Biology:COP9 signalosome complex subunit 3
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COP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene.[1][2][3] It encodes a subunit of the COP9 signalosome.
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.[3]
See also
References
- ↑ "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J 12 (6): 469–78. Apr 1998. doi:10.1096/fasebj.12.6.469. PMID 9535219.
- ↑ "Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2". Genomics 57 (1): 180–2. Jun 1999. doi:10.1006/geno.1998.5748. PMID 10191102.
- ↑ 3.0 3.1 "Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8533.
External links
- Human COPS3 genome location and COPS3 gene details page in the UCSC Genome Browser.
- Human CSN3 genome location and CSN3 gene details page in the UCSC Genome Browser.
Further reading
- "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. 2004. doi:10.1038/ncb1203-1029. PMID 14647295.
- "Amplification and overexpression of genes in 17p11.2 ~ p12 in osteosarcoma.". Cancer Genet. Cytogenet. 153 (1): 77–80. 2004. doi:10.1016/j.cancergencyto.2004.03.007. PMID 15325100.
- "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex.". Curr. Biol. 8 (16): 919–22. 1998. doi:10.1016/S0960-9822(07)00372-7. PMID 9707402.
- "Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity.". Nature 404 (6778): 617–21. 2000. doi:10.1038/35007098. PMID 10766246. Bibcode: 2000Natur.404..617B.
- "The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain.". J. Mol. Biol. 305 (1): 1–9. 2001. doi:10.1006/jmbi.2000.4288. PMID 11114242.
- "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. 2001. doi:10.1093/emboj/20.7.1630. PMID 11285227.
- "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science 292 (5520): 1382–5. 2001. doi:10.1126/science.1059780. PMID 11337588. Bibcode: 2001Sci...292.1382L.
- "CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation". FEBS Lett. 499 (1–2): 133–6. 2001. doi:10.1016/S0014-5793(01)02535-2. PMID 11418127.
- "Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse". Genome Res. 12 (5): 713–28. 2002. doi:10.1101/gr.73702. PMID 11997338.
- "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. 2002. doi:10.1016/S0014-5793(02)03147-2. PMID 12220626.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell Sci. 116 (Pt 3): 453–61. 2003. doi:10.1242/jcs.00243. PMID 12508107.
- "Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex". Plant Cell 15 (3): 719–31. 2003. doi:10.1105/tpc.009092. PMID 12615944.
- "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics 81 (2): 112–25. 2003. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
- "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–12. 2003. doi:10.1093/emboj/cdg127. PMID 12628923.
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. 2004. doi:10.1038/nbt810. PMID 12665801.
- "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell 113 (3): 357–67. 2003. doi:10.1016/S0092-8674(03)00316-7. PMID 12732143.
- "Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation". Oncogene 22 (34): 5358–61. 2003. doi:10.1038/sj.onc.1206671. PMID 12917637.
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