Biology:MYH14
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Myosin-14 is a protein that in humans is encoded by the MYH14 gene.[1][2][3]
This gene encodes a member of the myosin superfamily. Myosins are actin-dependent motor proteins with diverse functions, including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene.[3]
References
- ↑ "A novel myosin heavy chain gene in human chromosome 19q13.3". Gene 312: 165–71. Aug 2003. doi:10.1016/S0378-1119(03)00613-9. PMID 12909352.
- ↑ "Nonmuscle Myosin Heavy-Chain Gene MYH14 Is Expressed in Cochlea and Mutated in Patients Affected by Autosomal Dominant Hearing Impairment (DFNA4)". Am J Hum Genet 74 (4): 770–6. Mar 2004. doi:10.1086/383285. PMID 15015131.
- ↑ 3.0 3.1 "Entrez Gene: MYH14 myosin, heavy chain 14". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79784.
Further reading
- "Linkage of a gene for dominant non-syndromic deafness to chromosome 19". Hum. Mol. Genet. 4 (6): 1073–6. 1995. doi:10.1093/hmg/4.6.1073. PMID 7655461.
- "Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin". Am. J. Pathol. 142 (1): 221–30. 1993. PMID 8424456.
- "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. 2002. doi:10.1073/pnas.241522398. PMID 11752456.
- "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family". Mol. Biol. Evol. 19 (4): 375–93. 2002. doi:10.1093/oxfordjournals.molbev.a004093. PMID 11919279.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family". J. Biol. Chem. 279 (4): 2800–8. 2004. doi:10.1074/jbc.M309981200. PMID 14594953.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. 2004. doi:10.1038/ncb1086. PMID 14743216.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. 2004. doi:10.1073/pnas.0404089101. PMID 15498874. Bibcode: 2004PNAS..10115724W.
- "Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C". J. Biol. Chem. 280 (24): 22769–75. 2005. doi:10.1074/jbc.M503488200. PMID 15845534.
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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