Biology:CBX2 (gene)
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Chromobox protein homolog 2 is a protein that in humans is encoded by the CBX2 gene.[1][2][3] According to a New Scientist article CBX2 controls human sex even more so than X/Y chromosomes.[4]
Interactions
CBX2 (gene) has been shown to interact with RYBP.[5] It also interacts with the testis determining factor encoded by the SRY gene on the Y chromosome, as both proteins are necessary components of the male cascade.
References
- ↑ "Assignment of a Polycomb-like chromobox gene (CBX2) to human chromosome 17q25". Genomics 26 (1): 130–3. Jul 1995. doi:10.1016/0888-7543(95)80091-Y. PMID 7782071.
- ↑ "Early detection and screening for prostatic cancer". Urology 34 (4 Suppl): 10–2; discussion 46–56. Nov 1989. doi:10.1016/0090-4295(89)90228-8. PMID 2477932.
- ↑ "Entrez Gene: CBX2 chromobox homolog 2 (Pc class homolog, Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84733.
- ↑ Ewen Callaway. "Girl with Y chromosome sheds light on maleness ", New Scientist, 2009-04-09. Retrieved on 2009-04-14.
- ↑ "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. Jun 1999. doi:10.1093/emboj/18.12.3404. PMID 10369680.
External links
- Human CBX2 genome location and CBX2 gene details page in the UCSC Genome Browser.
Further reading
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. 2004. doi:10.1038/nbt971. PMID 15146197.
- "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. 1999. doi:10.1093/emboj/18.12.3404. PMID 10369680.
- "Male-to-female sex reversal in M33 mutant mice". Nature 393 (6686): 688–92. 1998. doi:10.1038/31482. PMID 9641679. Bibcode: 1998Natur.393..688K.
- "The mouse has a Polycomb-like chromobox gene". Development 114 (4): 921–9. 1992. doi:10.1242/dev.114.4.921. PMID 1352241.
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