Biology:UBE2H

Generic protein structure example

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

Further reading

• "Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation.". Proc. Natl. Acad. Sci. U.S.A. 92 (11): 4982–6. 1995. doi:10.1073/pnas.92.11.4982. PMID 7761435. Bibcode: 1995PNAS...92.4982W. 
• "Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2.". FEBS Lett. 377 (2): 193–6. 1996. doi:10.1016/0014-5793(95)01323-7. PMID 8543049. 
• "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32.". Genomics 66 (2): 221–5. 2000. doi:10.1006/geno.2000.6206. PMID 10860668. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. 2003. doi:10.1126/science.1083423. PMID 12690205. Bibcode: 2003Sci...300..767S. 
• "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. 2003. doi:10.1038/nature01782. PMID 12853948. Bibcode: 2003Natur.424..157H. 
• "Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder.". Psychiatr. Genet. 13 (4): 221–5. 2005. doi:10.1097/00041444-200312000-00005. PMID 14639049. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins.". J. Virol. 78 (3): 1109–20. 2004. doi:10.1128/JVI.78.3.1109-1120.2004. PMID 14722266. 
• "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.". Nat. Immunol. 5 (5): 495–502. 2004. doi:10.1038/ni1066. PMID 15107846. 
• "Identification of cyclophilin A as a CD99-binding protein by yeast two-hybrid screening.". Immunol. Lett. 95 (2): 155–9. 2005. doi:10.1016/j.imlet.2004.07.001. PMID 15388255. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.