Biology:FBXW10
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F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.[1][2][3]
Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM][3] Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1, ATR kinases (Chaturvedi and ParnaiK, 2010, PMID: 20498703).
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References
- ↑ "Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat". Genomics 53 (1): 110–2. Dec 1998. doi:10.1006/geno.1998.5453. PMID 9787083.
- ↑ "Single test for two hereditary neuropathies, CMT1A and HNPP". Clin Chem 41 (10): 1534–5. Dec 1995. doi:10.1093/clinchem/41.10.1534. PMID 7586531.
- ↑ 3.0 3.1 "Entrez Gene: FBXW10 F-box and WD repeat domain containing 10". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10517.
Further reading
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Systematic analysis and nomenclature of mammalian F-box proteins.". Genes Dev. 18 (21): 2573–80. 2005. doi:10.1101/gad.1255304. PMID 15520277.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
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