Biology:CGB2 (gene)
Generic protein structure example |
Choriogonadotropin subunit beta variant 2 is a protein that in humans is encoded by the CGB2 gene.[1][2]
The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits.[3] However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits.[2]
References
- ↑ "The beta subunit of human chorionic gonadotropin is encoded by multiple genes". J Biol Chem 258 (19): 11492–9. Nov 1983. doi:10.1016/S0021-9258(17)44254-2. PMID 6194155.
- ↑ 2.0 2.1 "Entrez Gene: CGB2 chorionic gonadotropin, beta polypeptide 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114336.
- ↑ "Expression of the human chorionic gonadotropin-beta gene cluster in human pituitaries and alternate use of exon 1". J. Clin. Endocrinol. Metab. 81 (12): 4212–7. December 1996. doi:10.1210/jcem.81.12.8954017. PMID 8954017.
External links
- Human CGB2 genome location and CGB2 gene details page in the UCSC Genome Browser.
Further reading
- "Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo". J. Biol. Chem. 267 (5): 3179–84. 1992. doi:10.1016/S0021-9258(19)50712-8. PMID 1371113.
- "A map of the hCG beta-LH beta gene cluster". J. Biol. Chem. 261 (13): 5907–16. 1986. doi:10.1016/S0021-9258(17)38469-7. PMID 2422163.
- Julier C; Weil D; Couillin P et al. (1984). "The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19". Hum. Genet. 67 (2): 174–177. doi:10.1007/BF00272995. PMID 6204923.
- "The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone". DNA 2 (4): 281–289. 1984. doi:10.1089/dna.1983.2.281. PMID 6319099.
- "Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone". Nature 307 (5946): 37–40. 1984. doi:10.1038/307037a0. PMID 6690982.
- Dirnhofer S; Hermann M; Hittmair A et al. (1997). "Expression of the human chorionic gonadotropin-beta gene cluster in human pituitaries and alternate use of exon 1". J. Clin. Endocrinol. Metab. 81 (12): 4212–4217. doi:10.1210/jcem.81.12.8954017. PMID 8954017.
- Venter JC; Adams MD; Myers EW et al. (2001). "The sequence of the human genome". Science 291 (5507): 1304–1351. doi:10.1126/science.1058040. PMID 11181995.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The evolution and genomic landscape of CGB1 and CGB2 genes". Mol. Cell. Endocrinol. 260–262: 2–11. 2007. doi:10.1016/j.mce.2005.11.049. PMID 17055150.