Biology:ITM2B
From HandWiki
 Generic protein structure example |
Integral membrane protein 2B (ITM2B or BRI2) is a protein that in humans is encoded by the ITM2B gene.[1][2]
ITM2B or BRI2 is a gene located on chromosome 13. The gene is connected to familial Danish dementia and familial British dementia causing amyloid and pre-filbrillar effects similar to those seen in Alzheimer's.
References
- ↑ "cDNA sequence analysis, chromosomal assignment and expression pattern of the gene coding for integral membrane protein 2B". Gene 217 (1–2): 141–9. Nov 1998. doi:10.1016/S0378-1119(98)00354-0. PMID 9795190.
- ↑ "Entrez Gene: ITM2B integral membrane protein 2B". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9445.
Further reading
- "Chromosome 13 dementias.". Cell. Mol. Life Sci. 62 (16): 1814–25. 2005. doi:10.1007/s00018-005-5092-5. PMID 15968464.
- "Luria testing in demented patients.". Acta Neurol. Scand. 46 (S43): Suppl 43:97–8. 1970. doi:10.1111/j.1600-0447.1970.tb01106.x. PMID 5466275.
- "A stop-codon mutation in the BRI gene associated with familial British dementia.". Nature 399 (6738): 776–81. 1999. doi:10.1038/21637. PMID 10391242. Bibcode: 1999Natur.399..776V.
- "A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4920–5. 2000. doi:10.1073/pnas.080076097. PMID 10781099.
- "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. 2000. doi:10.1073/pnas.160270997. PMID 10931946. Bibcode: 2000PNAS...97.9543H.
- "Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2.". Oncogene 21 (20): 3181–9. 2002. doi:10.1038/sj.onc.1205464. PMID 12082633.
- "Properties of neurotoxic peptides related to the BRI gene.". Biochem. Soc. Trans. 30 (4): 557–9. 2003. doi:10.1042/BST0300557. PMID 12196136.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain.". Acta Neuropathol. 107 (1): 53–8. 2004. doi:10.1007/s00401-003-0783-1. PMID 14586629.
- "Axonal transport of British and Danish amyloid peptides via secretory vesicles.". FASEB J. 18 (2): 373–5. 2004. doi:10.1096/fj.03-0730fje. PMID 14656991.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production.". J. Biol. Chem. 280 (32): 28912–6. 2005. doi:10.1074/jbc.C500217200. PMID 15983050.
- "BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.". J. Biol. Chem. 280 (35): 30768–72. 2005. doi:10.1074/jbc.C500231200. PMID 16027166.
- "Genetic alterations of the BRI2 gene: familial British and Danish dementias.". Brain Pathol. 16 (1): 71–9. 2006. doi:10.1111/j.1750-3639.2006.tb00563.x. PMID 16612984.
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