Biology:SDK2
 Generic protein structure example |
Protein sidekick-2 is a protein that in humans is encoded by the SDK2 gene.[1][2][3][4]
Function
The protein encoded by this gene is a member of the immunoglobulin superfamily.[3] The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined.[4]
References
- ↑ "OMIM: SIDEKICK CELL ADHESION MOLECULE 2; SDK2". https://www.omim.org/entry/607217.
- ↑ "Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina". Cell 110 (5): 649–60. Sep 2002. doi:10.1016/S0092-8674(02)00910-8. PMID 12230981.
- ↑ 3.0 3.1 Yamagata, M. (2020). "Structure and Functions of Sidekicks". Frontiers in Molecular Neuroscience 13: 139. doi:10.3389/fnmol.2020.00139. PMID 32982686.
- ↑ 4.0 4.1 "Entrez Gene: SDK2 sidekick homolog 2 (chicken)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54549.
Further reading
- "Structure and Functions of Sidekicks". Frontiers in Molecular Neuroscience 13: 139. 2020. doi:10.3389/fnmol.2020.00139. PMID 32982686.
- "Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy". J Am Soc Nephrol 15 (7): 1721–30. Jun 2004. doi:10.1097/01.ASN.0000128975.28958.C2. PMID 15213259.
- "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature 440 (7087): 1045–9. 2006. doi:10.1038/nature04689. PMID 16625196. Bibcode: 2006Natur.440.1045Z.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. 2000. doi:10.1093/dnares/7.2.143. PMID 10819331.
- "The sidekick gene, a member of the immunoglobulin superfamily, is required for pattern formation in the Drosophila eye". Development 124 (17): 3303–12. 1997. doi:10.1242/dev.124.17.3303. PMID 9310325.
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