Biology:KLC3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Kinesin light chain 3 is a protein that in humans is encoded by the KLC3 gene.

Function

This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.

Interactions

KLC3 has been shown to interact with YWHAH.

Further reading

• "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931. 
• "Rat kinesin light chain 3 associates with spermatid mitochondria". Developmental Biology 275 (1): 23–33. Nov 2004. doi:10.1016/j.ydbio.2004.07.014. PMID 15464570. 
• "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology 14 (16): 1436–50. Aug 2004. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
• "Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion". The Journal of Biological Chemistry 278 (18): 16159–68. May 2003. doi:10.1074/jbc.M213126200. PMID 12594206. 
• "Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet". The Journal of Cell Biology 159 (3): 431–40. Nov 2002. doi:10.1083/jcb.200207153. PMID 12427867. 
• "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry 41 (17): 5566–72. Apr 2002. doi:10.1021/bi015946f. PMID 11969417. 
• "Kinesin light-chain KLC3 expression in testis is restricted to spermatids". Biology of Reproduction 64 (5): 1320–30. May 2001. doi:10.1095/biolreprod64.5.1320. PMID 11319135. 
• "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". The Journal of Cell Biology 146 (6): 1277–88. Sep 1999. doi:10.1083/jcb.146.6.1277. PMID 10491391. 
• "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". The Journal of Biological Chemistry 273 (25): 15395–403. Jun 1998. doi:10.1074/jbc.273.25.15395. PMID 9624122. 
• "Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes". Genomics 34 (3): 399–409. Jun 1996. doi:10.1006/geno.1996.0303. PMID 8786141. https://zenodo.org/record/1229683.