Biology:BCAS1
 Generic protein structure example |
Breast carcinoma-amplified sequence 1 is a protein that in humans is encoded by the BCAS1 gene.[1][2]
Breast carcinoma amplified sequence 1 (BCAS1) was isolated from a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, BCAS1 was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, the BCAS1 gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, BCAS1 is a candidate oncogene. It is predicted to encode a protein of 584 amino acids with no significant homology to other proteins.[2]
References
- ↑ "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma". Proc Natl Acad Sci U S A 95 (15): 8703–8. Aug 1998. doi:10.1073/pnas.95.15.8703. PMID 9671742. Bibcode: 1998PNAS...95.8703C.
- ↑ 2.0 2.1 "Entrez Gene: BCAS1 breast carcinoma amplified sequence 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8537.
External links
- Human BCAS1 genome location and BCAS1 gene details page in the UCSC Genome Browser.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer". Cancer Res. 56 (15): 3441–5. 1996. PMID 8758909.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "NABC1 (BCAS1): alternative splicing and downregulation in colorectal tumors". Genomics 65 (3): 299–302. 2000. doi:10.1006/geno.2000.6172. PMID 10857754.
- "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". J. Biol. Chem. 276 (17): 14059–66. 2001. doi:10.1074/jbc.M010320200. PMID 11148209.
- "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Characterization of the novel amplified in breast cancer-1 (NABC1) gene product". Exp. Cell Res. 290 (2): 402–13. 2003. doi:10.1016/S0014-4827(03)00353-7. PMID 14567997.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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