Biology:Ependymin
| Ependymin Related 1 | |
|---|---|
 | |
| Identifiers | |
| Symbol | EPDR1 |
| Alt. symbols | EPDR, MERP1, UCC1 |
| Alt. names | Mammalian Ependymin-Related Protein 1, Upregulated In Colorectal Cancer Gene 1 Protein |
| NCBI gene | 54749 |
| HGNC | 17572 |
| OMIM | 619734 |
| RefSeq | NM_017549.5 |
| UniProt | Q9UM22 |
| Other data | |
| Locus | Chr. 7 p14.1 |
| Wikidata | Q18041226 |
Ependymin is a glycoprotein found in the cerebrospinal fluid of many teleost fish. The humans homolog is called ependymin related 1 that is encoded by the EPDR1 gene.
Ependymin is associated with the consolidation of long-term memory, possibly providing protection from strokes, and contributing to neuronal regeneration.[1] This encoded protein was originally detected in elevated amounts of fluid within the central nervous system of teleost fishes.[2] Along with long-term memory and neuronal regeneration, ependymin has been connected to specific aspects of changes in signaling within nerve cells leading to brain plasticity,[3] as well as behavioral performance in response to environment stress in fishes.[4] For example, this glycoprotein interaction in the extracellular matrix influences cell adhesion and migration processes in the central nervous system of teleost fishes.[5] The presence of ependymin-related proteins can be found in both vertebrates and invertebrates.[6] They have variety of functional roles in non-neural sites of organisms.[6] For example, an ependymin-related gene that is upregulated in colon cancer known as UCC1 was found in human colorectal tumor cells.[7]
References
- ↑ "Molecular evolution of the ependymin protein family: a necessary update". BMC Evolutionary Biology 7: 23. February 2007. doi:10.1186/1471-2148-7-23. PMID 17302986.
- ↑ "Ependymin, a brain extracellular glycoprotein, and CNS plasticity". Annals of the New York Academy of Sciences 627 (1 Activity–Driv): 94–114. August 1991. doi:10.1111/j.1749-6632.1991.tb25916.x. PMID 1831964. Bibcode: 1991NYASA.627...94S.
- ↑ "Involvement of L1.1 in memory consolidation after active avoidance conditioning in zebrafish". Journal of Neurobiology 43 (4): 389–403. June 2000. doi:10.1002/1097-4695(20000615)43:4<389::aid-neu7>3.3.co;2-o. PMID 10861564.
- ↑ "Cold-induced ependymin expression in zebrafish and carp brain: implications for cold acclimation". FEBS Letters 459 (1): 95–99. October 1999. doi:10.1016/s0014-5793(99)01229-6. PMID 10508924.
- ↑ "Ependymins: New Data on Participation in the Regulation of Physiological and Behavioral Responses in Teleosts (Review)" (in en). Inland Water Biology 14 (1): 78–86. 2021-01-01. doi:10.1134/S199508292101003X. ISSN 1995-0837.
- ↑ 6.0 6.1 "The evolution of ependymin-related proteins". BMC Evolutionary Biology 18 (1): 182. December 2018. doi:10.1186/s12862-018-1306-y. PMID 30514200.
- ↑ "The novel ependymin related gene UCC1 is highly expressed in colorectal tumor cells". Cancer Letters 165 (1): 71–79. April 2001. doi:10.1016/S0304-3835(01)00390-1. PMID 11248421.
External links
- "Ependymin-dervied Drugs: Behind CereMedix's Absurd Claims". biologicalgerontology.com. http://www.circuitblue.com/biogerontology/ependymin.html.
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