Biology:NECAB3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.[1][2]
The protein encoded by this gene interacts with the amino-terminal domain of the amyloid beta A4 precursor protein-binding family A member 2 (APBA2), inhibits the association of APBA2 with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by APBA2. This protein, together with APBA2, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.[2]
See also
- N-terminal
- EF-hand
References
- ↑ "Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein". J Biol Chem 275 (30): 23134–8. Aug 2000. doi:10.1074/jbc.C000302200. PMID 10833507.
- ↑ 2.0 2.1 "Entrez Gene: APBA2BP amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63941.
External links
- Human NECAB3 genome location and NECAB3 gene details page in the UCSC Genome Browser.
Further reading
- "A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library.". Nucleic Acids Res. 26 (21): 5007–8. 1998. doi:10.1093/nar/26.21.5007. PMID 9776767.
- "Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins.". Biochemistry 39 (11): 2940–9. 2000. doi:10.1021/bi9920984. PMID 10715114.
- "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
- "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern.". Neuroscience 112 (1): 51–63. 2002. doi:10.1016/S0306-4522(02)00063-5. PMID 12044471.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms.". Biochem. J. 374 (Pt 1): 261–8. 2003. doi:10.1042/BJ20030489. PMID 12780348.
- "NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi.". Exp. Cell Res. 292 (2): 393–402. 2004. doi:10.1016/j.yexcr.2003.09.025. PMID 14697346.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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