Biology:Anion exchange protein 3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Anion exchange protein 3 is a membrane transport protein that in humans is encoded by the SLC4A3 gene.[1][2] AE3 is functionally similar to the Band 3 Cl−/HCO3− exchange protein but it is expressed primarily in brain neurons and in the heart. Like AE2 its activity is sensitive to pH.[3][4] AE3 mutations have been linked to seizures.[5][6]
See also
References
- ↑ "Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36". Genomics 22 (3): 605–9. Jan 1995. doi:10.1006/geno.1994.1433. PMID 8001971.
- ↑ "Entrez Gene: SLC4A3 solute carrier family 4, anion exchanger, member 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6508.
- ↑ "Bicarbonate homeostasis in excitable tissues: role of AE3 Cl-/HCO3- exchanger and carbonic anhydrase XIV interaction". Am. J. Physiol., Cell Physiol. 297 (5): C1091–102. November 2009. doi:10.1152/ajpcell.00177.2009. PMID 19692653.
- ↑ "Regulation of intestinal Cl-/HCO3- exchanger SLC26A3 by intracellular pH". Am. J. Physiol., Cell Physiol. 296 (6): C1279–90. June 2009. doi:10.1152/ajpcell.00638.2008. PMID 19321737.
- ↑ "Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold". Mol. Cell. Biol. 26 (1): 182–91. January 2006. doi:10.1128/MCB.26.1.182-191.2006. PMID 16354689.
- ↑ "Characterization of an epilepsy-associated variant of the human Cl-/HCO3(-) exchanger AE3". Am. J. Physiol., Cell Physiol. 297 (3): C526–36. September 2009. doi:10.1152/ajpcell.00572.2008. PMID 19605733.
Further reading
- "The AE gene family of Cl/HCO3- exchangers.". J. Nephrol.. 15 Suppl 5: S41–53. 2002. PMID 12027221.
- "Regulation of intracellular pH by a neuronal homolog of the erythrocyte anion exchanger.". Cell 59 (5): 927–37. 1990. doi:10.1016/0092-8674(89)90615-6. PMID 2686841.
- "Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart.". Circ. Res. 75 (4): 603–14. 1994. doi:10.1161/01.res.75.4.603. PMID 7923606.
- "Association of the brain anion exchanger, AE3, with the repeat domain of ankyrin.". J. Cell Sci.. 105 ( Pt 4) (4): 1137–42. 1993. doi:10.1242/jcs.105.4.1137. PMID 8227202.
- "Expression of the Na+/H+ and Cl-/HCO-3 exchanger isoforms in proximal and distal human airways.". Am. J. Physiol. 276 (6 Pt 1): L971–8. 1999. doi:10.1152/ajplung.1999.276.6.L971. PMID 10362722.
- "Genomic structure of human anion exchanger 3 and its potential role in hereditary neurological disease.". Neurogenetics 1 (4): 289–92. 2000. doi:10.1007/s100480050043. PMID 10732805.
- "Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex.". Am. J. Physiol. Renal Physiol. 280 (2): F356–64. 2001. doi:10.1152/ajprenal.2001.280.2.f356. PMID 11208611.
- "Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization.". Biochim. Biophys. Acta 1511 (1): 17–27. 2001. doi:10.1016/S0005-2736(00)00366-7. PMID 11248201.
- "A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers.". J. Biol. Chem. 276 (51): 47886–94. 2002. doi:10.1074/jbc.M105959200. PMID 11606574.
- "Molecular basis for angiotensin II-induced increase of chloride/bicarbonate exchange in the myocardium.". Circ. Res. 89 (12): 1246–53. 2002. doi:10.1161/hh2401.101907. PMID 11739292.
- "Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine.". Am. J. Physiol. Gastrointest. Liver Physiol. 282 (3): G573–9. 2002. doi:10.1152/ajpgi.00338.2001. PMID 11842009.
- "The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV.". J. Biol. Chem. 277 (28): 25239–46. 2002. doi:10.1074/jbc.M202562200. PMID 11994299.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
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