Biology:PON3
From HandWiki
 Generic protein structure example |
Paraoxonase 3, also known as PON3, is a protein which in humans is encoded by the PON3 gene.[1][2]
Function
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.[2]
References
- ↑ "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics 33 (3): 498–507. May 1996. doi:10.1006/geno.1996.0225. PMID 8661009.
- ↑ 2.0 2.1 "Entrez Gene: PON3 paraoxonase 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5446.
Further reading
- "The paraoxonase gene family and coronary heart disease.". Curr. Opin. Lipidol. 13 (4): 357–62. 2003. doi:10.1097/00041433-200208000-00002. PMID 12151850.
- "The paraoxonase gene family and atherosclerosis.". Free Radic. Biol. Med. 38 (2): 153–63. 2005. doi:10.1016/j.freeradbiomed.2004.09.035. PMID 15607899.
- "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family.". Genomics 33 (3): 498–507. 1996. doi:10.1006/geno.1996.0225. PMID 8661009.
- La Du BN (2001). "Is paraoxonase-3 another hdl-associated protein protective against atherosclerosis?". Arterioscler. Thromb. Vasc. Biol. 21 (4): 467–8. doi:10.1161/01.ATV.21.4.467. PMID 11304457.
- "Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids.". Arterioscler. Thromb. Vasc. Biol. 21 (4): 542–7. 2001. doi:10.1161/01.ATV.21.4.542. PMID 11304470.
- "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. 2002. doi:10.1073/pnas.241522398. PMID 11752456. Bibcode: 2001PNAS...9815089X.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. 2003. doi:10.1126/science.1083423. PMID 12690205. Bibcode: 2003Sci...300..767S.
- "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. 2003. doi:10.1038/nature01782. PMID 12853948. Bibcode: 2003Natur.424..157H.
- "Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization.". Proc. Natl. Acad. Sci. U.S.A. 101 (2): 482–7. 2004. doi:10.1073/pnas.2536901100. PMID 14695884. Bibcode: 2004PNAS..101..482A.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.". Genomics 83 (4): 566–71. 2004. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities.". J. Lipid Res. 46 (6): 1239–47. 2005. doi:10.1194/jlr.M400511-JLR200. PMID 15772423.
- "Paraoxonases (PONs) 1, 2, and 3 are expressed in human and mouse gastrointestinal tract and in Caco-2 cell line: selective secretion of PON1 and PON2.". Free Radic. Biol. Med. 39 (3): 336–44. 2005. doi:10.1016/j.freeradbiomed.2005.03.016. PMID 15993332.
- "Cloning, high level expression of human paraoxonase-3 in Sf9 cells and pharmacological characterization of its product.". Biochem. Pharmacol. 70 (7): 1019–25. 2005. doi:10.1016/j.bcp.2005.07.004. PMID 16099434.
- "Cloning, purification, and refolding of human paraoxonase-3 expressed in Escherichia coli and its characterization.". Protein Expr. Purif. 46 (1): 92–9. 2006. doi:10.1016/j.pep.2005.07.021. PMID 16139510.
- "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. 2006. doi:10.1021/pr0502065. PMID 16335952.
 |
