Biology:EBI3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the EBI3 gene.[1][2]
Function
This gene was identified by the induction of its expression in B lymphocytes by Epstein–Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It plays a role in regulating cell-mediated immune responses.[3]
EBI3 is a subunit in 2 distinct heterodimeric cytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and EBI3. IL27 can trigger signaling in T cells, B cells, and myeloid cells.[4] IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of IL12.[3][5]
References
- ↑ "Entrez Gene: EBI3 Epstein-Barr virus induced gene 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10148.
- ↑ "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. February 1996. doi:10.1128/JVI.70.2.1143-1153.1996. PMID 8551575.
- ↑ 3.0 3.1 "The inhibitory cytokine IL-35 contributes to regulatory T-cell function". Nature 450 (7169): 566–9. November 2007. doi:10.1038/nature06306. PMID 18033300. Bibcode: 2007Natur.450..566C.
- ↑ "Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells". Nat. Immunol. 7 (9): 929–36. September 2006. doi:10.1038/ni1375. PMID 16906167.
- ↑ "IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells". Eur. J. Immunol. 37 (11): 3021–9. November 2007. doi:10.1002/eji.200737810. PMID 17874423.
Further reading
- Small RD (1976). "Letter: Statistical analysis of respiratory sensitivity to CO2.". N. Engl. J. Med. 295 (7): 397. doi:10.1056/NEJM197608122950720. PMID 934235.
- "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes.". J. Virol. 70 (2): 1143–53. 1996. doi:10.1128/JVI.70.2.1143-1153.1996. PMID 8551575.
- "Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin.". Proc. Natl. Acad. Sci. U.S.A. 94 (22): 12041–6. 1997. doi:10.1073/pnas.94.22.12041. PMID 9342359. Bibcode: 1997PNAS...9412041D.
- "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells.". Immunity 16 (6): 779–90. 2002. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Expression of IL-27 in human Th1-associated granulomatous diseases.". J. Pathol. 202 (2): 164–71. 2004. doi:10.1002/path.1508. PMID 14743498.
- "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. 2004. doi:10.1038/nature02399. PMID 15057824. Bibcode: 2004Natur.428..529G.
- "Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease.". J. Med. Virol. 73 (3): 432–8. 2004. doi:10.1002/jmv.20109. PMID 15170639.
- "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
External links
- EBI3 human gene location in the UCSC Genome Browser.
- EBI3 human gene details in the UCSC Genome Browser.
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