Biology:RNR5

Short description: Gene in the species Homo sapiens

Generic protein structure example

RNA, ribosomal 5, also known as RNR5, is a human gene. Genes for ribosomal RNA are clustered on the short arms of chromosomes 13, 14, 15, 20, 21. The gene for RNR5 exists in multiple copies on chromosome 22. Each gene cluster contains 30–40 copies and encodes a 45S RNA product that is then cleaved to form 18S, 5.8S and 28S rRNA subunits. In general, genes for RNA remain poorly annotated in most large public databases.

Further reading

• Nucleolus organizer regions are chromosomal regions crucial for the formation of the nucleolus, located on the short arms of the acrocentric chromosomes 13, 14, 15, 21 and 22
• "Identification of p53 as a sequence-specific DNA-binding protein.". Science 252 (5013): 1708–1711. 1991. doi:10.1126/science.2047879. PMID 2047879. Bibcode: 1991Sci...252.1708K. 
• "Sequence and structure correlation of human ribosomal transcribed spacers.". J. Mol. Biol. 212 (1): 27–35. 1990. doi:10.1016/0022-2836(90)90302-3. PMID 2319598. 
• "Human ribosomal DNA: novel sequence organization in a 4.5-kb region upstream from the promoter.". Gene 84 (1): 193–196. 1990. doi:10.1016/0378-1119(89)90155-8. PMID 2606358. 
• "Molecular analysis of the heterogeneity region of the human ribosomal spacer.". J. Mol. Biol. 183 (2): 213–223. 1985. doi:10.1016/0022-2836(85)90214-1. PMID 2989541. 
• "Evolutionary changes of sequences and factors that direct transcription termination of human and mouse ribsomal genes". Mol. Cell. Biol. 7 (7): 2521–2529. 1987. doi:10.1128/mcb.7.7.2521. PMID 3649563. 
• "Two distinct promoter elements in the human rRNA gene identified by linker scanning mutagenesis". Mol. Cell. Biol. 6 (1): 227–235. 1987. doi:10.1128/mcb.6.1.227. PMID 3785147. 
• "Variation among human 28S ribosomal RNA genes". Proc. Natl. Acad. Sci. U.S.A. 82 (22): 7666–7670. 1985. doi:10.1073/pnas.82.22.7666. PMID 3865188. Bibcode: 1985PNAS...82.7666G. 
• "Human 18 S ribosomal RNA sequence inferred from DNA sequence. Variations in 18 S sequences and secondary modification patterns between vertebrates". Biochem. J. 232 (3): 725–733. 1986. doi:10.1042/bj2320725. PMID 4091818. 
• "Human ribosomal RNA gene: nucleotide sequence of the transcription initiation region and comparison of three mammalian genes". Proc. Natl. Acad. Sci. U.S.A. 79 (10): 3092–3096. 1982. doi:10.1073/pnas.79.10.3092. PMID 6954460. Bibcode: 1982PNAS...79.3092F. 
• "Complete sequence of the 43-kb human ribosomal DNA repeat: analysis of the intergenic spacer". Genomics 27 (2): 320–328. 1995. doi:10.1006/geno.1995.1049. PMID 7557999. 
• "Human rDNA: evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes". Genomics 73 (3): 255–263. 2001. doi:10.1006/geno.2001.6540. PMID 11350117.