Biology:Sodium-dependent multivitamin transporter
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Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene.[1][2][3]
The SMVT is a transporter for pantothenic acid (vitamin B5) and biotin (vitamin B7) at the blood–brain barrier.[4] It is also a transporter for alpha lipoic acid[5] and iodide. Transport of these nutrients is competitive[6] and a surplus of a given nutrient may saturate the transporter and prevent the uptake of other nutrients.
References
- ↑ "Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate". The Journal of Biological Chemistry 273 (13): 7501–6. March 1998. doi:10.1074/jbc.273.13.7501. PMID 9516450.
- ↑ "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization". The Journal of Biological Chemistry 274 (21): 14875–83. May 1999. doi:10.1074/jbc.274.21.14875. PMID 10329687.
- ↑ "Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8884.
- ↑ "Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells". Journal of Neurochemistry 134 (1): 97–112. July 2015. doi:10.1111/jnc.13092. PMID 25809983.
- ↑ "The sodium/multivitamin transporter: a multipotent system with therapeutic implications". Vitamins and Hormones 98: 63–100. 2015. doi:10.1016/bs.vh.2014.12.003. PMID 25817866.
- ↑ "High specificity in response of the sodium-dependent multivitamin transporter to derivatives of pantothenic acid". Current Topics in Medicinal Chemistry 13 (7): 837–42. 31 March 2013. doi:10.2174/1568026611313070006. PMID 23578027.
Further reading
- "Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter". Archives of Biochemistry and Biophysics 366 (1): 95–106. June 1999. doi:10.1006/abbi.1999.1213. PMID 10334869.
- "Proliferation of peripheral blood mononuclear cells causes increased expression of the sodium-dependent multivitamin transporter gene and increased uptake of pantothenic acidopen star". The Journal of Nutritional Biochemistry 12 (8): 465–473. August 2001. doi:10.1016/S0955-2863(01)00162-0. PMID 11834205.
- "Characterization of the 5' regulatory region of the human sodium-dependent multivitamin transporter, hSMVT". Biochimica et Biophysica Acta 1574 (2): 187–92. March 2002. doi:10.1016/s0167-4781(02)00226-9. PMID 11955628.
- "Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system". American Journal of Physiology. Gastrointestinal and Liver Physiology 285 (1): G73-7. July 2003. doi:10.1152/ajpgi.00059.2003. PMID 12646417.
- "Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects". American Journal of Physiology. Renal Physiology 288 (4): F823-31. April 2005. doi:10.1152/ajprenal.00375.2004. PMID 15561972.
- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research 12 (2): 117–26. 2007. doi:10.1093/dnares/12.2.117. PMID 16303743.
- "Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery". Molecular Pharmaceutics 3 (3): 329–39. 2006. doi:10.1021/mp0500768. PMID 16749865.
- "Molecular mechanisms involved in the adaptive regulation of human intestinal biotin uptake: A study of the hSMVT system". American Journal of Physiology. Gastrointestinal and Liver Physiology 292 (1): G275-81. January 2007. doi:10.1152/ajpgi.00327.2006. PMID 16959947.
- "Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo". American Journal of Physiology. Cell Physiology 292 (4): C1305-12. April 2007. doi:10.1152/ajpcell.00360.2006. PMID 17135299.
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