Biology:MAPRE2
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 Generic protein structure example |
Microtubule-associated protein RP/EB family member 2 is a protein that in humans is encoded by the MAPRE2 gene.[1][2][3]
Function
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.[3]
Interactions
MAPRE2 has been shown to interact with APC.[4][5]
References
- ↑ "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells". J Immunol 159 (3): 1276–83. Aug 1997. PMID 9233623.
- ↑ "EB1 targets to kinetochores with attached, polymerizing microtubules". Mol Biol Cell 13 (12): 4308–16. Dec 2002. doi:10.1091/mbc.E02-04-0236. PMID 12475954.
- ↑ 3.0 3.1 "Entrez Gene: MAPRE2 microtubule-associated protein, RP/EB family, member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10982.
- ↑ "APC binds to the novel protein EB1". Cancer Res. 55 (14): 2972–7. Jul 1995. PMID 7606712.
- ↑ "Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization". Curr. Biol. 11 (13): 1062–7. Jul 2001. doi:10.1016/S0960-9822(01)00297-4. PMID 11470413.
Further reading
- "EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability". J. Cell Biol. 149 (4): 761–6. 2000. doi:10.1083/jcb.149.4.761. PMID 10811817.
- "APC binds to the novel protein EB1". Cancer Res. 55 (14): 2972–7. 1995. PMID 7606712.
- "The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10596–601. 1998. doi:10.1073/pnas.95.18.10596. PMID 9724749. Bibcode: 1998PNAS...9510596B.
- "EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle". Oncogene 17 (26): 3471–7. 1999. doi:10.1038/sj.onc.1202247. PMID 10030671.
- "EB/RP gene family encodes tubulin binding proteins". Int. J. Cancer 81 (2): 275–84. 1999. doi:10.1002/(SICI)1097-0215(19990412)81:2<275::AID-IJC18>3.0.CO;2-Z. PMID 10188731.
- "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- "Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization". Curr. Biol. 11 (13): 1062–7. 2001. doi:10.1016/S0960-9822(01)00297-4. PMID 11470413.
- "Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome". Mol. Biol. Cell 13 (10): 3627–45. 2003. doi:10.1091/mbc.E02-01-0061. PMID 12388762.
- "Characterization of functional domains of human EB1 family proteins". J. Biol. Chem. 278 (50): 49721–31. 2004. doi:10.1074/jbc.M306194200. PMID 14514668.
- "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. 2005. doi:10.1038/nbt1046. PMID 15592455.
- "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex". J. Cell Biol. 168 (1): 141–53. 2005. doi:10.1083/jcb.200405094. PMID 15631994.
- "A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin". BMC Cell Biol. 6 (1): 23. 2006. doi:10.1186/1471-2121-6-23. PMID 15862129.
- "Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway". Oncogene 24 (44): 6637–45. 2005. doi:10.1038/sj.onc.1208819. PMID 16007168.
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