Biology:RPL22L1
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Ribosomal protein L22 like 1 (RPL22L1), or eL22L1, is a protein that in humans is encoded by the RPL22L1 gene. [1]
Function
eL22L1 is a ribosomal protein paralog of the eL22 protein of the 60S ribosomal subunit. This paralog is divergent from the normal copy, and is expressed when the normal copy is deleted from mice.[2] This compensation implies a ribosome function similar to the normal copy, though eL22L1 has also been implicates in other extraribosomal roles including pre-mRNA splicing regulation in zebrafish.[3]
See also
- RPL22
- 60S ribosomal subunit
References
- ↑ "Entrez Gene: Ribosomal protein L22 like 1". http://www.ncbi.nlm.nih.gov/gene/200916.
- ↑ Copenhaver, Gregory P., ed (2013-08-22). "The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1". PLOS Genetics (Public Library of Science (PLoS)) 9 (8): e1003708. doi:10.1371/journal.pgen.1003708. PMID 23990801.
- ↑ "Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing". Cell Reports (Elsevier BV) 18 (2): 545–556. January 2017. doi:10.1016/j.celrep.2016.12.034. PMID 28076796.
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