Biography:Jacqueline Lees
Jacqueline A. Lees | |
|---|---|
| Alma mater | University of York University of London |
| Scientific career | |
| Fields | Biochemistry, cancer biology |
| Institutions | Koch Institute for Integrative Cancer Research, MIT |
Jacqueline A. Lees is a British biochemist.
Lees is the Virginia and D.K. Ludwig Professor for Cancer Research and associate director of the Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology.[1] She received her BSc degree from the University of York in 1986, and her PhD from the University of London in 1990, both in biochemistry.[2] She was a postdoc in the laboratory of Ed Harlow, first at Cold Spring Harbor and then at Massachusetts General Hospital, before joining the faculty at MIT in 1994.[3]
Research
Lees’ research is focused on identifying the proteins and pathways that play a key role in tumorigenicity and establishing the mechanism of their action in both normal and tumor cells.[1] Her lab at MIT uses a combination of molecular and cellular analyses and mutant mouse models. She is also known for her work with Nancy Hopkins on genetic screens in zebrafish.[4] Lees studies how the E2F family of mammalian transcription factors contributes to the regulation of cellular proliferation during normal development and tumorigenesis.[1] Her work has shown that certain E2Fs, despite substantial biochemical similarities, play radically different biological roles.[5]
References
- ↑ 1.0 1.1 1.2 "The Koch Institute: Jacqueline A. Lees". https://ki.mit.edu/people/faculty/lees.
- ↑ "Corporation awards tenure to 23 faculty members". 17 October 2001. http://news.mit.edu/2001/tenure-1017.
- ↑ "Sizer CD Chair is established". May 1996. http://news.mit.edu/1996/sizer-0501.
- ↑ Zhang, GuangJun; Hoersch, Sebastian; Amsterdam, Adam; Whittaker, Charles A.; Lees, Jacqueline A.; Hopkins, Nancy (2010-09-28). "Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers" (in en). Proceedings of the National Academy of Sciences 107 (39): 16940–16945. doi:10.1073/pnas.1011548107. ISSN 0027-8424. PMID 20837522. Bibcode: 2010PNAS..10716940Z.
- ↑ Iaquinta, Phillip J; Lees, Jacqueline A (2007-12-01). "Life and death decisions by the E2F transcription factors" (in en). Current Opinion in Cell Biology. Cell differentiation / Cell division, growth and death 19 (6): 649–657. doi:10.1016/j.ceb.2007.10.006. ISSN 0955-0674. PMID 18032011.
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