Biology:Fcab
From HandWiki
Short description: Antibodies fragments
Fcabs are antibodies fragments engineered from the constant region of an antibody (Fc).[1] In naturally occurring antibodies (such as IgGs), the antigen-binding sites are located at the variable regions (Fab).
Overview
Fcabs can be expressed as soluble proteins or they can be engineered back into a full IgG. This type of antibodies are therefore able to recognise two different antigens, one at their Fab region and a second one at the Fc region, hence the name of bispecific antibodies. This antibody fragment is part of the modular antibody technology of F-star Biotechnology Ltd.[citation needed]
See also
- Antibody Fragments
- Monoclonal antibodies
References
- ↑ "Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties.". Protein Eng Des 23 (4): 289–297. 2010. doi:10.1093/protein/gzq005. PMID 20150180.
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