Biology:POLDIP2
 Generic protein structure example |
Polymerase delta-interacting protein 2 also known as Polymerase delta-interacting protein of 38 kDa (PDIP38) is encoded by the POLDIP2 gene in humans.[1][2]
This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. The encoded protein also interacts with proliferating cell nuclear antigen. Some transcripts of this gene overlap in a tail-to-tail orientation with the gene for tumor necrosis factor, alpha-induced protein 1 (TNFAIP1).[2] POLDIP2 / PDIP38 is a moonlighting protein that has been identified in both the nucleus [3] and the mitochondrion [4][5]
Interactions
In the nucleus, POLDIP2 has been shown to interact with PCNA,[1] while in the mitochondrion POLDIP2 has been shown to interact with proteins constituting the mitochondrial DNA nucleoid [6] and the AAA+ protease CLPXP [5][7] where it modulates both the specificity and stability of this proteolytic machine.
References
- ↑ 1.0 1.1 "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". The Journal of Biological Chemistry 278 (12): 10041–7. March 2003. doi:10.1074/jbc.M208694200. PMID 12522211.
- ↑ 2.0 2.1 "Entrez Gene: POLDIP2 polymerase (DNA-directed), delta interacting protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26073.
- ↑ "PDIP38 is translocated to the spliceosomes/nuclear speckles in response to UV-induced DNA damage and is required for UV-induced alternative splicing of MDM2". Cell Cycle 12 (19): 3184–93. October 2013. doi:10.4161/cc.26221. PMID 23989611.
- ↑ "Further characterization of human DNA polymerase delta interacting protein 38". The Journal of Biological Chemistry 280 (23): 22375–84. June 2005. doi:10.1074/jbc.M414597200. PMID 15811854.
- ↑ 5.0 5.1 "Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA+ protease CLPXP". Communications Biology 3 (1): 646. November 2020. doi:10.1038/s42003-020-01358-6. PMID 33159171.
- ↑ "PDIP38 associates with proteins constituting the mitochondrial DNA nucleoid". Journal of Biochemistry 138 (6): 673–8. December 2005. doi:10.1093/jb/mvi169. PMID 16428295.
- ↑ "Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer". Proceedings of the National Academy of Sciences of the United States of America 115 (8): 1789–1794. February 2018. doi:10.1073/pnas.1720693115. PMID 29434038.
Further reading
- "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research 10 (10): 1546–60. October 2000. doi:10.1101/gr.140200. PMID 11042152.
- "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. November 2000. doi:10.1101/gr.143000. PMID 11076863.
- "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. September 2000. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. October 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "Further characterization of human DNA polymerase delta interacting protein 38". The Journal of Biological Chemistry 280 (23): 22375–84. June 2005. doi:10.1074/jbc.M414597200. PMID 15811854.
- "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. September 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415-8. January 2006. doi:10.1093/nar/gkj139. PMID 16381901.
- "The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38". The Journal of Biological Chemistry 282 (36): 26629–40. September 2007. doi:10.1074/jbc.M701807200. PMID 17623671.
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