5): 1132–1146.e7. doi:10.1016/j.cell.2016.07.045. ISSN 0092-8674. PMID 27565343. 
  14. ↑ "Cancer: 'Perfect storm' of cancer risk" (in en). Nature 537 (7619): 140. 2016-09-07. doi:10.1038/537140c. ISSN 1476-4687. PMID 27604915. Bibcode: 2016Natur.537S.140.. 
  15. ↑ "St. Jude Children's Research Hospital scientific director announces resignation" (in en). https://www.stjude.org/media-resources/news-releases/2015-medicine-science-news/scientific-director-announces-resignation.html. 
  16. ↑ "Professor Richard Gilbertson". https://cambridgebrc.nihr.ac.uk/research/cancer/contact-details/. 
  17. ↑ "A Conversation with Richard J. Gilbertson, MD, PhD - The ASCO Post". https://www.ascopost.com/issues/november-1-2011/a-conversation-with-richard-j-gilbertson-md-phd/. 
  18. ↑ Bartlett, James. "British Cancer Researcher on Why He Moved to the U.S." (in en-US). http://www.bbcamerica.com/shows//blog/2014/08/british-researcher-memphis-childrens-cancer-respect-borders. 
  19. ↑ "Coming home to the UK: an interview with Richard Gilbertson" (in en). 2016-07-20. https://www.cancerresearchuk.org/funding-for-researchers/research-features/2016-08-10-researcher-annual-publication-richard-gilbertson-interview. 
  20. ↑ "Professor Richard Gilbertson appointed Head of Department - Department of Oncology" (in en). https://www.oncology.cam.ac.uk/news-events/gilbertson-head. 
  21. ↑ "Professor Richard Gilbertson | The Academy of Medical Sciences". https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Professor-Richard-Gilbertson-0023663. 
  22. ↑ "Fellows | European Academy of Cancer Sciences". https://www.europeancanceracademy.eu/fellows. 
  23. ↑ "Outstanding scientists elected as Fellows and Foreign Members of the Royal Society | Royal Society". https://royalsociety.org/news/2022/05/new-fellows-2022/. 
  24. ↑ "Richard Gilbertson". https://royalsociety.org/people/richard-gilbertson-35830/. 
  25. ↑ "Previous Schweisguth Prize Winners". https://siop-online.org/previous-schweisguth-prize-winners/. 
  26. ↑ "Dr Simon Newell Early Career Investigator of the Year (Sparks) award" (in en). https://www.rcpch.ac.uk/education-careers/fellowships-and-prizes/dr-simon-newell-early-career-investigator-year-sparks-award. 
  27. ↑ "British Paediatric Neurology Association". https://bpna.org.uk/?page=mackeith-prize-lecturers. 
  28. ↑ Gutmann, David H.; Gilbertson, Richard J. (2007-06-15). "Tumorigenesis in the Brain: Location, Location, Location" (in en). Cancer Research 67 (12): 5579–5582. doi:10.1158/0008-5472.CAN-07-0760. ISSN 0008-5472. PMID 17575119. http://cancerres.aacrjournals.org/content/67/12/5579. Retrieved 2019-06-11. 
  29. ↑ "Honors & awards" (in en). https://www.stjude.org/about-st-jude/honors-and-awards.html. 
  30. ↑ "ALSF CORD Fund History" (in en). 2019-03-07. https://www.alexslemonade.org/campaign/alsf-cord-fund/alsf-cord-fund-history. 
  31. ↑ "AANS Programme Guide 2011" American Association of Neurological Surgeons. Retrieved 2019-06-05.
  32. ↑ "The American Society for Clinical Investigation" (in en-US). https://www.the-asci.org/controllers/asci/AsciProfileController.php?pid=500987. 
  33. ↑ "Professor Richard Gilbertson | The Academy of Medical Sciences". https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Professor-Richard-Gilbertson-0023663. 
  34. ↑ "Richard Gilbertson". https://royalsociety.org/people/richard-gilbertson-35830/. 
  35. ↑ "Richard Gilbertson Named 2022 Society of Memorial Sloan Kettering Prize Recipient for Contributions in Pediatric Oncology | Memorial Sloan Kettering Cancer Center" (in en). https://www.mskcc.org/news/richard-gilbertson-named-2022-society-msk-prize-recipient-contributions-pediatric-oncology. 



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