Biology:PRKX

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Protein kinase, X-linked is a protein that in humans is encoded by the PRKX gene.

Function

This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y.

Further reading

• "PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9260–5. 2002. doi:10.1073/pnas.132051799. PMID 12082174. Bibcode: 2002PNAS...99.9260L. 
• "Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency". Biochim. Biophys. Acta 1782 (1): 1–9. 2008. doi:10.1016/j.bbadis.2007.09.003. PMID 17980165. https://hal.archives-ouvertes.fr/hal-00562802/file/PEER_stage2_10.1016%252Fj.bbadis.2007.09.003.pdf. 
• "PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation". Dev. Biol. 356 (2): 475–85. 2011. doi:10.1016/j.ydbio.2011.05.673. PMID 21684272. 
• "MBD 4--a potential substrate for protein kinase X". Acta Biochim. Biophys. Sin. (Shanghai) 43 (11): 916–7. 2011. doi:10.1093/abbs/gmr086. PMID 21971312. 
• "PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell lines". Int. J. Cancer 131 (2): E45–55. 2012. doi:10.1002/ijc.26486. PMID 22020623. 
• "PRKX, a Novel cAMP-Dependent Protein Kinase Member, Plays an Important Role in Development". J. Cell. Biochem. 117 (3): 566–73. 2016. doi:10.1002/jcb.25304. PMID 26252946. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.